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Sex Differences in Neurophysiological Activation Patterns During Phonological Input Processing: An Influencing Factor for Normative Data

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Abstract

In the context of neurophysiological normative data, it has been established that aging has a significant impact on neurophysiological correlates of auditory phonological input processes, such as phoneme discrimination (PD) and word recognition (WR). Besides age, sex is another demographic factor that influences several language processes. We aimed to disentangle whether sex has a similar effect on PD and WR. Event-related potentials (ERPs) were recorded in 20 men and 24 women. During PD, three phonemic contrasts (place and manner of articulation and voicing) were compared using the attentive P300 and pre-attentive Mismatch Negativity. To investigate WR, real words were contrasted with pseudowords in a pre-attentive oddball task. Women demonstrated a larger sensitivity to spectrotemporal differences, as evidenced by larger P300 responses to the place of articulation (PoA) contrast and larger P300 and MMN responses than men in PoA-based PD. Men did not display such sensitivity. Attention played an important role, considering that women needed more attentional resources to differentiate between PoA and the other phonemic contrasts. During WR, pseudowords evoked larger amplitudes already 100 ms post-stimulus independent of sex. However, women had decreased P200 latencies, but longer N400 latencies in response to pseudowords, whereas men showed increased N400 latencies compared to women in response to real words. The current results demonstrate significant sex-related influences on phonological input processes. Therefore, existing neurophysiological normative data for age should be complemented for the factor sex.

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References

  • Aerts, A., van Mierlo, P., Hartsuiker, R. J., Hallez, H., Santens, P., & De Letter, M. (2013). Neurophysiological investigation of phonological input: Aging effects and development of normative data. Brain and Language, 125, 253–263.

    Article  PubMed  Google Scholar 

  • Allendorfer, J. B., Lindsell, C. J., Siegel, M., Banks, C. L., Vannest, J., Holland, S. K., & Szaflarski, J. P. (2012). Females and males are highly similar in language performance and cortical activation patterns during verb generation. Cortex, 48, 1218–1233.

    Article  PubMed Central  PubMed  Google Scholar 

  • Attias, J., & Pratt, H. (1992). Auditory event related potentials during lexical categorization in the oddball paradigm. Brain and Language, 43, 230–239.

    Article  PubMed  Google Scholar 

  • Basso, A. (2003). Aphasia and its therapy. New York: Oxford University Press.

    Google Scholar 

  • Baxter, L. C., Saykin, A. J., Flashman, L. A., Johnson, S. C., Guerin, S. J., Babcock, D. R., & Wishart, H. A. (2003). Sex differences in semantic language processing: A functional MRI study. Brain and Language, 84, 264–272.

    Article  PubMed  Google Scholar 

  • Bormann, T., & Weiller, C. (2012). “Are there lexicons?” A study of lexical and semantic processing in word-meaning deafness suggests “yes”. Cortex, 48, 294–307.

    Article  PubMed  Google Scholar 

  • Brumback, T., Arbel, Y., Donchin, E., & Goldman, M. S. (2012). Efficiency of responding to unexpected information varies with sex, age, and pubertal development in early adolescence. Psychophysiology, 49, 1330–1339.

    Article  PubMed Central  PubMed  Google Scholar 

  • Charlton, B. D., Taylor, A. M., & Reby, D. (2013). Are men better than women at acoustic size judgements? Biology Letters,. doi:10.1098/rsbl.2013.0270.

    PubMed Central  PubMed  Google Scholar 

  • Chétail, F., Colin, C., & Content, A. (2012). Electrophysiological markers of syllable frequency during written word recognition in French. Neuropsychologia, 50, 3429–3439.

    Article  PubMed  Google Scholar 

  • Coltheart, M. (2004). Are there lexicons? Quarterly Journal of Experimental Psychology, 57, 1153–1171.

    Article  PubMed  Google Scholar 

  • Cooper, R. J., Todd, J., McGill, K., & Michie, P. (2006). Auditory sensory memory and the aging brain: A mismatch negativity study. Neurobiology of Aging, 27, 752–762.

    Article  PubMed  Google Scholar 

  • Dalebout, S. D., & Stack, J. W. (1999). Mismatch negativity to acoustic differences not differentiated behaviorally. Journal of the American Academy of Audiology, 10, 388–399.

    PubMed  Google Scholar 

  • Daltrozzo, J., Wioland, N., & Kotchoubey, B. (2007). Sex differences in two event-related potentials components related to semantic priming. Archives of Sexual Behavior, 36, 555–568.

    Article  PubMed  Google Scholar 

  • Desroches, A. S., Newman, R. L., & Joanisse, M. F. (2008). Investigating the time course of spoken word recognition: Electrophysiological evidence for the influences of phonological similarity. Journal of Cognitive Neuroscience, 21, 1893–1906.

    Article  Google Scholar 

  • Diesch, E., & Luce, T. (1997). Magnetic mismatch fields elicited by vowels and consonants. Experimental Brain Research, 116, 139–152.

    Article  PubMed  Google Scholar 

  • Digeser, F. M., Wohlberedt, T., & Hoppe, U. (2009). Contribution of spectrotemporal features on auditory event-related potentials elicited by consonant-vowel syllables. Ear and Hearing, 30, 704–712.

    Article  PubMed  Google Scholar 

  • Duncan, C. C., Barry, R. J., Connolly, J. F., Fischer, C., Michie, P. T., Näätänen, R., … Van Petten, C. (2009). Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clinical Neurophysiology, 120, 1883–1908.

  • Ellis, A. W., & Young, A. W. (1996). Human cognitive neuropsychology: A textbook with readings (2nd ed.). Hove: Psychology Press.

    Google Scholar 

  • Friedrich, C. K., Eulitz, C., & Lahiri, A. (2006). Not every pseudoword disrupts word recognition: An ERP study. Behavioral and Brain Functions,. doi:10.1186/1744-9081-2-36.

    PubMed Central  PubMed  Google Scholar 

  • Frost, J. A., Binder, J. R., Springer, J. A., Hammeke, T. A., Bellgowan, P. S. F., Rao, S. M., & Cox, R. W. (1999). Language processing is strongly left lateralized in both sexes. Evidence from functional MRI. Brain, 122, 199–208.

    Article  PubMed  Google Scholar 

  • Garagnani, M., Wennekers, T., & Pulvermüller, F. (2008). A neuroanatomically grounded Hebbian-learning model of attention–language interactions in the human brain. European Journal of Neuroscience, 27, 492–513.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ghyselinck, M., Custers, R., & Brysbaert, M. (2003). Age-of-acquisition ratings for 2332 Dutch words from 49 different semantic categories. Psychologica Belgica, 43, 181–214.

    Google Scholar 

  • Giaquinto, S., Ranghi, F., & Butler, S. (2007). Stability of word comprehension with age: An electrophysiological study. Mechanisms of Aging and Development, 128, 628–636.

    Article  Google Scholar 

  • Gölgeli, A., Süer, C., Özesmi, Ç., Dolu, N., Ascioglu, M., & Sahin, Ö. (1999). The effect of sex differences on event-related potentials in young adults. International Journal of Neuroscience, 99, 69–77.

    Article  PubMed  Google Scholar 

  • Gur, R. C., Turetsky, B. I., Matsui, M., Yan, M., Bilker, W., Hughett, P., & Gur, R. E. (1999). Sex differences in brain gray and white matter in healthy young adults: Correlations with cognitive performance. Journal of Neuroscience, 19, 4065–4072.

    PubMed  Google Scholar 

  • Harasty, J., Double, K. L., Halliday, G. M., Kril, J. J., & McRitchie, D. A. (1997). Language-associated cortical regions are proportionally larger in the female brain. Archives of Neurology, 54, 171–176.

    Article  PubMed  Google Scholar 

  • Hauk, O., Davis, M. H., Ford, M., Pulvermüller, F., & Marslen-Wilson, W. D. (2006). The time course of visual word recognition as revealed by linear regression analysis of ERP data. NeuroImage, 30, 1383–1400.

    Article  PubMed  Google Scholar 

  • Hauk, O., & Pulvermüller, F. (2004). Effects of word length and frequency on the human event-related potential. Clinical Neurophysiology, 115, 1090–1103.

    Article  PubMed  Google Scholar 

  • Hessler, D., Jonkers, R., Stowe, L., & Bastiaanse, R. (2013). The whole is more than the sum of its parts: Audiovisual processing of phonemes investigated with ERPs. Brain and Language, 124, 213–224.

    Article  PubMed  Google Scholar 

  • Hickok, G., & Poeppel, D. (2004). Dorsal and ventral streams: A framework for understanding aspects of the functional anatomy of language. Cognition, 92, 67–99.

    Article  PubMed  Google Scholar 

  • Horev, N., Most, T., & Pratt, H. (2007). Categorical perception of speech (VOT) and analogous non-speech (FOT) signals: Behavioral and electrophysiological correlates. Ear and Hearing, 28, 111–128.

    Article  PubMed  Google Scholar 

  • Ikezawa, S., Nakagome, K., Mimura, M., Shinoda, J., Itoh, K., Homma, I., & Kamijima, K. (2008). Gender differences in lateralization of mismatch negativity in dichotic listening tasks. International Journal of Psychophysiology, 68, 41–50.

    Article  PubMed  Google Scholar 

  • Jausovec, N., & Jausovec, K. (2009). Gender related differences in visual and auditory processing of verbal and figural tasks. Brain Research, 1300, 135–145.

    Article  PubMed  Google Scholar 

  • Johnson, R. (1986). A triarchic model of P300 amplitude. Psychophysiology, 23, 367–384.

    Article  PubMed  Google Scholar 

  • Kansaku, K., Yamaura, A., & Kitazawa, S. (2000). Sex differences in lateralization revealed in the posterior language areas. Cerebral Cortex, 10, 866–872.

    Article  PubMed  Google Scholar 

  • Kasai, K., Nakagome, K., Iwanami, A., Fukuda, M., Itoh, K., Koshida, I., & Kato, N. (2002). No effect of gender on tonal and phonetic mismatch negativity in normal adults assessed by a high-resolution EEG recording. Cognitive Brain Research, 13, 305–312.

    Article  PubMed  Google Scholar 

  • Kaukoranta, E., Hari, R., & Lounasmaa, O. V. (1987). Responses of the human auditory cortex to vowel onset after fricative consonants. Experimental Brain Research, 69, 19–23.

    Article  PubMed  Google Scholar 

  • Keuleers, E., Brysbaert, M., & New, B. (2010). SUBTLEX-NL: A new frequency measure for Dutch words based on film subtitles. Behavior Research Methods, 42, 643–650.

    Article  PubMed  Google Scholar 

  • Korczak, P. A., & Stapells, D. R. (2010). Effects of various articulatory features of speech on cortical event-related potentials and behavioral measures of speech-sound processing. Ear and Hearing, 31, 491–504.

    Article  PubMed  Google Scholar 

  • Kutas, M., & Federmeier, K. D. (2000). Electrophysiology reveals semantic memory use in language comprehension. Trends in Cognitive Sciences, 4, 463–470.

    Article  PubMed  Google Scholar 

  • Kutas, M., & Federmeier, K. D. (2011). Thirty years and counting: Finding meaning in the N400 component of the event-related brain potential (ERP). Annual Review of Psychology, 62, 621–647.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kutas, M., & Hillyard, S. A. (1980). Reading senseless sentences: Brain potentials reflect semantic incongruity. Science, 207, 203–205.

    Article  PubMed  Google Scholar 

  • Laszlo, S., Stites, M., & Federmeier, K. D. (2012). Won’t get fooled again: An event-related potential study of task and repetition effects on the semantic processing of items without semantics. Language and Cognitive Processes, 27, 257–274.

    Article  PubMed Central  PubMed  Google Scholar 

  • Liederman, J., Gilbert, K., McGraw-Fisher, J., Mathews, G., Frye, R. E., & Joshi, P. (2010). Are women more influenced than men by top-down semantic information when listening to disrupted speech? Language and Speech, 54, 33–48.

    Article  Google Scholar 

  • Liederman, J., McGraw-Fisher, J., Coty, A., Matthews, G., Frye, R. E., Lincoln, A., & Alexander, R. (2013). Sex differences in the use of delayed semantic context when listening to disrupted speech. Archives of Sexual Behavior, 42, 197–201.

    Article  PubMed  Google Scholar 

  • Linden, D. E. J. (2005). The P300: Where in the brain is it produced and what does it tell us? The Neuroscientist, 11, 563–576.

    Article  PubMed  Google Scholar 

  • Maiste, A. C., Wiens, A. S., Hunt, M. J., Scherg, M., & Picton, T. W. (1995). Event-related potentials and the categorical perception of speech sounds. Ear and Hearing, 16, 68–90.

    Article  PubMed  Google Scholar 

  • Majeres, R. L. (1999). Sex differences in phonological processes: Speeded matching and word reading. Memory and Cognition, 27, 246–253.

    Article  PubMed  Google Scholar 

  • Marsi, E., Busser, B., Daelemans, W., Hoste, V., Reynaert, M., & van den Bosch, A. (2002). In Combining information sources for memory-based pitch accent placement. Paper presented at the International Conference on Spoken Language Processing, Denver Co.

  • Martin-Loeches, M., Hinojosa, J. A., Gomez-Jarabo, G., & Rubia, F. J. (1999). The recognition potential: An ERP index of lexical access. Brain and Language, 70, 364–384.

    Article  PubMed  Google Scholar 

  • Matsubayashi, J., Kawakubo, Y., Suga, M., Takei, Y., Kumano, S., Fukuda, M., … Kasai, K. (2008). The influence of gender and personality traits on individual difference in auditory mismatch: A magnetoencephalographic (MMNm) study. Brain Research, 1236, 159–165.

  • Näätänen, R., Gaillard, A. W., & Mäntysalo, S. (1978). Early selective-attention effect on evoked potential reinterpreted. Acta Psychologica, 42, 313–329.

    Article  PubMed  Google Scholar 

  • Näätänen, R., Kujala, T., & Winkler, I. (2011). Auditory processing that leads to conscious perception: A unique window to central auditory processing opened by the mismatch negativity and related responses. Psychophysiology, 48, 4–22.

    Article  PubMed  Google Scholar 

  • Näätänen, R., Paavilainen, P., Rinne, T., & Alho, K. (2007). The mismatch negativity (MMN) in basic research of central auditory processing: A review. Clinical Neurophysiology, 118, 2544–2590.

    Article  PubMed  Google Scholar 

  • Nagy, E., Potts, G. F., & Loveland, K. A. (2003). Sex-related ERP differences in deviance detection. International Journal of Psychophysiology, 48, 285–292.

    Article  PubMed  Google Scholar 

  • Obleser, J., Eulitz, C., Lahiri, A., & Elbert, T. (2001). Gender differences in functional hemispheric asymmetry during processing of vowels as reflected by the human brain magnetic response. Neuroscience Letters, 314, 131–134.

    Article  PubMed  Google Scholar 

  • Obleser, J., Lahiri, A., & Eulitz, C. (2003). Auditory-evoked magnetic field codes place of articulation in timing and topography around 100 milliseconds post syllable onset. NeuroImage, 20, 1839–1847.

    Article  PubMed  Google Scholar 

  • Obleser, J., Lahiri, A., & Eulitz, C. (2004). Magnetic brain response mirrors extraction of phonological features from spoken vowels. Journal of Cognitive Neuroscience, 16, 31–39.

    Article  PubMed  Google Scholar 

  • Ostroff, J. M., Martin, B. A., & Boothroyd, A. (1998). Cortical evoked response to acoustic change within a syllable. Ear and Hearing, 19, 290–297.

    Article  PubMed  Google Scholar 

  • Peers, P. V., Ludwig, C. J., Rorden, C., Cusack, R., Bonfiglioli, C., Bundesen, C., … Duncan, J., (2005). Attentional functions of parietal and frontal cortex. Cerebral Cortex, 15, 1469–1484.

  • Polich, J. (2004). Clinical application of the P300 event-related brain potential. Physical Medicine and Rehabilitation Clinics of North America, 15, 133–161.

    Article  PubMed  Google Scholar 

  • Proverbio, A. M., & Adorni, R. (2008). Orthographic familiarity, phonological legality and number of orthographic neighbours affect the onset of ERP lexical effects. Behavioral and Brain Functions. doi:10.1186/1744-9081-4-27.

    PubMed Central  PubMed  Google Scholar 

  • Pylkkänen, L., Stringfellow, A., & Marantz, A. (2002). Neuromagnetic evidence for the timing of lexical activation: An MEG component sensitive to phonotactic probability but not to neighborhood density. Brain and Language, 81, 666–678.

    Article  PubMed  Google Scholar 

  • Rietveld, A. C. M., & van Heuven, V. J. (2009). Algemene fonetiek (3rd ed.). Bussum: Coutinho.

    Google Scholar 

  • Sharma, A., & Dorman, M. F. (1999). Cortical auditory evoked potential correlates of categorical perception of voice-onset time. Journal of the Acoustical Society of America, 106, 1078–1083.

    Article  PubMed  Google Scholar 

  • Sharma, A., & Dorman, M. F. (2000). Neurophysiologic correlates of cross-language phonetic perception. Journal of the Acoustical Society of America, 107, 2697–2703.

    Article  PubMed  Google Scholar 

  • Shaywitz, B. A., Shaywitz, S. E., Pugh, K. R., Constable, R. T., Skudlarski, P., Fulbright, R. K., … Gore, J. C. (1995). Sex differences in the functional organization of the brain for language. Nature, 373, 607–609.

  • Sinai, A., & Pratt, H. (2002). Electrophysiological evidence for priming in response to words and pseudowords in first and second language. Brain and Language, 80, 240–252.

    Article  PubMed  Google Scholar 

  • Soares, I., Collet, L., & Duclaux, R. (1991). Electrophysiological correlates of auditory lexical decision: An attempt to test the “cohort model”. International Journal of Neuroscience, 57, 111–122.

    Article  PubMed  Google Scholar 

  • Sommer, I. E. C., Aleman, A., Bouma, A., & Kahn, R. S. (2004). Do women really have more bilateral language representation than men? A meta-analysis of functional imaging studies. Brain, 127, 1845–1852.

    Article  PubMed  Google Scholar 

  • Sowell, E. R., Peterson, B. S., Kan, E., Woods, R. P., Yoshii, J., Bansal, R., … Toga, A. W. (2007). Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age. Cerebral Cortex, 17, 1550–1560.

  • Spironelli, C., Angrilli, A., & Pertile, M. (2008). Language plasticity in aphasics after recovery: Evidence from slow evoked potentials. NeuroImage, 40, 912–922.

    Article  PubMed  Google Scholar 

  • Sutton, S., Braren, M., Zubin, J., & John, E. R. (1965). Evoked-potential correlates of stimulus uncertainty. Science, 150, 1187–1188.

    Article  PubMed  Google Scholar 

  • Swink, S., & Stuart, A. (2012). The effect of gender on the N1–P2 auditory complex while listening and speaking with altered auditory feedback. Brain and Language, 122, 25–33.

    Article  PubMed  Google Scholar 

  • Tampas, J. W., Harkrider, A. W., & Hedrick, M. S. (2005). Neurophysiological indices of speech and nonspeech stimulus processing. Journal of Speech, Language and Hearing Research, 48, 1147–1164.

    Article  Google Scholar 

  • Taroyan, N. A., & Nicolson, R. I. (2009). Reading words and pseudowords in dyslexia: ERP and behavioural tests in English-speaking adolescents. International Journal of Psychophysiology, 74, 199–208.

    Article  PubMed  Google Scholar 

  • Tavabi, K., Obleser, J., Dobel, C., & Pantev, C. (2007). Auditory evoked fields differentially encode speech features: An MEG investigation of the P50m and N100m time courses during syllable processing. European Journal of Neuroscience, 25, 3155–3162.

    Article  PubMed  Google Scholar 

  • Tressoldi, P. E., & Cusumano, S. (1992). Visual evoked potentials related to behavioral asymmetries during foveal attention in the two extrapersonal hemispaces. Brain and Cognition, 18, 125–137.

    Article  PubMed  Google Scholar 

  • Van Strien, J. W. (1992). Classificatie van links- en rechtshandige proefpersonen. Nederlands Tijdschrift voor de Psychologie en Haar Grensgebieden, 47, 88–92.

    Google Scholar 

  • Volpe, U., Mucci, A., Bucci, P., Merlotti, E., Galderisi, S., & Maj, M. (2007). The cortical generators of P3a and P3b: A LORETA study. Brain Research Bulletin, 73, 220–230.

    Article  PubMed  Google Scholar 

  • Wang, L., Bastiaansen, M., Yanga, Y., & Hagoort, P. (2011). The influence of information structure on the depth of semantic processing: How focus and pitch accent determine the size of the N400 effect. Neuropsychologia, 49, 813–820.

    Article  PubMed  Google Scholar 

  • Wegesin, D. J. (1998). Event-related potentials in homosexual and heterosexual men and women: Sex-dimorphic patterns in verbal asymmetries and mental rotation. Brain and Cognition, 36, 73–92.

    Article  PubMed  Google Scholar 

  • Weiss, E. M., Kemmler, G., Deisenhammer, E. A., Fleischhacker, W. W., & Delazer, M. (2003). Sex differences in cognitive functions. Personality and Individual Differences, 35, 863–875.

    Article  Google Scholar 

  • Wirth, M., Horn, H., Koenig, T., Stein, M., Federspiel, A., Meier, B., … Strik, W. (2007). Sex differences in semantic processing: Event-related brain potentials distinguish between lower and higher order semantic analysis during word reading. Cerebral Cortex, 17, 1987–1997.

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Acknowledgments

This project has been financed with the aid of an Aspirant Fellowship granted to the first author by the Fund for Scientific Research–Flanders.

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Authors and Affiliations

  1. Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185 (1K12-IA), 9000, Ghent, Belgium

    Annelies Aerts & Patrick Santens

  2. Department of Neurology, Ghent University Hospital, Ghent, Belgium

    Annelies Aerts, Patrick Santens & Miet De Letter

  3. Department of Electronics and Information Systems, Medical Image and Signal Processing Group, Ghent University, Ghent, Belgium

    Pieter van Mierlo

  4. Department of Experimental Psychology, Ghent University, Ghent, Belgium

    Robert J. Hartsuiker

  5. Department of Speech, Language and Hearing Sciences, Ghent University, Ghent, Belgium

    Miet De Letter

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  1. Annelies Aerts
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Aerts, A., van Mierlo, P., Hartsuiker, R.J. et al. Sex Differences in Neurophysiological Activation Patterns During Phonological Input Processing: An Influencing Factor for Normative Data. Arch Sex Behav 44, 2207–2218 (2015). https://doi.org/10.1007/s10508-015-0560-y

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