Abstract
The roots of Asparagus racemosus, Chlorophytum borivilianum, and rhizomes of Curculigo orchioides are popular for their aphrodisiac and immunostimulatory properties. The herbs have been traditionally used as Vajikaran Rasayana herbs because of their putative positive influence on sexual performance in humans. Lyophilized aqueous extracts obtained from the roots of A. racemosus, C. borivilianum, and rhizomes of C. orchioides were studied for sexual behavior effects in male albino rats and compared with untreated control group animals (total N = 60). The rats were evaluated for effect of treatments on anabolic effect. Seven measures of sexual behavior were evaluated. Administration of 200 mg/kg body weight of the aqueous extracts had pronounced anabolic effect in treated animals as evidenced by weight gains in the body and reproductive organs. There was a significant variation in the sexual behavior of animals as reflected by reduction of mount latency, ejaculation latency, post ejaculatory latency, intromission latency, and an increase of mount frequency. Penile erection (indicated by Penile Erection Index) was also considerably enhanced. Reduced hesitation time (an indicator of attraction towards female in treated rats) also indicated an improvement in sexual behavior of extract treated animals. The observed effects appear to be attributable to the testosterone-like effects of the extracts. Nitric oxide based intervention may also be involved as observable from the improved penile erection. The present results, therefore, support the folklore claim for the usefulness of these herbs and provide a scientific basis for their purported traditional usage.
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References
Agmo, A. (1997). Male rat sexual behavior. Brain Research Protocol, 1, 203–209.
Agmo, A. (2003). Unconditioned sexual incentive motivation in the male Norway rat (Rattus norvegicus). Journal of Comparative Psychology, 117, 3–14.
Ang, H. H., & Ngai, T. H. (2001). Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack. Fundamental & Clinical Pharmacology, 15, 265–268.
Ang, H. H., Ngai, T. H., & Tan, T. H. (2003). Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine, 10, 590–593.
Anonymous. (2000). The wealth of India: Raw materials (Vol. 1 A-Ci, pp. 200–210). New Delhi: National Institute of Sciences Communication.
Arver, S., Dobs, A. S., Meikle, A. W., Allen, R. P., Sander, S. W., & Mazer, N. A. (1996). Improvement of sexual function in testosterone deficient men treated for 1 year with permeability enhanced testosterone transdermal system. Journal of Urology, 155, 1604–1608.
Benassi-Benelli, A., Ferrari, F., & Pellegrini-Quarantotti, B. (1979). Penile erection induced by apomorphine and N-n-apopolymorphine in rats. Archives International de Pharmacodynamie et de Therapie, 242, 241–247.
Chauhan, N. S., Rao, C. V., & Dixit, V. K. (2007). Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats. Fitoterapia, 78, 530–534.
Damassa, D. A., Smith, E. R., Tennent, B. J., & Davidson, J. M. (1977). The relationship between circulating testosterone levels and sexual behavior. Hormones and Behavior, 8, 275–286.
Ferguson, H., Hemnriksen, S., Cohen, H., Mitchell, G., Barcha, J., & Dement, W. (1970). Hypersexuality and behavioral changes caused in cats by administration of p-Chlorophenylalanine. Science, 168, 499–501.
Gray, J. M., Nunez, A. A., Siegel, L. L., & Wade, G. N. (1979). Effects of testosterone on body weight and adipose tissue: Role of aromatization. Physiology & Behavior, 23, 465–469.
Gilna, S. (2004). Testosterone and erectile dysfunction. Journal of Medical Health of Gonads, 1, 407–412.
Govindarajan, R., Srividya, N., Vijaykumar, M., Thakur, M., Dixit, V. K., Mehrotra, S., et al. (2005). In vitro antioxidant activity of Chlorophytum borivilianum. Natural Product Sciences, 11, 165–169.
Haren, M. T., Morley, J. E., Chapman, I. M., O’ Loughlin, P. D., & Wittert, G. A. (2002). Defining relative androgen deficiency in aging men: How should testosterone be measured and what are the relationships between androgen levels and physical, sexual and emotional health. Climacteric, 5, 15–25.
Islam, M. W., Tariq, M., Ageel, A. M., Al-Said, M. S., & Al-Yhya, A. M. (1991). Effect of Salvia hematodes on sexual behavior of male rats. Journal of Ethnopharmacology, 33, 67–72.
Kirtikar, K. R., & Basu, B. D. (1984). Indian medicinal plants (Vol. 2, pp. 2469–2470). Calcutta: Prabhasi Prakashan.
Luo, Q., Li, Z., Huang, X., Yan, J., Zhang, S., & Cai, Y. Z. (2006). Lycium barbarum polysaccharides: Protective effect against heat induced damage of rat testis and H2O2 induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sciences, 79, 613–621.
Ottoni, E. B. (2000). EthoLog 2.2—a tool for the transcription and timing of behavior observation sessions. Behavior Research Methods, Instruments, & Computers, 32, 1–7.
Palmer, E. (1999). Making the love drug. Chemistry in Britain, 35, 24–26.
Saxena, S., & Dixit, V. K. (1987). Role of total alkaloids of Mucuna pruriens baker in spermatogenesis in male rats. Indian Journal of Natural Products, 3, 3–7.
Shrikumar, S., Athem, M., Sukumar, M., & Ravi, T. K. (2005). A HPTLC method for standardization of Curculigo orchioides rhizomes and its marketed formulation using gallic acid as standard. Indian Journal of Pharmaceutical Sciences, 67, 721–724.
Shukla, N., Jones, R., Persad, R., Angelini, G. G., & Jeremy, J. Y. (2005). Effect of sildenafil citrate an nitric oxide donating sildenafil derivative NCX 911 on cavernosal relaxation and superoxide formation in hypercholestrolaemic rabbits. European Journal of Pharmacology, 517, 224–231.
Smith, G. E. (1974). Papyrus Ebers. Chicago: Ares Publishers.
Thakur, M., Bhargava, S., & Dixit, V. K. (2007). Immunomodulatory activity of Chlorophytum borivilianum Sant F. Evidence Based Complimentary and Alternative Medicine, 4, 419–423.
Thakur, M., & Dixit, V. K. (2006). Effect of Chlorophytum borivilianum on androgenic and sexual behavior of male rats. Indian Drugs, 43, 300–306.
Thakur, M., & Dixit, V. K. (2007). Effect of some vajikarana herbs on pendiculation activities and in-vitro sperm count in male. Sexuality and Disability, 25, 203–207.
Thakur, M., & Dixit, V. K. (2008). Ameliorative effect of fructo-oligosaccharide rich extract of Orchis latifolia Linn on sexual dysfunction in hyperglycemic male rats. Sexuality and Disability, 26, 37–46.
Triveni, A. (1977). Rasendrasarasangrah: Vajikaranadhikar. Rajkot, India: Nutan Press.
Acknowledgments
The authors are thankful to Nandan Agro Farms (Pvt. Ltd.) Hyderabad, A.P. India for providing gift sample of Chlorophytum borivilianum. We would also like to thank University Grants Commission for funding as major research project. The first author would like to acknowledge Professor Werner Praznik and Dr. Renate Loeppert for their support in phytochemical analysis and OEAD, Austria for North South Dialogue Scholarship.
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Thakur, M., Chauhan, N.S., Bhargava, S. et al. A Comparative Study on Aphrodisiac Activity of Some Ayurvedic Herbs in Male Albino Rats. Arch Sex Behav 38, 1009–1015 (2009). https://doi.org/10.1007/s10508-008-9444-8
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DOI: https://doi.org/10.1007/s10508-008-9444-8
Keywords
- Asparagus racemosus
- Chlorophytum borivilianum
- Curculigo orchioides
- Sexual stimulant