Short- and Long-term Effects of Ginkgo Biloba Extract on Sexual Dysfunction in Women
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Ginkgo biloba extract (GBE) facilitates blood flow, influences nitric oxide systems, and has a relaxant effect on smooth muscle tissue. These processes are important to the sexual response in women and, hence, it is feasible that GBE may have a therapeutic effect. The present study was the first to provide an empirical examination of the effects of both short- and long-term GBE administration on subjective and physiological (vaginal photoplethysmography) measures of sexual function in women with Sexual Arousal Disorder. A single dose of 300 mg GBE had a small but significant facilitatory effect on physiological, but not subjective, sexual arousal compared to placebo in 99 sexually dysfunctional women. The long-term effects of GBE on sexual function were assessed in 68 sexually dysfunctional women who were randomly assigned to 8 weeks treatment of either (1) GBE (300 mg/daily), (2) placebo, (3) sex therapy which focused on training women to attend to genital sensations, or (4) sex therapy plus GBE. When combined with sex therapy, but not alone, long-term GBE treatment significantly increased sexual desire and contentment beyond placebo. Sex therapy alone significantly enhanced orgasm function compared with placebo. Long-term GBE administration did not significantly enhance arousal responses beyond placebo. It was concluded that (1) neither short- or long-term administration of GBE alone substantially impacts sexual function in women, (2) a substantial placebo effect on sexual function exists in women with sexual concerns, and (3) teaching women to focus on genital sensations during sex enhances certain aspects of women’s sexual functioning.
KeywordsGinkgo biloba Female sexual dysfunction Sex therapy Vaginal photoplethysmography
This publication was made possible by Grant Number 5 RO1 AT00224-02 from the National Center for Complementary and Alternative Medicine to Cindy Meston. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Complementary and Alternative Medicine. The authors wish to thank Jessica Davis for her assistance in all phases of this investigation.
- Basson, R., & Brotto, L. A. (2003). Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: A randomized controlled trial. British Journal of Obstetrics and Gynecology, 100, 1014–1024.Google Scholar
- Boolell, M., Allen, M. J., Ballard, S. A., Gepi-Attee, S., Muirhead, G. J., Naylor, A. M., et al. (1996). Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. International Journal of Impotence Research, 8, 47–52.PubMedGoogle Scholar
- Bryk, A. S., Raudenbush, S. W., & Congdon, R. T. (1996). Hierarchical linear and nonlinear modeling with the HLM/2L and HLM/3L programs (2nd ed.). Chicago: Scientific Software International Inc.Google Scholar
- Chivers, M. L., Seto, M. C., Lalumiere, M. L., Laan, E., & Grimbos, T. (2005, July). The agreement of genital and subjective measures of sexual arousal: A meta-analysis. Poster presentation to the annual meeting of the International Academy of Sex Research, Ottawa, Canada.Google Scholar
- Christen, Y., Courtois, Y., & Droy-Lefaix, M. T. (1995). Effects of ginkgo biloba extract (EGB 761) on aging and age-related disorders. Paris, France: Elsevier.Google Scholar
- DeFeudis, F. V. (1991). Ginkgo biloba extract (GBE 761): Pharmacological activities and clinical applications. Paris, France: Elsevier.Google Scholar
- Dinsmore, W. W., Hodges, M., Hargreaves, C., Osterloh, I. H., Smith, M. D., & Rosen, R. C. (1999). Sildenafil citrate (Viagra) in erectile dysfunction: Near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects. Urology, 53, 800–805. [Erratum in: Urology, 1999, 53, 1072].PubMedCrossRefGoogle Scholar
- FDA Guidance document. (2000). Guidance for industry: Female sexual dysfunction: Clinical development of drug products for treatment. http://www.fda.gov/cder/guidance/3312dft.htm.
- Foa, E. B., Hembree, E. A., Cahill, S. P., Rauch, S. A. M., Riggs, D. S., Feeny, N. C., et al. (2005). Randomized trial of prolonged exposure for posttraumatic stress disorder with and without cognitive restructuring: Outcome at academic and community clinics. Journal of Consulting and Clinical Psychology, 73, 953–964.PubMedCrossRefGoogle Scholar
- Janssen, E. (2001). Psychophysiological measurement of sexual arousal. In M. W. Wiederman & B. E. Whitley (Eds.), Handbook for conducting research on human sexuality (pp. 139–171). Mahwah, NJ: Erlbaum.Google Scholar
- Kirsch, I. (1997). Specifying nonspecifics: Psychological mechanisms of placebo effects. In A. Harrington (Ed.), The placebo effect: An interdisciplinary exploration (pp. 166–186). Cambridge, MA: Harvard University Press.Google Scholar
- Koltringer, P., Eber, O., Lind, P., Langsteger, W., & Wakonig, P. (1989). Mikrozirkulation und Viskoelastizitat des Vollblutes unter Ginkgo-biloba-extrakt. Eine plazebokontrollierte, randomisierte Doppelblind-Studie. Perfusion, 1, 28–30.Google Scholar
- Meston, C. M., Rellini, A. H., & McCall, K. M. (2005, October). The sensitivity of continuous laboratory measures of physiological and subjective sexual arousal for diagnosing women’s sexual dysfunction. Poster presentation to the annual meeting of the International Society for the Study of Women’s Sexual Health, Las Vegas, NV.Google Scholar
- Park, K., Goldstein, I., Andry, C., Siroky, M., Krane, R. J., & Azadzoi, K. (1997). Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. International Journal of Impotence Research, 9, 27–37.PubMedCrossRefGoogle Scholar
- Prause, N., & Janssen, E. (2005). Blood flow: Vaginal photoplethysmography. In I. Goldstein, C. M. Meston, S. R. Davis, & A. M. Traish (Eds.), Women’s sexual function and dysfunction: Study, diagnosis, and treatment (pp. 368–382). London: Taylor & Francis.Google Scholar
- Rosen, R., Lane, R., & Menza, M. (1999). Effects of SSRIs on sexual function: A critical review. Journal of Clinical Pharmacology, 19, 67–85.Google Scholar
- Tyler, V. E. (1993). Ginkgo. In V. E. Tyler (Ed.), The honest herbal (pp. 149–151). New York: Pharmaceutical Products Press.Google Scholar
- Wiegel, M., Scepkowski, L. A., & Barlow, D. H. (2006). Cognitive and affective processes in female sexual dysfunction. In I. Goldstein, C. M. Meston, S. R. Davis, & A. M. Traish (Eds.), Women’s sexual function and dysfunction: Study, diagnosis, and treatment (pp. 85–92). London: Taylor & Francis.Google Scholar