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Effect of brewer’s yeast on immune response of giant freshwater prawn, Macrobrachium rosenbergii, and its resistance to white muscle disease

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The present study was conducted to find the effect of dietary brewer’s yeast on growth, survival, immune response, and resistance to white muscle disease in giant freshwater prawn, Macrobrachium rosenbergii. The brewer’s yeast was supplemented at graded levels 0, 5, 10, and 20 g per kg diet, and the experiment was conducted for 75 days. After the feeding trials, growth, survival, immune parameters like prophenoloxidase activity, respiratory burst, and total hemocyte count were assessed. The growth, specific growth rate, and survival were not found significantly different among the treatment and control groups “prophenoloxidase activity and respiratory burst” were found significantly different (p < 0.05) among the treatment and control groups. The total hemocyte count was significantly different (p < 0.05) among control and treatment groups. Cumulative percent survival was higher in M rosenbergii fed 1 % brewer’s yeast-supplemented diet when they were challenged with white muscle disease virus (MrNV (Macrobrachium rosenbergii nodavirus) and XSV (extra small virus)). The present work revealed that the incorporation of brewer’s yeast in the diet is effective in enhancing immune response and controlling the white muscle disease in M rosenbergii.

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Specific growth rate


White muscle disease


Total hemocyte count


Macrobrachium rosenbergii nodavirus


Extra small virus


Completely randomized design


Nitroblue tetrazolium




Prophenoloxidase activating enzyme




Superoxide dismutase


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Correspondence to C. S. Tejpal.

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Parmar, P.V., Murthy, H.S., Tejpal, C.S. et al. Effect of brewer’s yeast on immune response of giant freshwater prawn, Macrobrachium rosenbergii, and its resistance to white muscle disease. Aquacult Int 20, 951–964 (2012).

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