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Fig. 4 | Apoptosis

Fig. 4

From: Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury

Fig. 4

Maleic acid disrupts mitochondrial crista formation. To investigate the effect of mitochondrial ultrastructure after MA treatment on renal tubular cells, a transelectron microscope was used. A In MA-treated HK-2 cells, swollen, homogenized, and whirled cristae were observed, corresponding to mitochondrial damage (green arrow), whereas the mitochondrial structure in the control groups was normal (yellow arrow). The dot graph summarizes the quantification of the total numerical density of mitochondria between the two groups. Mitochondrial size between the two groups of HK-2 cells. B At a higher scale, damaged mitochondria with disrupted and discontinuous outer membranes and deficient cristae were observed in MA-treated HK-2 cells (green arrow). The mitochondrial sizes were significantly decreased in MA-treated HK-2 cells (Color figure online)

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