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The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions

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Abstract

Amino acids (AAs) are crucial molecules for the synthesis of mammalian proteins as well as a source of energy and redox equilibrium maintenance. The development of tumors also requires AAs as nutrients. Increased AAs metabolism is frequently seen in tumor cells to produce enough biomass, energy, and reduction agents. However, increased AA demand may result in auxotrophy in some cancer cells, highlighting the vulnerabilities of cancers and exposing the AA metabolism as a potential target for cancer therapy. The dynamic balance of cell survival and death is required for cellular homeostasis, growth, and development. Malignant cells manage to avoid cell death through a range of mechanisms, such as developing an addiction to amino acids through metabolic adaptation. In order to offer some guidance for AA-targeted cancer therapy, we have outlined the function of AA metabolism in tumor progression, the modalities of cell death, and the regulation of AA metabolism on tumor cell death in this review.

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The Key Research and Development Program of Shaanxi, China (No. 2020SF-061 to LZ).

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Authors and Affiliations

  1. The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, 311300, Zhejiang, China

    Jin Wang, Dongsheng Huang & Qiuran Xu

  2. Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Hangzhou, 311300, Zhejiang, China

    Jin Wang, Dongsheng Huang & Qiuran Xu

  3. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, 710061, Shaanxi, China

    Jin Wang, Min Gao & Yilei Zhang

  4. School of Pharmacy, Xi’an Jiaotong University Health Science Center, Xi’an, 710061, Shaanxi, China

    Hongying Wang

  5. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710065, Shaanxi, China

    Kangsheng Tu

  6. Department of Geriatric Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710065, Shaanxi, China

    Lei Zhang

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  1. Jin Wang
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Contributions

JW conceived and wrote this manuscript. HW and MG drawn the figures in this manuscript. YZ revised the manuscript according to the reviewer’s comments. LZ provided funding support, KT and DH provided revised suggestions for this manuscript. QX, and KT supervised the manuscript. All authors listed in this manuscript have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

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Wang, J., Wang, H., Gao, M. et al. The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions. Apoptosis 28, 1304–1314 (2023). https://doi.org/10.1007/s10495-023-01875-9

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