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Targeting of cancer cell death mechanisms by resveratrol: a review

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Abstract

Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free radicals and induction of DNA damage. However, cancer cells can acquire some new properties to adapt to anti-cancer agents. An increase in the incidence of apoptosis, mitotic catastrophe, senescence, and necrosis is in favor of overcoming tumor resistance to therapy. Although an increase in the autophagy process may help the survival of cancer cells, some studies indicated that stimulation of autophagy cell death may be useful for cancer therapy. Using some low toxic agents to amplify cancer cell death is interesting for the eradication of clonogenic cancer cells. Resveratrol (a polyphenol agent) may affect various signaling pathways related to cell death. It can induce death signals and also downregulate the expression of anti-apoptotic genes. Resveratrol has also been shown to modulate autophagy and induce mitotic catastrophe and senescence in some cancer cells. This review focuses on the important targets and mechanisms for the modulation of cancer cell death by resveratrol.

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References

  1. Goradel NH, Mohajel N, Malekshahi ZV et al (2019) Oncolytic adenovirus: a tool for cancer therapy in combination with other therapeutic approaches. J Cell Physiol 234:8636–8646

    CAS  PubMed  Google Scholar 

  2. Haddadi Gh RA, Ma M-S, Hosseinzadeh M, Fardid R, Najafi M et al (2017) Hesperidin as radioprotector against radiation-induced lung damage in rat: a histopathological study. J Med Phys 42:25–32

    PubMed  PubMed Central  Google Scholar 

  3. Rezaeyan AFR, Haddadi Gh, Ma T, Hosseinzadeh M, Najafi M et al (2016) Evaluating radioprotective effect of hesperidin on acute radiation damage in the lung tissue of rats. J Biomed Phys Eng 6:165–174

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249

    PubMed  Google Scholar 

  5. O’flanagan CH, Smith LA, Mcdonell SB et al (2017) When less may be more: calorie restriction and response to cancer therapy. BMC Med 15:1–9

    Google Scholar 

  6. Azmoonfar R, Amini P, Yahyapour R et al (2020) Mitigation of radiation-induced pneumonitis and lung fibrosis using alpha-lipoic acid and resveratrol. Anti-inflamm Anti-allergy Agents Med Chem 19:149–157

    CAS  Google Scholar 

  7. Mortezaee K, Goradel NH, Amini P et al (2019) NADPH oxidase as a target for modulation of radiation response; implications to carcinogenesis and radiotherapy. Curr Mol Pharmacol 12:50–60

    CAS  PubMed  Google Scholar 

  8. Van Der Valk M, Van Etten B, Marijnen C et al (2020) Compliance, acute toxicity and postoperative complications of short-course radiotherapy followed by chemotherapy and surgery for high-risk rectal cancer. Results of the randomized RAPIDO-trial. Eur J Surg Oncol 46:e20

    Google Scholar 

  9. Ji K, Sun X, Liu Y et al (2018) Regulation of apoptosis and radiation sensitization in lung cancer cells via the Sirt1/NF-κB/Smac pathway. Cell Physiol Biochem 48:304–316

    CAS  PubMed  Google Scholar 

  10. Lhuillier C, Rudqvist N-P, Elemento O et al (2019) Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system. Genome Med 11:40

    PubMed  PubMed Central  Google Scholar 

  11. Schulz A, Meyer F, Dubrovska A et al (2019) Cancer stem cells and radioresistance: DNA repair and beyond. Cancers 11:862

    CAS  PubMed Central  Google Scholar 

  12. Ashrafizadeh M, Farhood B, Musa AE et al (2020) The interactions and communications in tumor resistance to radiotherapy: therapy perspectives. Int Immunopharmacol 87:106807

    CAS  PubMed  Google Scholar 

  13. Farhood B, Aliasgharzadeh A, Amini P et al (2019) Radiation-induced dual oxidase upregulation in rat heart tissues: protective effect of melatonin. Medicina (Kaunas, Lithuania) 55:317

    Google Scholar 

  14. Yahyapour R, Shabeeb D, Cheki M et al (2018) Radiation protection and mitigation by natural antioxidants and flavonoids: implications to radiotherapy and radiation disasters. Curr Mol Pharmacol 11:285–304

    CAS  PubMed  Google Scholar 

  15. Mortezaee K (2020) Immune escape: a critical hallmark in solid tumors. Life Sci 258:118110

    CAS  PubMed  Google Scholar 

  16. Najafi M, Mortezaee K, Majidpoor J (2019) Stromal reprogramming: a target for tumor therapy. Life Sci 239:117049

    CAS  PubMed  Google Scholar 

  17. Ashrafizadeh M, Farhood B, Musa AE et al (2020) Damage-associated molecular patterns in tumor radiotherapy. Int Immunopharmacol 86:106761

    CAS  PubMed  Google Scholar 

  18. Wu J, Lanier LL (2003) Natural killer cells and cancer. Adv Cancer Res 90:127–156

    CAS  PubMed  Google Scholar 

  19. Amini P, Ashrafizadeh M, Motevaseli E et al (2020) Mitigation of radiation-induced hematopoietic system injury by melatonin. Environ Toxicol 35:815–821

    CAS  PubMed  Google Scholar 

  20. Nodooshan SJ, Amini P, Ashrafizadeh M et al (2020) Suberosin attenuates the proliferation of MCF-7 breast cancer cells in combination with radiotherapy or hyperthermi. Curr Drug Res Rev. https://doi.org/10.2174/2589977512666201228104528

    Article  Google Scholar 

  21. Farhood B, Ashrafizadeh M, Hoseini-Ghahfarokhi M et al (2020) Targeting of cellular redox metabolism for mitigation of radiation injury. Life Sci 250:117570

    CAS  PubMed  Google Scholar 

  22. Ashrafizadeh M, Farhood B, Musa AE et al (2020) Abscopal effect in radioimmunotherapy. Int Immunopharmacol 85:106663

    CAS  PubMed  Google Scholar 

  23. Mortezaee K, Parwaie W, Motevaseli E et al (2019) Targets for improving tumor response to radiotherapy. Int Immunopharmacol 76:105847

    CAS  PubMed  Google Scholar 

  24. Mortezaee K, Najafi M, Farhood B et al (2019) Genomic instability and carcinogenesis of heavy charged particles radiation: clinical and environmental implications. Medicina (Kaunas) 55:591

    PubMed Central  Google Scholar 

  25. Farhood B, Hoseini-Ghahfarokhi M, Motevaseli E et al (2020) TGF-β in radiotherapy: mechanisms of tumor resistance and normal tissues injury. Pharmacol Res 155:104745

    CAS  PubMed  Google Scholar 

  26. Khodamoradi E, Hoseini-Ghahfarokhi M, Amini P et al (2020) Targets for protection and mitigation of radiation injury. Cell Mol Life Sci 77:3129–3159

    CAS  PubMed  Google Scholar 

  27. Mortezaee K, Narmani A, Salehi M et al (2021) Synergic effects of nanoparticles-mediated hyperthermia in radiotherapy/chemotherapy of cancer. Life Sci 269:119020

    CAS  PubMed  Google Scholar 

  28. Ashrafizadeh M, Zarrabi A, Samarghandian S et al (2020) PTEN: what we know of the function and regulation of this onco-suppressor factor in bladder cancer? Eur J Pharmacol 881:173226

    CAS  PubMed  Google Scholar 

  29. Ashrafizadeh M, Najafi M, Ang HL et al (2020) PTEN, a barrier for proliferation and metastasis of gastric cancer cells: from molecular pathways to targeting and regulation. Biomedicines 8:264

    CAS  PubMed Central  Google Scholar 

  30. Presa N, Gomez-Larrauri A, Dominguez-Herrera A et al (2020) Novel signaling aspects of ceramide 1-phosphate. Biochim Biophys Acta (BBA) 1865:158630

    CAS  Google Scholar 

  31. Larsen BD, Sørensen CS (2017) The caspase-activated DN ase: apoptosis and beyond. FEBS J 284:1160–1170

    CAS  PubMed  Google Scholar 

  32. D’arcy MS (2019) Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int 43:582–592

    PubMed  Google Scholar 

  33. Kretz A-L, Von Karstedt S, Hillenbrand A et al (2018) Should we keep walking along the trail for pancreatic cancer treatment? Revisiting TNF-related apoptosis-inducing ligand for anticancer therapy. Cancers 10:77

    PubMed Central  Google Scholar 

  34. Cao K, Tait SW (2018) Apoptosis and cancer: force awakens, phantom menace, or both? Int Rev Cell Mol Biol 337:135–152

    CAS  PubMed  Google Scholar 

  35. Jardim FR, De Rossi FT, Nascimento MX et al (2018) Resveratrol and brain mitochondria: a review. Mol Neurobiol 55:2085–2101

    CAS  PubMed  Google Scholar 

  36. Galati S, Boni C, Gerra MC et al (2019) Autophagy: a player in response to oxidative stress and DNA damage. Oxid Med Cell Longev. https://doi.org/10.1155/2019/5692958

    Article  PubMed  PubMed Central  Google Scholar 

  37. Miller DR, Thorburn A (2021) Autophagy and organelle homeostasis in cancer. Dev Cell 56:906–918

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Maiuri MC, Zalckvar E, Kimchi A et al (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741–752

    CAS  PubMed  Google Scholar 

  39. Smith AG, Macleod KF (2019) Autophagy, cancer stem cells and drug resistance. J Pathol 247:708–718

    PubMed  PubMed Central  Google Scholar 

  40. Yun CW, Lee SH (2018) The roles of autophagy in cancer. Int J Mol Sci 19:3466

    PubMed Central  Google Scholar 

  41. Ashrafizadeh M, Zarrabi A, Orouei S et al (2021) MicroRNA-mediated autophagy regulation in cancer therapy: the role in chemoresistance/chemosensitivity. Eur J Pharmacol 892:173660

    CAS  PubMed  Google Scholar 

  42. Vitale I, Galluzzi L, Castedo M et al (2011) Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 12:385–392

    CAS  PubMed  Google Scholar 

  43. Adjemian S, Oltean T, Martens S et al (2020) Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death. Cell Death Dis 11:1–15

    Google Scholar 

  44. Prokhorova EA, Egorshina AY, Zhivotovsky B et al (2020) The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death. Oncogene 39:1–16

    CAS  PubMed  Google Scholar 

  45. Portugal J, Mansilla S, Bataller M (2010) Mechanisms of drug-induced mitotic catastrophe in cancer cells. Curr Pharm Des 16:69–78

    CAS  PubMed  Google Scholar 

  46. Kobayashi D, Oike T, Shibata A et al (2017) Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin. Sci Rep 7:1–8

    Google Scholar 

  47. Mc Gee MM (2015) Targeting the mitotic catastrophe signaling pathway in cancer. Mediat Inflamm 2015:146282

    Google Scholar 

  48. Gewirtz DA, Holt SE, Elmore LW (2008) Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 76:947–957

    CAS  PubMed  Google Scholar 

  49. Wunderlich R, Ruehle P-F, Deloch L et al (2017) Interconnection between DNA damage, senescence, inflammation, and cancer. Front Biosci 22:348–369

    CAS  Google Scholar 

  50. Campisi J, Kim S-H, Lim C-S et al (2001) Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 36:1619–1637

    CAS  PubMed  Google Scholar 

  51. Nardella C, Clohessy JG, Alimonti A et al (2011) Pro-senescence therapy for cancer treatment. Nat Rev Cancer 11:503–511

    CAS  PubMed  Google Scholar 

  52. Acosta JC, Gil J (2012) Senescence: a new weapon for cancer therapy. Trends Cell Biol 22:211–219

    CAS  PubMed  Google Scholar 

  53. Amaravadi RK, Thompson CB (2007) The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res 13:7271–7279

    CAS  PubMed  Google Scholar 

  54. Salehi B, Mishra AP, Nigam M et al (2018) Resveratrol: a double-edged sword in health benefits. Biomedicines 6:91

    CAS  PubMed Central  Google Scholar 

  55. Ashrafizadeh M, Taeb S, Haghi-Aminjan H et al (2020) Resveratrol as an enhancer of apoptosis in cancer: a mechanistic review. Anti-cancer Agents Med Chem. https://doi.org/10.2174/1871520620666201020160348

    Article  Google Scholar 

  56. Mortezaee K, Najafi M, Farhood B et al (2020) Resveratrol as an adjuvant for normal tissues protection and tumor sensitization. Curr Cancer Drug Targets 20:130–145

    CAS  PubMed  Google Scholar 

  57. Ahmadi Z, Mohammadinejad R, Ashrafizadeh M (2019) Drug delivery systems for resveratrol, a non-flavonoid polyphenol: emerging evidence in last decades. J Drug Deliv Sci Technol 51:591–604

    CAS  Google Scholar 

  58. Ashrafizadeh M, Ahmadi Z, Farkhondeh T et al (2020) Resveratrol targeting the Wnt signaling pathway: a focus on therapeutic activities. J Cell Physiol 235:4135–4145

    CAS  PubMed  Google Scholar 

  59. Ashrafizadeh M, Javanmardi S, Moradi-Ozarlou M et al (2020) Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol. Biosci Rep. https://doi.org/10.1042/BSR20200257

  60. Senthil Kumar C, Thangam R, Mary SA et al (2020) Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells. Carbohydr Polym 231:115682

    CAS  PubMed  Google Scholar 

  61. Summerlin N, Soo E, Thakur S et al (2015) Resveratrol nanoformulations: challenges and opportunities. Int J Pharm 479:282–290

    CAS  PubMed  Google Scholar 

  62. Amini P, Nodooshan SJ, Ashrafizadeh M et al (2020) Resveratrol induces apoptosis and attenuates proliferation of MCF-7 cells in combination with radiation and hyperthermia. Curr Mol Med. https://doi.org/10.2174/1566524020666200521080953

    Article  Google Scholar 

  63. Zhang Y, Yang S, Yang Y et al (2019) Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells. Infect Agents Cancer 14:27

    Google Scholar 

  64. Chhabra G, Singh CK, Amiri D et al (2021) Recent advancements on immunomodulatory mechanisms of resveratrol in tumor microenvironment. Molecules (Basel, Switzerland) 26:1343

    CAS  Google Scholar 

  65. Chen Q, Ganapathy S, Singh KP et al (2010) Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS ONE 5:e15288

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Wang Z, Wu L, Tong S et al (2016) Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway. Anim Cells Syst 20:77–85

    Google Scholar 

  67. Chai R, Fu H, Zheng Z et al (2017) Resveratrol inhibits proliferation and migration through SIRT1 mediated post-translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells. Mol Med Rep 16:8037–8044

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Jin X, Wei Y, Liu Y et al (2019) Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial–mesenchymal transition and modulating SIRT1/β-catenin signaling pathway in breast cancer. Cancer Med 8:1246–1257

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Xu L, Botchway BO, Zhang S et al (2018) Inhibition of NF-κB signaling pathway by resveratrol improves spinal cord injury. Front Neurosci 12:690

    PubMed  PubMed Central  Google Scholar 

  70. Mortezaee K, Najafi M, Farhood B et al (2019) NF-kappaB targeting for overcoming tumor resistance and normal tissues toxicity. J Cell Physiol 234:17187–17204

    CAS  PubMed  Google Scholar 

  71. Kotha A, Sekharam M, Cilenti L et al (2006) Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5:621

    CAS  PubMed  Google Scholar 

  72. Li D, Wang G, Jin G et al (2019) Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. Int J Mol Med 43:630–640

    CAS  PubMed  Google Scholar 

  73. Baek SH, Ko J-H, Lee H et al (2016) Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine 23:566–577

    CAS  PubMed  Google Scholar 

  74. Ma X, Tian X, Huang X et al (2007) Resveratrol-induced mitochondrial dysfunction and apoptosis are associated with Ca 2+ and mCICR-mediated MPT activation in HepG2 cells. Mol Cell Biochem 302:99–109

    CAS  PubMed  Google Scholar 

  75. Sareen D, Darjatmoko SR, Albert DM et al (2007) Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer. Mol Pharmacol 72:1466–1475

    CAS  PubMed  Google Scholar 

  76. Liu Z, Wu X, Lv J et al (2019) Resveratrol induces p53 in colorectal cancer through SET7/9. Oncol Lett 17:3783–3789

    CAS  PubMed  PubMed Central  Google Scholar 

  77. Tian Y, Song W, Li D et al (2019) Resveratrol as a natural regulator of autophagy for prevention and treatment of cancer. Onco Targets Ther 12:8601–8609

    CAS  PubMed  PubMed Central  Google Scholar 

  78. Kueck A, Opipari AW, Griffith KA et al (2007) Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol 107:450–457

    CAS  PubMed  Google Scholar 

  79. Zhang J, Chiu J, Zhang H et al (2013) Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells. Biochem Pharmacol 86:317–328

    CAS  PubMed  Google Scholar 

  80. Chang C-H, Lee C-Y, Lu C-C et al (2017) Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: a key role of AMPK and Akt/mTOR signaling. Int J Oncol 50:873–882

    CAS  PubMed  Google Scholar 

  81. Miki H, Uehara N, Kimura A et al (2012) Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. Int J Oncol 40:1020–1028

    CAS  PubMed  PubMed Central  Google Scholar 

  82. García-Zepeda SP, García-Villa E, Díaz-Chávez J et al (2013) Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy. Eur J Cancer Prev 22:577–584

    PubMed  Google Scholar 

  83. Lang F, Qin Z, Li F et al (2015) Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells. PLoS ONE 10:e0129196

    PubMed  PubMed Central  Google Scholar 

  84. Wang H, Peng Y, Wang J et al (2018) Effect of autophagy on the resveratrol-induced apoptosis of ovarian cancer SKOV3 cells. J Cell Biochem 120:7788–7793

    Google Scholar 

  85. Yu J, Parkhitko A, Henske EP (2011) Autophagy: an ‘Achilles’ heel of tumorigenesis in TSC and LAM. Autophagy 7:1400–1401

    CAS  PubMed  PubMed Central  Google Scholar 

  86. He X, Wang Y, Zhu J et al (2011) Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett 301:168–176

    CAS  PubMed  Google Scholar 

  87. Alayev A, Sun Y, Snyder RB et al (2014) Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell Cycle (Georgetown, Tex.) 13:371–382

    CAS  Google Scholar 

  88. Filippi-Chiela EC, Thomé MP, Bueno e Silva MM et al (2013) Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells. BMC Cancer 13:147

    CAS  PubMed  PubMed Central  Google Scholar 

  89. Young LF, Martin KR (2006) Time-dependent resveratrol-mediated mRNA and protein expression associated with cell cycle in WR-21 cells containing mutated human c-Ha-Ras. Mol Nutr Food Res 50:70–77

    CAS  PubMed  Google Scholar 

  90. Traversi G, Fiore M, Percario Z et al (2017) The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis. Mol Carcinog 56:1117–1126

    CAS  PubMed  Google Scholar 

  91. Farhood B, Goradel NH, Mortezaee K et al (2019) Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation. J Cell Commun Signal 13:3–16

    PubMed  Google Scholar 

  92. Giménez-Bastida JA, Ávila-Gálvez MÁ, Espín JC et al (2019) Conjugated physiological resveratrol metabolites induce senescence in breast cancer cells: role of p53/p21 and p16/Rb pathways, and ABC transporters. Mol Nutr Food Res 63:1900629

    Google Scholar 

  93. Chen K-Y, Chen C-C, Chang Y-C et al (2019) Resveratrol induced premature senescence and inhibited epithelial-mesenchymal transition of cancer cells via induction of tumor suppressor Rad9. PLoS ONE 14:e0219317

    CAS  PubMed  PubMed Central  Google Scholar 

  94. Ji S, Zheng Z, Liu S et al (2018) Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. Exp Cell Res 370:292–302

    CAS  PubMed  Google Scholar 

  95. Li B, Hou D, Guo H et al (2017) Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells. Sci Rep 7:208

    CAS  PubMed  PubMed Central  Google Scholar 

  96. Fang Y, Demarco VG, Nicholl MB (2012) Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103:1090–1098

    CAS  PubMed  PubMed Central  Google Scholar 

  97. Sayd S, Thirant C, El-Habr EA et al (2014) Sirtuin-2 activity is required for glioma stem cell proliferation arrest but not necrosis induced by resveratrol. Stem Cell Rev Rep 10:103–113

    CAS  PubMed  Google Scholar 

  98. Alobaedi OH, Talib WH, Basheti IA (2017) Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pac J Trop Med 10:400–408

    CAS  PubMed  Google Scholar 

  99. San Hipólito-Luengo Á, Alcaide A, Ramos-González M et al (2017) Dual effects of resveratrol on cell death and proliferation of colon cancer cells. Nutr Cancer 69:1019–1027

    PubMed  Google Scholar 

  100. Scifo C, Cardile V, Russo A et al (2004) Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells. Oncol Res 14:415–426

    PubMed  Google Scholar 

  101. Scifo C, Milasi A, Guarnera A et al (2005) Resveratrol and propolis extract: an insight into the morphological and molecular changes induced in DU145 cells. Oncol Res 15:409–421

    CAS  Google Scholar 

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Acknowledgements

Supported by Cooperative Foundation of Shaoyang University.

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  1. College of Basic Medicine, Shaoyang University, Shaoyang, 422000, China

    Xiao Fu & Mu Li

  2. Department of Obstetrics and Gynecology of the Second Affiliated Hospital, Shaoyang University, Shaoyang, 422000, China

    Cuilian Tang

  3. Shaoyang Key Laboratory of Molecular Biology Diagnosis, Shaoyang, 422000, China

    Zezhi Huang

  4. Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Masoud Najafi

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  1. Xiao Fu
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  3. Cuilian Tang
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  4. Zezhi Huang
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All authors were involved in the preparing first draft. The scientific edition performed by MN. All authors wrote and approved the article.

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Fu, X., Li, M., Tang, C. et al. Targeting of cancer cell death mechanisms by resveratrol: a review. Apoptosis 26, 561–573 (2021). https://doi.org/10.1007/s10495-021-01689-7

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