Skip to main content
Log in

Letter to the editor: iron, apoptosis, and ferroptosis

  • Letter to the Editor
  • Published:
Apoptosis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Fukuchi K, Tomoyasu S, Tsuruoka N, Gomi K (1994) Iron deprivation-induced apoptosis in HL-60 cells. FEBS Lett 350:139–142

    Article  CAS  Google Scholar 

  2. Hirschhorn T, Stockwell BR (2019) The development of the concept of ferroptosis. Free Radic Biol Med 133:130–143

    Article  CAS  Google Scholar 

  3. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B III, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072

    Article  CAS  Google Scholar 

  4. Ghio AJ, Tong H, Soukup JM, Dailey LA, Cheng WY, Samet JM, Kesic MJ, Bromberg PA, Turi JL, Upadhyay D, Scott Budinger GR, Mutlu GM (2013) Sequestration of mitochondrial iron by silica particle initiates a biological effect. Am J Physiol Lung Cell Mol Physiol 305:L712–L724

    Article  CAS  Google Scholar 

  5. Horniblow RD, Henesy D, Iqbal TH, Tselepis C (2017) Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Mol Nutr Food Res 61(3):1600692

    Article  Google Scholar 

  6. Yu H, Yang C, Jian L, Guo S, Chen R, Li K, Qu F, Tao K, Fu Y, Luo F, Liu S (2019) Sulfasalazine induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor. Oncol Rep 42:826–838

    PubMed  Google Scholar 

  7. Droke EA, Briske-Anderson M, Lukaski HC (2003) Fatty acids alter monolayer integrity, paracellular transport, and iron uptake and transport in Caco-2 cells. Biol Trace Elem Res 95:219–232

    Article  CAS  Google Scholar 

  8. Hisakawa N, Nishiya K, Tahara K, Matsumori A, Hashimoto K (1998) Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts. Ann Rheum Dis 57:742–746

    Article  CAS  Google Scholar 

  9. Tanji K, Imaizumi T, Matsumiya T, Itaya H, Fujimoto K, Cui X, Toki T, Ito E, Yoshida H, Wakabayashi K, Satoh K (2001) Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line. Biochim Biophys Acta 1530:227–235

    Article  CAS  Google Scholar 

  10. Lall MM, Ferrell J, Nagar S, Fleisher LN, McGahan MC (2008) Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase. Investig Ophthalmol Vis Sci 49:310–319

    Article  Google Scholar 

  11. Berndt C, Lillig CH (2017) Glutathione, glutaredoxins, and iron. Antioxid Redox Signal 27:1235–1251

    Article  CAS  Google Scholar 

  12. Inoue H, Hanawa N, Katsumata SI, Katsumata-Tsuboi R, Takahashi N, Uehara M (2017) Iron deficiency induces autophagy and activates Nrf2 signal through modulating p62/SQSTM. Biomed Res 38:343–350

    Article  CAS  Google Scholar 

  13. Yang ND, Tan SH, Ng S, Shi Y, Zhou J, Tan KS, Wong W-SF, Shen H-M (2014) Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem 289:33425–33441

    Article  CAS  Google Scholar 

  14. Ou W, Mulik RS, Anwar A, McDonald JG, He X, Corbin IR (2017) Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma. Free Radic Biol Med 112:597–607

    Article  CAS  Google Scholar 

  15. Jung IR, Choi SE, Jung JG, Lee SA, Han SJ, Kim HJ, Kim DJ, Lee K-W, Kang Y (2015) Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells. Mol Cell Endocrinol 407:74–84

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew J. Ghio.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ghio, A.J. Letter to the editor: iron, apoptosis, and ferroptosis. Apoptosis 25, 605–606 (2020). https://doi.org/10.1007/s10495-020-01628-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10495-020-01628-y

Navigation