, Volume 24, Issue 1–2, pp 3–20 | Cite as

TAK1 mediates convergence of cellular signals for death and survival

  • Sabreena AashaqEmail author
  • Asiya Batool
  • Khurshid I. Andrabi


TGF-β activated kinase 1, a MAPK kinase kinase family serine threonine kinase has been implicated in regulating diverse range of cellular processes that include embryonic development, differentiation, autophagy, apoptosis and cell survival. TAK1 along with its binding partners TAB1, TAB2 and TAB3 displays a complex pattern of regulation that includes serious crosstalk with major signaling pathways including the C-Jun N-terminal kinase (JNK), p38 MAPK, and I-kappa B kinase complex (IKK) involved in establishing cellular commitments for death and survival. This review also highlights how TAK1 orchestrates regulation of energy homeostasis via AMPK and its emerging role in influencing mTORC1 pathway to regulate death or survival in tandem.


Apoptosis Autophagy Cytokine Inflammatory Smad 



Infrastructure grants in favour of Khurshid I. Andrabi under DST-SERB are gratefully acknowledged. Individual fellowships in favour of Sabreena Aashaq (23-12/2012) from University Grant Commission (UGC) New Delhi, India, and Asiya Batool (140150/2014) from Department of Science and Technology are highly acknowledged.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest regarding the publication of this paper.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Sabreena Aashaq
    • 1
    Email author
  • Asiya Batool
    • 1
  • Khurshid I. Andrabi
    • 1
  1. 1.Department of BiotechnologyUniversity of KashmirSrinagarIndia

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