Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks

Abstract

Pim kinases are being implicated in oncogenic process in various human cancers. Pim kinases primarily deal with three broad categories of functions such as tumorigenesis, protecting cells from apoptotic signals and evading immune attacks. Here in this review, we discuss the regulation of Pim kinases and their expression, and how these kinases defend cancer cells from therapeutic and immune attacks with special emphasis on how Pim kinases maintain their own expression during apoptosis and cellular transformation, defend mitochondria during apoptosis, defend cancer cells from immune attack, defend cancer cells from therapeutic attack, choose localization, self-regulation, activation of oncogenic transcription, metabolic regulation and so on. In addition, we also discuss how Pim kinases contribute to tumorigenesis by regulating cellular transformation and glycolysis to reinforce the importance of Pim kinases in cancer and cancer stem cells.

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Acknowledgments

The authors sincerely thank UT MD Anderson Cancer Center for literature access.

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Correspondence to Goodwin G. Jinesh.

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Jinesh, G.G., Mokkapati, S., Zhu, K. et al. Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks. Apoptosis 21, 1203–1213 (2016). https://doi.org/10.1007/s10495-016-1289-3

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Keywords

  • Blebbishields
  • ROS
  • Mitochondria
  • VEGF
  • CXCR4
  • P-glycoprotein