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Membrane lipid rafts and estrogenic signalling: a functional role in the modulation of cell homeostasis

  • THE ROLE OF SPHINGOLIPIDS AND LIPID RAFTS IN DETERMINING CELL FATE
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Abstract

It has become widely accepted that along with their ability to directly regulate gene expression, estrogens also influence cell signalling and cell function via rapid membrane-initiated events. Many of these signalling processes are dependent on estrogen receptors (ER) localized to the plasma membrane. However, the mechanisms by which ER are able to trigger cell signalling when targeted to the membrane surface have to be determined yet. Lipid rafts seem to be essential for the plasma membrane localization of ER and play a critical role in their membrane-initiated effects. In this review, we briefly recapitulate the localization and function of ER in different cell types and mostly discuss the possible role of lipid rafts in this context. Further studies in this field may disclose new promising therapeutic avenues by the disruption of lipid rafts in those diseases in which membrane ER activation has been demonstrated to play a pathogenetic role.

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Authors and Affiliations

  1. Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

    Angela Maselli, Marina Pierdominici & Elena Ortona

  2. Centro di Ricerca Clinica e Sperimentale IRCCS San Raffaele, Rome, Italy

    Cristiana Vitale & Elena Ortona

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  1. Angela Maselli
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  2. Marina Pierdominici
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  3. Cristiana Vitale
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  4. Elena Ortona
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Correspondence to Elena Ortona.

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Maselli, A., Pierdominici, M., Vitale, C. et al. Membrane lipid rafts and estrogenic signalling: a functional role in the modulation of cell homeostasis. Apoptosis 20, 671–678 (2015). https://doi.org/10.1007/s10495-015-1093-5

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