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Hijacking of death receptor signaling by bacterial pathogen effectors

  • The Domains of Apoptosis and Inflammation
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Abstract

Death receptors such as Tumor necrosis factor receptor 1, FAS and TNF-associated apoptosis-inducing ligand-R1/2 play a major role in counteracting with bacterial pathogen infection through regulation of inflammation and programmed cell death. The highly regulated death receptor signaling is frequently targeted by gram-negative bacterial pathogens such as Salmonella, Shigella, enteropathogenic Escherichia coli and enterohamorrhagic Escherichia coli, which harbor a conserved type III secretion system that delivers a repertoire of effector proteins to manipulate host signal transductions for their own benefit. This review focuses on how bacterial gut pathogens hijack death receptor signaling to inhibit host NF-κB and programmed cell death pathways.

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Acknowledgments

We apologize to colleagues whose work could not be cited owing to space limitations and the defined focus of the review. Work in Dr. Shan Li’s laboratory is supported by the National Natural Science Foundation of China (NSFC) NO. 31470245 to S.L.

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Authors and Affiliations

  1. Taihe Hospital, Hubei University of Medicine, #32 Renmin South Rd, Shiyan, 442000, Hubei, China

    Jie Luo, Yong Zhang, Qing Hu & Shan Li

  2. Institute of Medicine and Nursing, Hubei University of Medicine, Shiyan, 442000, Hubei, China

    Jiaqingzi Hu

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  1. Jie Luo
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  2. Jiaqingzi Hu
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  3. Yong Zhang
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  4. Qing Hu
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Correspondence to Shan Li.

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Luo, J., Hu, J., Zhang, Y. et al. Hijacking of death receptor signaling by bacterial pathogen effectors. Apoptosis 20, 216–223 (2015). https://doi.org/10.1007/s10495-014-1068-y

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