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Peripheral survival of naïve CD8+ T cells

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Abstract

Maintenance of a sufficient population of naïve CD8+ T cells in the peripheral lymphoid compartment is critical for immunocompetence. Peripheral T cell number is a function of T cell generation, survival, and death. Homeostasis, a critical balance between survival and death, must exist to prevent either lymphopenia or lymphocytosis. In the current review, we discuss known requirements for the survival of naïve peripheral CD8+ T cells as well as mechanisms of death when survival signals are lost. We also discuss associations between survival and homeostasis-driven proliferation, and highlight the gaps in our knowledge of these critical processes.

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Authors and Affiliations

  1. The Department of Pathology, The University of Chicago, 5841 S. Maryland Ave, Chicago, IL, 60637, USA

    I. E. Brown, M. Markiewicz & T. F. Gajewski MD, PhD

  2. Department of Medicine, 5841 S. Maryland Ave, Chicago, IL, 60637, USA

    M. Mashayekhi, M.-L. Alegre & T. F. Gajewski MD, PhD

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  1. I. E. Brown
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  2. M. Mashayekhi
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  4. M.-L. Alegre
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  5. T. F. Gajewski MD, PhD
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Correspondence to T. F. Gajewski MD, PhD.

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Brown, I.E., Mashayekhi, M., Markiewicz, M. et al. Peripheral survival of naïve CD8+ T cells. Apoptosis 10, 5–11 (2005). https://doi.org/10.1007/s10495-005-6056-9

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