Potentially Inappropriate Antidepressant Prescriptions Among Older Adults in Office-Based Outpatient Settings: National Trends from 2002 to 2012
Using data from 2002 to 2012 National Ambulatory Medical Care Survey, we estimated that the prevalence of overall antidepressant prescriptions increased almost twofold from 5.2% in 2002 to 10.1% in 2012 in office-based outpatient visits made by older adults. In addition, older adults were exposed to the risk of potentially avoidable adverse drug events in approximately one in ten antidepressant-related visits, or 2.2 million visits annually. Amitriptyline and doxepin were the two most frequent disease-independent potentially inappropriate antidepressants. Racial/ethnic minorities, and Medicaid beneficiaries had higher odds of potentially inappropriate antidepressant prescriptions (P < 0.05). Efforts to minimize potentially inappropriate antidepressant prescriptions are needed.
KeywordsAntidepressant Office-based care Older adults Beers Criteria Inappropriate use Prescribing pattern
This study was funded to Dr. Rhee in part by St. Peter and Leiner Family Outcomes Research Fellowship, University of Minnesota College of Pharmacy.
Publicly available data were obtained from the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC). Analyses, interpretation, and conclusions are solely those of the authors and do not necessarily reflect the views of the Division of Health Interview Statistics or NCHS of the CDC.
Dr. TGR conceived the study, acquired data, analyzed and interpreted the data, led the writing of the manuscript, and oversaw every aspect of the study. Drs. JCS, BDC, RLH, and DLU contributed to the interpretation of the data, and critically revised the manuscript.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they do not have a conflict of interest.
Using publicly available de-identified data, the research procedure for this study was exempted from the University of Minnesota Institutional Review Board.
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