Applied Psychophysiology and Biofeedback

, Volume 41, Issue 1, pp 103–110 | Cite as

The Efficacy of Neurofeedback in Patients with Major Depressive Disorder: An Open Labeled Prospective Study

  • Eun-Jin Cheon
  • Bon-Hoon KooEmail author
  • Joong-Hyun Choi


The purpose of this study was to evaluate the effect of neurofeedback on depressive symptoms and electrophysiological disturbances in patients with major depressive disorder. We recruited participants suffering from depression to evaluate efficacy of left prefrontal beta with alpha/theta training. An 8-week, prospective, open-label study was undertaken. Twenty participants were recruited. The treatment protocol was twice or three times a week training of beta at F3 with alpha/theta at Pz for 8 weeks. When every visit, patients were received beta training for 30 min, and then alpha/theta training for 30 min. Baseline, 4 and 8 week scores of; the Hamilton rating scale for Depression (HAM-D), the Hamilton rating scale for Anxiety (HAM-A), the Beck Depression Inventory (BDI)-II, the Beck Anxiety Inventory (BAI), Clinical global impression-severity (CGI-S), and pre- and post-treatment resting state EEGs were compared. Interhemispheric alpha power asymmetry (A score) was computed for homologous sites F3–F4. Pre- and post-training clinical assessments revealed significant improvements in HAM–D, HAM-A, BDI, and CGI-S scores. Cumulative response rates by HAM-D were 35.0 and 75.0 % at 4 and 8 weeks, respectively, corresponding cumulative remission rates by HAM-D were 15.0 and 55.0 %, respectively. No significant differences were found between pre- and post-treatment A score. Neurofeedback treatment could improve depressive symptoms significantly. In addition, anxiety symptoms and clinical illness severity decreased significantly after neurofeedback treatment. Despite its several limitations, such as, small sample size and lack of a control group, this study suggested neurofeedback has significant effects in patients with major depressive disorder.


Neurofeedback Beta training Depression Asymmetry score 



This work was supported by a Yeungnam University Research Grant (2012). We deeply appreciate to our colleagues, Dai-Seg Bai Ph.D., Hye-Guem Kim M.D., Young-Ji Lee M.D., Seung-Woo Lee, M.D., Jae-Hwa Choi M.D., Su-Hong Ha M.A. for helping in this study.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of PsychiatryYeungnam University College of Medicine,Yeungnam University Medical CenterDaeguRepublic of Korea
  2. 2.Department of PsychologyYeungnam University College of Medicine,Yeungnam University Medical CenterDaeguRepublic of Korea

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