Heart Rate Variability: A Risk Factor for Female Sexual Dysfunction
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Heart rate variability (HRV) is a measure of autonomic nervous system activity, which reflects an individual’s ability to adapt to physiological and environmental changes. Low resting HRV has been linked to several mental health conditions, including depression, anxiety, and alcohol dependence (Kemp et al. in Biological Psychiatry 67(11):1067–1074, 2010. doi:10.1016/j.biopsych.2009.12.012; Kemp et al. in PloS One, 7(2):e30777, 2012; Quintana et al. in Drug and Alcohol Dependence, 132(1–2):395–398, 2013. doi:10.1016/j.drugalcdep.2013.02.025). HRV has also been used as a method for indexing the relative balance of sympathetic nervous system (SNS) activity to parasympathetic nervous system activity. This balance—in particular, moderately dominant SNS activity—has been shown to play a significant role in women’s genital sexual arousal in the laboratory; however, the role of SNS activity in clinically relevant sexual arousal function is unknown. The present study assessed the feasibility of using HRV as an index of women’s self-reported sexual arousal function outside the laboratory. Sexual arousal function, overall sexual function, and resting HRV were assessed in 72 women, aged 18–39. Women with below average HRV were significantly more likely to report sexual arousal dysfunction (p < .001) and overall sexual dysfunction (p < .001) than both women with average HRV and women with above average HRV. In conclusion, low HRV may be a risk factor for female sexual arousal dysfunction and overall sexual dysfunction.
KeywordsHeart rate variability Sympathetic nervous system Female sexual dysfunction Female sexual arousal
This research was supported by a grant from the National Institute of Child Health and Human Development (NICHD, RO1 HD051676) to Cindy M. Meston. Tierney A. Lorenz was supported by a grant from the NICHD (T32HD049336). The views presented here are solely those of the authors and do necessarily not represent the official views of the National Institutes of Health.
- Billups, K. L., Bank, A. J., Padma-Nathan, H., Katz, S., & Williams, R. (2005). Erectile dysfunction is a marker for cardiovascular disease: results of the minority health institute expert advisory panel. The Journal of Sexual Medicine, 2(1), 40–50; discussion 50–52. doi: 10.1111/j.1743-6109.2005.20104_1.x.
- Bloemers, J., Gerritsen, J., Bults, R., Koppeschaar, H., Everaerd, W., Olivier, B., & Tuiten, A. (2010). Induction of sexual arousal in women under conditions of institutional and ambulatory laboratory circumstances: a comparative study. The Journal of Sexual Medicine, 7(3), 1160–1176. doi: 10.1111/j.1743-6109.2009.01660.x.PubMedCrossRefGoogle Scholar
- Fernandez, E. A., Neto, E. P. S., Abry, P., Macchiavelli, R., Balzarini, M., Cuzin, B., et al. (2010). Assessing erectile neurogenic dysfunction from heart rate variability through a generalized linear mixed model framework. Computer Methods and Programs in Biomedicine, 99(1), 49–56. doi: 10.1016/j.cmpb.2009.11.001.PubMedCrossRefGoogle Scholar
- Kemp, A. H., & Quintana, D. S. (2013). The relationship between mental and physical health: Insights from the study of heart rate variability. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 89(3), 288–296. doi: 10.1016/j.ijpsycho.2013.06.018.CrossRefGoogle Scholar
- Kemp, A. H., Quintana, D. S., Felmingham, K. L., Matthews, S., & Jelinek, H. F. (2012). Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: Implications for cardiovascular risk. PLoS One, 7(2), e30777. doi: 10.1371/journal.pone.0030777.PubMedCentralPubMedCrossRefGoogle Scholar
- Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010). Impact of depression and antidepressant treatment on heart rate variability: A review and meta-analysis. Biological Psychiatry, 67(11), 1067–1074. doi: 10.1016/j.biopsych.2009.12.012.PubMedCrossRefGoogle Scholar
- Lorenz, T. A., Harte, C. B., Hamilton, L. D., & Meston, C. M. (2012). Evidence for a curvilinear relationship between sympathetic nervous system activation and women’s physiological sexual arousal. Psychophysiology, 49(1), 111–117. doi: 10.1111/j.1469-8986.2011.01285.x.PubMedCentralPubMedCrossRefGoogle Scholar
- McVary, K. (2006). Lower urinary tract symptoms and sexual dysfunction: Epidemiology and pathophysiology. BJU International, 97 (Suppl 2), 23–28; discussion 44–45. doi: 10.1111/j.1464-410X.2006.06102.x.
- Montorsi, P., Ravagnani, P. M., Galli, S., Rotatori, F., Briganti, A., Salonia, A., et al. (2005). The artery size hypothesis: A macrovascular link between erectile dysfunction and coronary artery disease. The American Journal of Cardiology, 96(12B), 19M–23M. doi: 10.1016/j.amjcard.2005.07.006.PubMedCrossRefGoogle Scholar
- Quintana, D. S., Guastella, A. J., McGregor, I. S., Hickie, I. B., & Kemp, A. H. (2013). Heart rate variability predicts alcohol craving in alcohol dependent outpatients: Further evidence for HRV as a psychophysiological marker of self-regulation. Drug and Alcohol Dependence, 132(1–2), 395–398. doi: 10.1016/j.drugalcdep.2013.02.025.PubMedCrossRefGoogle Scholar
- Rosen, R., Brown, C., Heiman, J., Leiblum, S., Meston, C., Shabsigh, R., et al. (2000). The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex and Marital Therapy, 26(2), 191–208. doi: 10.1080/009262300278597.PubMedCrossRefGoogle Scholar
- Thompson, I. M., Tangen, C. M., Goodman, P. J., Probstfield, J. L., Moinpour, C. M., & Coltman, C. A. (2005). Erectile dysfunction and subsequent cardiovascular disease. JAMA, the Journal of the American Medical Association, 294(23), 2996–3002. doi: 10.1001/jama.294.23.2996.PubMedCrossRefGoogle Scholar