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A novel antibiotic produced by streptomyces noursei Da07210

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Abstract

A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide. Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine sarcoma, and the IC50 values were 0.77 and 0.74 μg/ml, respectively.

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Acknowledgments

This work was supported by National Non-profit Institute Research Grant (ITBBZX2008-2-1 and ITBBZX2008-2-4), the National High Technology Research and Development Program of China (863 Program) (2007AA09Z447) and the Hainan Province Natural Science Foundation (080146).

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Authors and Affiliations

  1. Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People’s Republic of China

    Xiaopeng Wu, Huiqin Huang, Qianguang Sun, Jie Peng, Jun Zhu & Shixiang Bao

  2. Department of Chemistry, Hainan Normal University, Haikou, People’s Republic of China

    Guangying Chen

Authors
  1. Xiaopeng Wu
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  2. Huiqin Huang
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  3. Guangying Chen
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  4. Qianguang Sun
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  5. Jie Peng
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  6. Jun Zhu
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  7. Shixiang Bao
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Correspondence to Shixiang Bao.

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Wu, X., Huang, H., Chen, G. et al. A novel antibiotic produced by streptomyces noursei Da07210. Antonie van Leeuwenhoek 96, 109–112 (2009). https://doi.org/10.1007/s10482-009-9333-8

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  • DOI: https://doi.org/10.1007/s10482-009-9333-8

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