Marine actinomycete diversity and natural product discovery


Microbial natural products remain an important resource for drug discovery yet the microorganisms inhabiting the world’s oceans have largely been overlooked in this regard. The recent discovery of novel secondary metabolites from taxonomically unique populations of marine actinomycetes suggests that these bacteria add an important new dimension to microbial natural product research. Continued efforts to characterize marine actinomycete diversity and how adaptations to the marine environment affect secondary metabolite production will create a better understanding of the potential utility of these bacteria as a source of useful products for biotechnology.

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  1. S.D. Bentley K.F. Chater et al. (2002) ArticleTitleComplete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) Nature 417 141 Occurrence Handle10.1038/417141a Occurrence Handle12000953

    Article  PubMed  Google Scholar 

  2. J.W. Blunt B.R. Copp M.G.H. Munro P.T. Northcote M.R. Prinsep (2004) ArticleTitleMarine natural products Nat. Prod. Rep. 21 1–49

    Google Scholar 

  3. J.A. Colquhoun J. Mexson M. Goodfellow A.C. Ward K. Horikoshi A.T. Bull (1998) ArticleTitleNovel rhodococci and other mycolate actinomycetes from the deep sea Antonie van Leeuwenhoek 74 27–40

    Google Scholar 

  4. M. Goodfellow J.A. Haynes (1984) Actinomycetes in marine sediments L. Ortiz-Ortiz L.F. Bojalil V. Yakoleff (Eds) Biological, Biochemical, and Biomedical Aspects of Actinomycetes Academic Press New York 453–472

    Google Scholar 

  5. H. He W.-D. Ding V.S. Bernan A.D. Richardson C.M. Ireland M. Greenstein G.A. Ellestad G.T. Carter (2001) ArticleTitleLomaiviticins A and B., potent antitumor antibiotics from Micromonospora lomaivitensis J. Am. Chem. Soc. 123 5362–5363

    Google Scholar 

  6. R.H. Feling G.O. Buchanan T.J. Mincer C.A. Kauffman P.R. Jensen W. Fenical (2003) ArticleTitleSalinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial sourcea marine bacterium of the new genus Salinospora Angew. Chem. Int. Ed. 42 355–357

    Google Scholar 

  7. P.R. Jensen R. Dwight W. Fenical (1991) ArticleTitleDistribution of actinomycetes in near-shore tropical marine sediments Appl. Environ. Microbiol. 57 1102–1108

    Google Scholar 

  8. M. Keller K. Zengler (2004) ArticleTitleTapping into microbial diversity Nature Rev. Microbiol. 2 141–150

    Google Scholar 

  9. H.C. Known T.J. Mincer P.R. Jensen C.A. Kauffman W. Fenical (2002) ArticleTitleWidespread and persistent populations of a major new marine actinomycete taxon in ocean sediments Appl. Environ. Microbiol. 68 5005–5011

    Google Scholar 

  10. D.J. Newman G.M. Cragg K.M. Snader (2003) ArticleTitleNatural products as sources of new drugs over the period 1981–2002 J. Nat. Prod. 66 1022–1037

    Google Scholar 

  11. J.E.M. Stach L.A. Maldonado D.G. Masson A.C. Ward M. Goodfellow A.T. Bull (2003) ArticleTitleStatistical approaches for estimating actinobacterial diversity in marine sediments Appl. Environ. Microbiol. 69 6189–6200

    Google Scholar 

  12. Y. Wang Z. Zhang (2000) ArticleTitleComparative sequence analyses reveal frequent occurrence of short segments containing an abnormally high number of non-random base variations in bacterial rRNA genes Microbiology 146 2845–2854

    Google Scholar 

  13. M.G. Watve R. Tickoo M.M. Jog B.D. Bhole (2001) ArticleTitleHow many antibiotics are produced by the genus Streptomyces? Arch. Microbiol. 176 386–390

    Google Scholar 

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Correspondence to Paul R. Jensen.

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Jensen, P.R., Mincer, T.J., Williams, P.G. et al. Marine actinomycete diversity and natural product discovery. Antonie Van Leeuwenhoek 87, 43–48 (2005).

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  • Diversity
  • Marine actinomycete
  • Natural products