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Antonie van Leeuwenhoek

, Volume 87, Issue 1, pp 43–48 | Cite as

Marine actinomycete diversity and natural product discovery

  • Paul  R. JensenEmail author
  • Tracy  J. Mincer
  • Philip  G. Williams
  • William Fenical
Article

Abstract

Microbial natural products remain an important resource for drug discovery yet the microorganisms inhabiting the world’s oceans have largely been overlooked in this regard. The recent discovery of novel secondary metabolites from taxonomically unique populations of marine actinomycetes suggests that these bacteria add an important new dimension to microbial natural product research. Continued efforts to characterize marine actinomycete diversity and how adaptations to the marine environment affect secondary metabolite production will create a better understanding of the potential utility of these bacteria as a source of useful products for biotechnology.

Keywords

Diversity Marine actinomycete Natural products 

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References

  1. Bentley, S.D., Chater, K.F.,  et al. 2002Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)Nature417141CrossRefPubMedGoogle Scholar
  2. Blunt, J.W., Copp, B.R., Munro, M.G.H., Northcote, P.T., Prinsep, M.R. 2004Marine natural productsNat. Prod. Rep.21149Google Scholar
  3. Colquhoun, J.A., Mexson, J., Goodfellow, M., Ward, A.C., Horikoshi, K., Bull, A.T. 1998Novel rhodococci and other mycolate actinomycetes from the deep seaAntonie van Leeuwenhoek742740Google Scholar
  4. Goodfellow, M., Haynes, J.A. 1984Actinomycetes in marine sedimentsOrtiz-Ortiz, L.Bojalil, L.F.Yakoleff, V. eds. Biological, Biochemical, and Biomedical Aspects of ActinomycetesAcademic PressNew York453472Google Scholar
  5. He, H., Ding, W.-D., Bernan, V.S., Richardson, A.D., Ireland, C.M., Greenstein, M., Ellestad, G.A., Carter, G.T. 2001Lomaiviticins A and B., potent antitumor antibiotics from Micromonospora lomaivitensisJ. Am. Chem. Soc.12353625363Google Scholar
  6. Feling, R.H., Buchanan, G.O., Mincer, T.J., Kauffman, C.A., Jensen, P.R., Fenical, W. 2003Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial sourcea marine bacterium of the new genus SalinosporaAngew. Chem. Int. Ed.42355357Google Scholar
  7. Jensen, P.R., Dwight, R., Fenical, W. 1991Distribution of actinomycetes in near-shore tropical marine sedimentsAppl. Environ. Microbiol.5711021108Google Scholar
  8. Keller, M., Zengler, K. 2004Tapping into microbial diversityNature Rev. Microbiol.2141150Google Scholar
  9. Known, H.C., Mincer, T.J., Jensen, P.R., Kauffman, C.A., Fenical, W. 2002Widespread and persistent populations of a major new marine actinomycete taxon in ocean sedimentsAppl. Environ. Microbiol.6850055011Google Scholar
  10. Newman, D.J., Cragg, G.M., Snader, K.M. 2003Natural products as sources of new drugs over the period 1981–2002J. Nat. Prod.6610221037Google Scholar
  11. Stach, J.E.M., Maldonado, L.A., Masson, D.G., Ward, A.C., Goodfellow, M., Bull, A.T. 2003Statistical approaches for estimating actinobacterial diversity in marine sedimentsAppl. Environ. Microbiol.6961896200Google Scholar
  12. Wang, Y., Zhang, Z. 2000Comparative sequence analyses reveal frequent occurrence of short segments containing an abnormally high number of non-random base variations in bacterial rRNA genesMicrobiology14628452854Google Scholar
  13. Watve, M.G., Tickoo, R., Jog, M.M., Bhole, B.D. 2001How many antibiotics are produced by the genus Streptomyces?Arch. Microbiol.176386390Google Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Paul  R. Jensen
    • 1
    Email author
  • Tracy  J. Mincer
    • 1
  • Philip  G. Williams
    • 1
  • William Fenical
    • 1
  1. 1.Center for Marine Biotechnology and Biomedicine, Scripps Institution of OceanographyUniversity of CaliforniaSan Diego, La JollaUSA

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