Abstract
Yersinia pestis, the causative agent of bubonic and pneumonic plague, has a complex lifestyle, cycling between both arthropod and mammalian hosts. This pathogen has previously been shown to survive intracellularly within macrophages and to be capable of biofilm formation within the flea, suggesting the development of a range of strategies to ensure survival throughout its life cycle, including expression of virulence factors and tight regulation of its genes.
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M. Achtman K. Zurth C. Morelli G. Torrea A. Guiyoule E. Carniel (1999) ArticleTitle Yersinia pestis the cause of plague is a recently emerged clone of Yersinia pseudotuberculosis Proc. Natl. Acad. Sci. USA. 96 14043–14048 Occurrence Handle10570195 Occurrence Handle1:CAS:528:DyaK1MXns1Oqu7g%3D
A.W. Bacot C.J. Martin (1914) ArticleTitleObservations on the mechanism of the transmission of plague by fleas J. Hyg. Plague Suppl. 13 423–439
S. Ben-Efraim M. Aronson L. Bichowsky-Slomnicki (1961) ArticleTitleA new antigenic component of Pasteurella pestis formed under specific conditions of pH and temperature J. Bacteriol. 81 704–714 Occurrence Handle16561898 Occurrence Handle1:CAS:528:DyaF3MXpsVSgtg%3D%3D
A.L. Burroughs (1947) ArticleTitleSylvatic plague studies. The vector efficiency of nine species of plague compared with Xenopsylla cheopis J. Hyg. 45 371–396 Occurrence Handle10.1017/S0022172400014042
D.C. Cavanaugh (1971) ArticleTitleSpecific effect of temperature upon transmission of the plague bacillus by the oriental rat flea Xenopsylla cheopis Am. J. Trop. Med. Hyg. 20 264–272 Occurrence Handle5553266 Occurrence Handle1:STN:280:DyaE3M7mtlaluw%3D%3D
D.C. Cavanaugh R. Randall (1959) ArticleTitleThe role of multiplication of Pasteurella pestis in mononuclear phagocytes in the pathogenesis of flea-borne plague J. Immunol. 83 348–363 Occurrence Handle13808585 Occurrence Handle1:STN:280:DyaF3c7ivFSjtA%3D%3D
H. Chart T. Cheasty B. Rowe (1995) ArticleTitleDifferentiation of Yersinia pestis Yersinia pseudotuberculosis by SDS-PAGE analysis of lipopolysaccharide Lett. Appl. Microbiol. 20 369–370 Occurrence Handle7786503 Occurrence Handle1:CAS:528:DyaK2MXmslCgt70%3D
W.T. Chartnetzky W.W. Schuford (1985) ArticleTitleSurvival and growth of Yersinia pestis within macrophages and an effect of the loss of the 47-megadalton plasmid on growth in macrophages Infect. Immun. 47 234–241
G.R. Cornelis (2002) ArticleTitleThe Yersinia YSC-YOP ‘type III’ weaponry Nat. Rev. Mol. Cell Biol. 3 742–752 Occurrence Handle12360191 Occurrence Handle1:CAS:528:DC%2BD38XnsVGqtLw%3D
J.W. Costerton P.S. Stewart E.P. Greenberg (1999) ArticleTitleBacterial biofilms: a common cause of persistent infections Science 284 1318–1322 Occurrence Handle10.1126/science.284.5418.1318 Occurrence Handle1:CAS:528:DyaK1MXjs1Squ78%3D Occurrence Handle10334980
D.A.L. Davies (1955) ArticleTitleA specific polysaccharide of Pasteurella pestis Biochem. J. 63 105–116
D.T. Dennis K.L. Gage N. Grantz J.D. Poland E. Tikhomirov (1999) Plague manual: epidemiology, distribution, surveillance and control World Health Organisiation Geneva
Y.D. Du R. Rosqvist A. Forsberg (2002) ArticleTitleRole of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis Infect. Immun. 70 1453–1460 Occurrence Handle11854232 Occurrence Handle1:CAS:528:DC%2BD38XhsFSlsbY%3D
Elvin S.J., Williamson E.D., Scott J.C., Smith J.N., de Lema G.P., Chilla S., Clapham P., Pfeffer K., Schlondorff D. and Luckow B. 2004. Ambiguous role of CCR5 in Y. pestis infection. Nature 430: (6998), www.nature.com.
D.M. Engelthaler K.L. Gage (2000) ArticleTitleQuantities of Yersinia pestis in fleas (Siphonaptera: Pulicidae Ceratophyllidae Hystrichopsyllidae) collected from areas of known or suspected plague activity J. Med. Entomol. 37 422–426 Occurrence Handle15535587 Occurrence Handle1:STN:280:DC%2BD2crmtlOmsw%3D%3D
S. Eriksson S. Lucchini A. Thompson M. Rhen J.C.D. Hinton (2003) ArticleTitleUnravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica Mol. Microbiol. 47 103–118 Occurrence Handle12492857 Occurrence Handle1:CAS:528:DC%2BD3sXntVKiuw%3D%3D
M.J. Finegold (1969) ArticleTitlePneumonic plague in monkeys: an electron microscopic study Am. J. Pathol. 54 167–185 Occurrence Handle4974722 Occurrence Handle1:STN:280:DyaF1M7hsVSnsw%3D%3D
K.L. Gage D.T. Dennis K.A. Orloski P. Ettestad T.L. Brown P.J. Reynolds W.J. Pape C.L. Fritz L.G. Carter J.D. Stein (2000) ArticleTitleCases of cat-associated human plague in the western US, 1977– 1998 Clin. Infect. Dis. 30 893–900 Occurrence Handle10852811 Occurrence Handle1:STN:280:DC%2BD3cvisVOnsA%3D%3D
P.W. Gasper A.M. Barnes T.J. Quan J.P. Benziger L.G. Carter M.L. Beard G.O. Maupin (1993) ArticleTitlePlague (Yersinia pestis) in cats - description of experimentally induced disease J. Med. Entomol. 30 20–26 Occurrence Handle8433327 Occurrence Handle1:STN:280:DyaK3s7msVWrsg%3D%3D
J.P. Grabenstein M. Marceau C. Pujol M. Simonet J.B. Bliska (2004) ArticleTitleThe response regulator PhoP of Yersinia pseudotuberculosis is important for replication in macrophages and for virulence Infect. Immun. 72 4973–4984 Occurrence Handle15321989 Occurrence Handle1:CAS:528:DC%2BD2cXnt1Ciuro%3D
B.J. Hinnebusch (2004) Interactions of Yersinia pestis with its flea vector that lead to the transmission of plague A. Osbourne (Eds) Microbe-vector Interactions in Vector-borne Diseases Cambridge University Press Cambridge 331–343
B.J. Hinnebusch E.R. Fischer T.G. Schwan (1998) ArticleTitleEvaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature- dependent blockage of the flea J. Infect. Dis. 178 1406–1415 Occurrence Handle9780262 Occurrence Handle1:CAS:528:DyaK1cXns1Ogt7w%3D
B.J. Hinnebusch R.D. Perry T.G. Schwan (1996) ArticleTitleRole of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas Science 273 367–370 Occurrence Handle1:CAS:528:DyaK28Xktl2is7s%3D Occurrence Handle8662526
J. Hinnebusch P. Cherepanov Y. Du A. Rudolph J.D. Dixon T. Schwan A. Forsberg (2000) ArticleTitleMurine toxin of Yersinia pestis shows phospholipase D activity but is not required for virulence in mice Int. J. Med. Microbiol. 290 483–487 Occurrence Handle11111930 Occurrence Handle1:CAS:528:DC%2BD3cXovVGmsrw%3D
P.G. Hitchen J.L. Prior P.C.F. Oyston M. Panico B.W. Wren R.W. Titball H.R. Morris A. Dell (2002) ArticleTitleStructural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system Mol. Microbiol. 44 1637–1650 Occurrence Handle12067350 Occurrence Handle1:CAS:528:DC%2BD38Xlt1amtbs%3D
C. Jarrett E. Deak K.E. Isherwood P.C.F. Oyston E.R. Fischer A.R. Whitney S.D. Kobayashi F.R. DeLeo B.J. Hinnebusch (2004) ArticleTitleTransmission of Yersinia pestis from an infectious biofilm in the flea vector J. Inf. Dis. 190 783–792
K. Kawahara H. Tsukano H. Watanabe B. Lindner M. Matsuura (2002) ArticleTitleModification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature Infect. Immun. 70 4092–4098 Occurrence Handle12117916 Occurrence Handle1:CAS:528:DC%2BD38XlsFCmsb8%3D
A.N. Kir’iakova (1973) ArticleTitleLife span of fleas in burrows Parazitologiya 7 261–263 Occurrence Handle1:STN:280:CSuD1M3lvVI%3D
M. Kukkonen M. Suomalainen P. Kyllonen K. Lahteenmaki H. Lang R. Virkola I.M. Helander O. Holst T.K. Korhonen (2004) ArticleTitleLack of O-antigen is essential for plasminogen activation by Yersinia pestis Salmonella enterica Mol. Microbiol. 51 215–225 Occurrence Handle14651623 Occurrence Handle1:CAS:528:DC%2BD2cXhs1Sk
Lahteenmaki K., Kukkonen M., Jaatinen S., Suomalainen M., Soranummi H., Virkola R., Lang H. and Korhonen T.K. 2003. Yersinia pestis Pla has multiple virulence-associated functions. In: Genus Yersinia: Entering the Functional Genomic Era. Advances in Experimental Medicine and Biology, Vol. 529 pp. 141–145.
K. Lahteenmaki M. Kukkonen T.K. Korhonen (2001) ArticleTitleThe Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells FEBS Lett. 504 69–72 Occurrence Handle11522299 Occurrence Handle1:CAS:528:DC%2BD3MXmtFWitbk%3D
K. Lahteenmaki R. Virkola A. Saren L. Emody T.K. Korhonen (1998) ArticleTitleExpression of plasminogen activator Pla of Yersinia pestis enhances bacterial attachment to the mammalian extracellular matrix Infect. Immun. 66 5755–5762 Occurrence Handle9826351 Occurrence Handle1:CAS:528:DyaK1cXnvVChtbc%3D
J.W. Lillard S.W. Bearden J.D. Fetherston R.D. Perry (1999) ArticleTitleThe haemin storage (Hms(+)) phenotype of Yersinia pestis is not essential for the pathogenesis of bubonic plague in mammals Microbiol. UK. 145 197–209 Occurrence Handle1:CAS:528:DyaK1MXmtleqsg%3D%3D Occurrence Handle10.1099/13500872-145-1-197
L.E. Lindler M.S. Klempner S.C. Straley (1990) ArticleTitle Yersinia pestis pH-6 antigen - genetic, biochemical, virulence characterization of a protein Involved in the pathogenesis of bubonic plague Infect. Immun. 58 2569–2577 Occurrence Handle2164509 Occurrence Handle1:CAS:528:DyaK3cXltlShtLw%3D
L.E. Lindler B.D. Tall (1993) ArticleTitle Yersinia pestis pH-6 antigen forms fimbriae and is induced by intracellular association with macrophages Mol. Microbiol. 8 311–324 Occurrence Handle8100346 Occurrence Handle1:CAS:528:DyaK3sXks1Gqu7g%3D
J. Mecsas G. Franklin W.A. Kuziel R.R. Brubaker S. Falkow D.E. Mosier (2004) ArticleTitleCCR5 mutation and plague protection Nature 427 606 Occurrence Handle14961112 Occurrence Handle1:CAS:528:DC%2BD2cXhtFCnurs%3D
S.I. Miller A.M. Kukral J.J. Mekalanos (1989) ArticleTitleA 2-Component Regulatory System (Phop-Phoq) Controls SalmonellaTyphimurium Virulence Proc. Natl. Acad. Sci. USA. 86 5054–5058 Occurrence Handle2544889 Occurrence Handle1:CAS:528:DyaK3cXpt1KmsA%3D%3D
H.H. Mollaret (1963) ArticleTitleExperimental preservation of plague in soil Bull. Soc. Pathol. Exot. Filiales 56 1168–1182 Occurrence Handle14156818 Occurrence Handle1:STN:280:DyaF2c7hsVOksA%3D%3D
R.R. Montgomery D. Lustitani A. de Boisfleury Chevance S.E. Malawista (2004) ArticleTitleTick saliva reduces adherence and area of human neutrophils Infect. Immun. 72 2989–2884 Occurrence Handle15102811 Occurrence Handle1:CAS:528:DC%2BD2cXjslajurs%3D
Ng L.C., Forslund O., Koh S., Kuoppa K. and Sjosted A. 2003. The response of murine macrophages to infection with Yersinia pestis as revealed by DNA microarray analysis. In: Genus Yersinia: Entering the Functional Genomic Era. Advances in Experimental Medicine and Biology, Vol. 529 pp. 155–160.
P.C.F. Oyston N. Dorrell K. Williams S.R. Li M. Green R.W. Titball B.W. Wren (2000) ArticleTitleThe response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis Infect. Immun. 68 3419–3425 Occurrence Handle10816493 Occurrence Handle1:CAS:528:DC%2BD3cXjsF2js7w%3D
J. Parkhill B.W. Wren N.R. Thomson R.W. Titball M.T.G. Holden M.B. Prentice M. Sebaihia K.D. James C. Churcher K.L. Mungall S. Baker D. Basham S.D. Bentley K. Brooks A.M. Cerdeno-Tarraga T. Chillingworth A. Cronin R.M. Davies P. Davis G. Dougan T. Feltwell N. Hamlin S. Holroyd K. Jagels A.V. Karlyshev S. Leather S. Moule P.C.F. Oyston M. Quail K. Rutherford M. Simmonds J. Skelton K. Stevens S. Whitehead B.G. Barrell (2001) ArticleTitleGenome sequence of Yersinia pestisthe causative agent of plague Nature 413 523–527 Occurrence Handle10.1038/35097083 Occurrence Handle1:CAS:528:DC%2BD3MXnsFygurc%3D Occurrence Handle11586360
D. Payne D. Tatham E.D. Williamson R.W. Titball (1998) ArticleTitleThe pH 6 antigen of Yersinia pestis binds to B 1-linked galactosyl residues in glycosphingolipids Infect. Immun. 66 4545–4548 Occurrence Handle9712817 Occurrence Handle1:CAS:528:DyaK1cXlslCqsL4%3D
R.D. Perry J.D. Fetherston (1997) ArticleTitle Yersinia pestis-etiologic agent of plague Clin. Microbiol. Rev. 10 35–66 Occurrence Handle8993858 Occurrence Handle1:CAS:528:DyaK2sXotlSqtw%3D%3D
J.L. Prior P.G. Hitchen E.D. Williamson A.J. Reason H.R. Morris A. Dell B.W. Wren R.W. Titball (2001) ArticleTitleCharacterization of the lipopolysaccharide of Yersinia pestis Microbial Pathog. 30 49–57 Occurrence Handle1:CAS:528:DC%2BD3MXptlCgsg%3D%3D
J.L. Prior J. Parkhill P.G. Hitchen K.L. Mungall K. Stevens H.R. Morris A.J. Reason P.C.F. Oyston A. Dell B.W. Wren R.W. Titball (2001) ArticleTitleThe failure of different strains of Yersinia pestis to produce lipopolysaccharide O-antigen under different growth conditions is due to mutations in the O-antigen gene cluster FEMS Microbiol. Lett. 197 229–233 Occurrence Handle11313139 Occurrence Handle1:CAS:528:DC%2BD3MXislGrt7o%3D
C. Pujol J.B. Bliska (2003) ArticleTitleThe ability to replicate in macrophages is conserved between Yersinia pestis Yersinia pseudotuberculosis Infect. Immun. 71 5892–5899 Occurrence Handle14500510 Occurrence Handle1:CAS:528:DC%2BD3sXnslylur8%3D
R. Rebeil R.K. Ernst B.B. Gowen S.I. Miller B.J. Hinnebusch (2004) ArticleTitleVariation in lipid A structure in the pathogenic yersiniae Mol. Microbiol. 52 1363–1373 Occurrence Handle15165239 Occurrence Handle1:CAS:528:DC%2BD2cXkvFCltLw%3D
J.M.C. Ribeiro (1995) ArticleTitleHow Ticks Make a Living Parasitology Today 11 91–93 Occurrence Handle15275359 Occurrence Handle1:STN:280:DC%2BD2cznsVyjsw%3D%3D
D. Schnappinger S. Ehrt M.I. Voskuil Y. Liu J.A. Mangan I.M. Monahan G. Dolganov B. Efron P.D. Butcher C. Nathan G.K. Schoolnik (2003) ArticleTitleTranscriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment J. Exp. Med. 198 693–704 Occurrence Handle12953091 Occurrence Handle1:CAS:528:DC%2BD3sXntFeqt78%3D
G.B. Schoeler S.K. Wikel (2001) ArticleTitleModulation of host immunity by haematophagous arthropods Ann. Trop. Med. Parasitol. 95 755–771 Occurrence Handle11784430 Occurrence Handle1:CAS:528:DC%2BD38XltVSmsQ%3D%3D
O.A. Sodeinde Subrahmanyam Yvbk K. Stark T. Quan Y.D. Bao J.D. Goguen (1992) ArticleTitleA Surface Protease and the Invasive Character of Plague Science 258 1004–1007 Occurrence Handle1:CAS:528:DyaK3sXkvFSl Occurrence Handle1439793
J.C. Stephens D.E. Reich D.B. Goldstein H.D. Shin M.W. Smith M. Carrington C. Winkler G.A. Huttley R. Allikmets L. Schriml B. Gerrard M. Malasky M.D. Ramos S. Morlot M. Tzetis C. Oddoux F.S. di Giovine G. Nasioulas D. Chandler M. Aseev M. Hanson L. Kalaydjieva D. Glavac P. Gasparini E. Kanavakis M. Claustres M. Kambouris H. Ostrer G. Duff V. Baranov H. Sibul A. Metspalu D. Goldman N. Martin D. Duffy J. Schmidtke X. Estivill S.J. O’Brien M. Dean (1998) ArticleTitleDating the origin of the CCR5-Delta 32 AIDS-resistance allele by the coalescence of haplotypes Am. J. Hum. Gen. 62 1507–1515 Occurrence Handle1:CAS:528:DyaK1cXlslChsro%3D
S.C. Straley P.A. Harmon (1984a) ArticleTitleGrowth in mouse peritoneal-macrophages of Yersinia pestis lacking established virulence determinants Infect. Immun. 45 649–654 Occurrence Handle1:STN:280:DyaL2c3oslygtA%3D%3D
S.C. Straley P.A. Harmon (1984b) ArticleTitle Yersinia pestis Grows within phagolysosomes in mouse peritoneal-macrophages Infect. Immun. 45 655–659 Occurrence Handle1:STN:280:DyaL2c3oslygtQ%3D%3D
A.M. Talaat R. Lyons S.T. Howard S.A. Johnston (2004) ArticleTitleThe temporal expression profile of Mycobacterium tuberculosis infection in mice Proc. Natl. Acad. Sci. USA. 101 4602–4607 Occurrence Handle15070764 Occurrence Handle1:CAS:528:DC%2BD2cXjtFKisL4%3D
R.W. Titball J. Hill D.G. Lawton K.A. Brown (2003) ArticleTitle Yersinia pestis and plague Biochem. Soc. Trans. 31 104–107 Occurrence Handle10.1042/BST0310104 Occurrence Handle12546664 Occurrence Handle1:CAS:528:DC%2BD3sXptF2mtQ%3D%3D
M.A. Tito J. Miller K.F. Griffin E.D. Williamson R.W. Titball C.V. Robinson (2001) ArticleTitleMacromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry Protein Sci. 10 2408–2413 Occurrence Handle11604546 Occurrence Handle1:CAS:528:DC%2BD3MXnvV2rsLw%3D
S. Welkos K.M. Davis L.M. Pitt P.L. Worsham A.M. Friedlander (1995) ArticleTitleStudies on the contribution of the F1 capsule-associated plasmid pFra to the virulene to Yersinia pestis Contrib. Microbiol. Immunol. 13 299–305 Occurrence Handle8833858 Occurrence Handle1:CAS:528:DyaK28Xit1Crsbs%3D
B.W. Wren (2003) ArticleTitleThe yersiniae - A model genus to study the rapid evolution of bacterial pathogens Nat. Rev. Microbiol. 1 55–64 Occurrence Handle15040180 Occurrence Handle1:CAS:528:DC%2BD3sXptFWlu7o%3D
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Oyston, P.C.F., Isherwood, K.E. The many and varied niches occupied by Yersinia pestis as an arthropod-vectored zoonotic pathogen. Antonie Van Leeuwenhoek 87, 171–177 (2005). https://doi.org/10.1007/s10482-004-4619-3
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DOI: https://doi.org/10.1007/s10482-004-4619-3