A low-power RF integrated circuit for implantable sensors

  • Mohammad A. Adeeb
  • Hung Nguyen
  • Syed K. Islam
  • Mo Zhang
Mixed Signal Letter


A low-power low-voltage analog signal processing circuit has been designed, fabricated, and tested. The circuit is capable of processing an analog sensor current and producing an ASK modulated digital signal with modulating signal frequency proportional to the sensor current level. An on-chip regulator has been included to stabilize the supply voltage received from an external RF power source. The circuit can operate with a power supply as low as 1 V and consumes only about 20 µW of power, which is therefore very suitable for implantable biomedical applications. The whole chip was laid out and fabricated in a 0.35 µm bulk CMOS technology. Experimental results show good agreement with the simulation results.


Implantable sensor Telemetry Low-power Low-voltage Wireless RF CMOS ASK 


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  1. 1.
    G.L. Coté, R.M. Lec, and M.V. Pishko, “Emerging biomedical sensing technologies and their applications.” IEEE Sensors Journal, vol. 3, no. 3, pp. 251–266, 2003.Google Scholar
  2. 2.
    B. Clasbrummel, G. Muhr, and G. Möllenhoff, “Pressure sensors for the monitoring of diseases in surgical care.” Minimally Invasive Therapy and Allied Technologies, vol. 13, no. 2, pp. 105–109, 2004.Google Scholar
  3. 3.
    M.O. Schurr, “Sensors in minimally invasive therapy—A technology coming of age.” Guest Editorial for Minimally Invasive Therapy & Allied Technologies, vol. 13, no. 2, pp. 67, 2004.Google Scholar
  4. 4.
    C. Hierold, B. Clasbrummel, D. Behrend, T. Scheiter, M. Steger, K. Oppermann, H. Kapels, E. Landgraf, D. Wenzel, and D. Etzrodt, “Low power integrated pressure sensor system for medical applications”, Sensors and Actuators A, vol. 73, pp. 58–67, 1999.CrossRefGoogle Scholar
  5. 5.
    E. Renard, “Implantable glucose sensors for diabetes monitoring.” Minimally Invasive Therapy and Allied Technologies, vol. 13, no. 2, pp. 78–86, 2004.Google Scholar
  6. 6.
    A. Caduff, A. Buschor, R. Dewarrat, T. Schrepfer, L. Nosek, T. Heise, C. Kapitza, and L. Heinemann, “Evaluation of a non-invasive, continuous glucose monitoring system in patients with diabetes: Results of a glucose clamp study with hypoglycemic and hyperglycemic excursions.” Diabetologia, vol. 46 (suppl. 2), A45, 121, 2003.Google Scholar
  7. 7.
    E. Renard, “Implantable closed-loop glucose sensing and insulin-delivery: The future for insulin-pump therapy.” Curr Opin Pharmacol, vol. 2, pp. 708–716, 2003.MathSciNetGoogle Scholar
  8. 8.
    U. Fischer, “Fundamentals of glucose sensors.” Diabet. Med., vol. 8, pp. 309–321, 1991.Google Scholar
  9. 9.
    W.K. Ward, L.B. Jansen, E. Anderson, G. Reach, J.C. Klein, and G.S. Wilson, “A new amperometric glucose microsensor: in vitro and short-term in vivo evaluation.” Biosensors and Bioelectronics, vol. 17, pp. 181–189, 2002.CrossRefGoogle Scholar
  10. 10.
    M.N. Ericson, M.A. Wilson, G.L. Coté, J.S. Baba, W. Xu, M. Bobrek, C.L. Britton, M.S. Hileman, M.R. Moore, M.S. Emery, and R. Lenarduzzi, “Implantable sensor for blood flow monitoring after transplant surgery.” Minimally Invasive Therapy and Allied Technologies, vol. 13, no. 2, pp. 87–94, 2004.Google Scholar
  11. 11.
    K. Abraham-Fuchs, W. Gumbrecht, C. Hierold, and A. Steckenborn, “Multiparameter sensor microsystems—from research towards a mass product?,” Sensor 97 International Congress, Nürnberg, pp. 13–15, 1997.Google Scholar
  12. 12.
    Q. Huang and M. Oberle, “A 0.5-mW passive telemetry IC for biomedical applications,” IEEE Journal of Solid-state Circuits, vol. 33, no. 7, pp. 937–946, 1998.CrossRefGoogle Scholar
  13. 13.
    S.K. Lau, K.N. Length, and K.T. Mok, “Analysis of low drop-out regulator topologies for low-voltage regulation.” IEEE Conference on Electron Devices and Solid-State Circuits, 2003, vols. 16–18, pp. 379–382, 2003.Google Scholar
  14. 14.
    R. Baker, H. Li, and D. Boyce, “CMOS: Circuit Design, Layout and Simulation”, Prentice Hall, 1997.Google Scholar
  15. 15.
    M. Filanovsky and H. Baltes, “CMOS Schmitt Trigger Design.” Circuits and Systems I: IEEE Transactions on Fundamental Theory and Applications, vol. 41, no. 1, pp. 46–49, 1994.Google Scholar

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Mohammad A. Adeeb
    • 1
  • Hung Nguyen
    • 1
  • Syed K. Islam
    • 1
  • Mo Zhang
    • 1
  1. 1.Department of Electrical and Computer EngineeringUniversity of TennesseeKnoxvilleUSA

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