Abstract
Mental health and substance use disorders can negatively affect physical health, illness management, care access, and quality of life. These behavioral health conditions are prevalent and undertreated among people with HIV and may worsen outcomes along the entire HIV Care Continuum. This narrative review of tested interventions for integrating care for HIV and behavioral health disorders summarizes and contextualizes findings from systematic reviews and meta-analyses conducted in the past decade. We sought to identify gaps in research that hinder implementing evidence-based integrated care approaches. Using terms from the Substance Abuse and Mental Health Services Administration-Health Resources & Services Administration standard framework for integrated health care, we searched PubMed and PsycInfo to identify peer-reviewed systematic reviews or meta-analyses of intervention studies to integrate behavioral health and HIV published between 2010 and 2020. Among 23 studies identified, only reviews and meta-analyses that described interventions from the United States designed to integrate BH services into HIV settings for adults were retained, leaving six studies for narrative review by the study team. Demonstrated benefits from the relatively small literature on integrated care interventions include improved patient- and service-level outcomes, particularly for in-person case management and outreach interventions. Needed are systems-level integration interventions with assessments of long-term outcomes on behavioral health symptoms, HIV viral suppression, HIV transmission rates, and mortality. HIV, primary care, and other providers must include behavioral health as a part of overall healthcare and must play a central role in behavioral health care delivery. Research is needed to guide their way.
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References
Goldman ML, Smal E, Richki T, Pincus HA, Chung H. Implementation of Behavioral Health Integration in small primary care settings: lessons learned and future directions. Commun Ment Health J. 2022;58:136–44. https://doi.org/10.1007/s10597-021-00802-z.
National Alliance on Mental Illness. Mental health by the numbers. 2020. https://www.nami.org/mhstats. Accessed 11 June 2021.
US Burden of Disease Collaborators. The state of US health, 1990–2010: burden of diseases, injuries, and risk factors. JAMA. 2013;310:591–608. https://doi.org/10.1001/jama.2013.13805.
Health, Resources & Services Administration. Health Professional Shortage Areas (HPSA) — Mental Health. 2022. bit.ly/38yCu60. Accessed 11 2022.
Green LA, Cifuentes M. Advancing care together by integrating primary care and behavioral health. J Am Board Fam Med. 2015;28(Suppl 1):S1–6. https://doi.org/10.3122/jabfm.2015.S1.150102.
Miller-Matero LR, Khan S, Thiem R, DeHondt T, Dubaybo H, Moore D. Integrated primary care: patient perceptions and the role of mental health stigma. Prim Health Care Res Dev. 2018;20:e48. https://doi.org/10.1017/S1463423618000403.
Nyblade L, Stockton MA, Giger K, Bond V, Ekstrand ML, McLean R, Mitchell EMH, Nelson LE, Sapag JC, Siraprapasiri T, Turan J, Wouters E. Stigma in health facilities: why it matters and how we can change it. BMC Med. 2019;17:25. https://doi.org/10.1186/s12916-019-1256-2.
Institute for Healthcare Improvement. 90-Day R&D project final summary report: Integrating behavioral health and primary care. Cambridge, MA: Institute for Healthcare Improvement. 2014. https://www.ihi.org/resources/Pages/Publications/BehavioralHealthIntegrationIHI90DayRDProject.aspx. Accessed 8 July 2019.
Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Young B, Peterson D, Rutter CM, McGregor M, McCulloch D. Collaborative care for patients with depression and chronic illnesses. N Engl J Med. 2010;363:2611–20. https://doi.org/10.1056/NEJMoa1003955.
Wang PS, Lane M, Olfson M, Pincus HA, Wells KB, Kessler RC. Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:629–40. https://doi.org/10.1001/archpsyc.62.6.629.
Leung LB, Rubenstein LV, Jaske E, Taylor L, Post EP, Nelson KM, Rosland A. Association of integrated mental health services with physical health quality among VA primary care patients. J Gen Intern Med. 2022;37:3331–7. https://doi.org/10.1007/s11606-021-07287-2.
Unützer J, Katon W, Callahan CM, Williams JW, Hunkeler E, Harpole L, Hoffing M, Della Penna RD, Noël PH, Lin EH, Areán PA, Hegel MT, Tang L, Belin TR, Oishi S, Langston C, IMPACT Investigators. Improving mood-promoting access to collaborative treatment: collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002;288:2836–45. https://doi.org/10.1001/jama.288.22.2836.
Liu NH, Daumit GL, Dua T, Aquila R, Charlson F, Cuijpers P, Druss B, Dudek K, Freeman M, Fujii C, Gaebel W, Hegerl U, Levav I, Munk Laursen T, Ma H, Maj M, Elena Medina-Mora M, Nordentoft M, Prabhakaran D, Pratt K, Prince M, Rangaswamy T, Shiers D, Susser E, Thornicroft G, Wahlbeck K, Fekadu WA, Whiteford H, Saxena S. Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry. 2017;16:30–40. https://doi.org/10.1002/wps.20384.
Walker ER, McGee RE, Druss BG. Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry. 2015;72:334–41. https://doi.org/10.1001/jamapsychiatry.2014.2502.
Katon W, Unutzer J, Wells K, Jones L. Collaborative depression care: history, evolution and ways to enhance dissemination and sustainability. Gen Hosp Psychiatry. 2010;32:456–64. https://doi.org/10.1016/j.genhosppsych.2010.04.001.
Heath B, Wise Romero P, Reynolds K. A Standard Framework for Levels of Integrated Healthcare. Washington, D.C. SAMHSA-HRSA Center for Integrated Health Solutions; 2013.
Krumme AA, Kaigamba F, Binagwaho A, Murray MB, Rich ML, Franke MF. Depression, adherence and attrition from care in HIV-infected adults receiving antiretroviral therapy. J Epidemiol Commun Health. 2014;69:284–9. https://doi.org/10.1136/jech-2014-204494.
Uthman OA, Magidson JF, Safren SA, Nachega JB. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Curr HIV/AIDS Rep. 2014;11:291–307. https://doi.org/10.1007/s11904-014-0220-1.
Lesko CR, Sampson LA, Miller WC, Clymore J, Leone PA, Swygard H, Powers KA. Measuring the HIV Care Continuum using public health surveillance data in the United States. J Acquir Immune Defic Syndrome. 2015;70:489–94. https://doi.org/10.1097/QAI.0000000000000788.
Remien RH, Stirratt MJ, Nguyen N, Robbins RN, Pala AN, Mellins CA. Mental health and HIV/AIDS: the need for an integrated response. AIDS. 2019;15:1411–20. https://doi.org/10.1097/QAD.0000000000002227.
Whetten K, Reif S, Ostermann J, Pence BW, Swartz M, Whetten R, Conover C, Bouis S, Thielman N, Eron J. Improving health outcomes among individuals with HIV, mental illness, and substance use disorders in the Southeast. AIDS Care. 2006;18(Suppl 1):S18–26. https://doi.org/10.1080/09540120600839330.
Bousman CA, Cherner M, Ake C, Letendre S, Atkinson JH, Patterson TL, Grant I, Everall IP, The HNRC Group. Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV. J Affect Disord. 2009;119:84–91. https://doi.org/10.1016/j.jad.2009.04.006.
Bradley MV, Remien RH, Dolezal C. Depression symptoms and sexual HIV risk behavior among serodiscordant couples. Psychosom Med. 2008;70:186–91. https://doi.org/10.1097/PSY.0b013e3181642a1c.
Gordillo V, del Amo J, Soriano V, González-Lahoz J. Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. AIDS. 1999;13:1763–9. https://doi.org/10.1097/00002030-199909100-00021.
Hart TA, James CA, Purcell DW, Farber E. Social anxiety and HIV transmission risk among HIV-seropositive male patients. AIDS Patient Care STDs. 2008;22:879–86. https://doi.org/10.1089/apc.2008.0085.
Mellins CA, Kang E, Leu C, Havens JF, Chesney MA. Longitudinal study of mental health and psychosocial predictors of medical treatment adherence in mothers living with HIV disease. AIDS Patient Care STDs. 2003;17:407–16. https://doi.org/10.1089/108729103322277420.
Mugavero M, Ostermann J, Whetten K, Leserman J, Swartz M, Stangl D, Thielman N. Barriers to antiretroviral adherence: the importance of depression, abuse, and other traumatic events. AIDS Patient Care STDs. 2006;20:418–28. https://doi.org/10.1089/apc.2006.20.418.
Rajabiun S, Mallinson RK, McCoy K, Coleman S, Drainoni M-L, Rebholz C, Holbert T. Getting me back on Track: the role of outreach interventions in engaging and retaining people living with HIV/AIDS in medical care. AIDS Patient Care STDs. 2007;21:S–20. https://doi.org/10.1089/apc.2007.9990. -29.
Ryan K, Forehand R, Solomon S, Miller C. Depressive symptoms as a link between barriers to care and sexual risk behavior of HIV-infected individuals living in non-urban areas. AIDS Care. 2008;20:331–6. https://doi.org/10.1080/09540120701660338.
Pence BW, Mills JC, Bengtson AM, Gaynes BN, Breger TL, Cook RL, Moore RD, Grelotti DJ, O’Cleirigh C, Mugavero MJ. Association of increased chronicity of depression with HIV appointment attendance, treatment failure, and mortality among HIV-infected adults in the United States. JAMA Psychiatry. 2018;75:379–85. https://doi.org/10.1001/jamapsychiatry.2017.4726.
Bowen D, Heald A, LePoire E, Jones A, Gadbois D, Russo J, Carruthers J. Population-based implementation of behavioral health detection and treatment into primary care: early data from New York state. BMC Health Serv Res. 2021;21:922. https://doi.org/10.1186/s12913-021-06892-5.
Woltmann E, Grogan-Kaylor A, Perron B, Georges H, Kilbourne AM, Bauer MS. Comparative effectiveness of collaborative chronic care models for mental health conditions across primary, specialty, and behavioral health care settings: systematic review and meta-analysis. Am J Psychiatry. 2012;169:790–804. https://doi.org/10.1176/appi.ajp.2012.11111616.
Baethe C, Goldbeck-Wood S, Mertens S. SANRA—A scale for the quality assessment of narrative review articles. Res Integr Peer Rev. 2019;4:5. https://doi.org/10.1186/s41073-019-0064-8.
Chuah F, Haldane VE, Cervero-Liceras F, Ong SE, Sigfrid LA, Murphy G, Watt N, Balabanova D, Hogarth S, Maimaris W, Otero L, Buse K, McKee M, Piot P, Perel P, Legido-Quigley H. Interventions and approaches to integrating HIV and mental health services: a systematic review. Health Policy Plann. 2017;32(suppl4):iv27–47. https://doi.org/10.1093/heapol/czw169.
Watt N, Sigfrid L, Legido-Quigley H, Hogarth S, Maimaris W, Otero-García L, Perel P, Buse K, McKee M, Piot P, Balabanova D. Health systems facilitators and barriers to the integration of HIV and chronic disease services: a systematic review. Health Policy Plann. 2017;32(suppl4):iv13–26. https://doi.org/10.1093/heapol/czw149.
Handford CD, Tynan A, Agha A, Rzeznikiewiz D, Glazier RH. Organization of care for persons with HIV-infection: a systematic review. AIDS Care. 2017;29:807–16. https://doi.org/10.1080/09540121.2016.1199846.
Haldane V, Cervero-Liceras F, Chuah FL, Ong SE, Murphy G, Sigfrid L, Watt N, Balabanova D, Hogarth S, Maimaris W, Buse K, Piot P, McKee M, Perel P, Legido-Quigley H. Integrating HIV and substance use services: a systematic review. J Int AIDS Soc. 2017;20:21585. https://doi.org/10.7448/IAS.20.1.21585.
Vold JH, Aas C, Leiva RA, Vickerman P, Chalabianloo F, Løberg EM, Johansson KA, Fadnes LT. Integrated care of severe infectious diseases to people with substance use disorders; a systematic review. BMC Infect Dis. 2019;19:306. https://doi.org/10.1186/s12879-019-3918-2.
Orkin AM, Rao S, Venugopal J, Kithulegoda N, Wegier P, Ritchie SD, VanderBurgh D, Martiniuk A, Salamanca-Buentello F, Upshur R. Conceptual framework for task shifting and task sharing: an international Delphi study. Hum Resour Health. 2021;19:61. https://doi.org/10.1186/s12960-021-00605-z.
Thielke S, Vannoy S, Unützer J. Integrating mental health and primary care. Prim Care. 2007;34:571–92. https://doi.org/10.1016/j.pop.2007.05.007.
Watson LC, Amick HR, Gaynes BN, Brownley KA, Thaker S, Viswanathan M, Jonas DE. Practice-based interventions addressing concomitant depression and chronic medical conditions in the primary care setting: a systematic review and meta-analysis. J Prim Care Community Health. 2013;4:294–306. https://doi.org/10.1177/2150131913484040.
Agency for Healthcare Research and Quality. List of priority conditions for research under Medicare Modernization Act released. Press Release, December 15. 2004. http://archive.ahrq.gov/news/press/pr2004/mmapr.htm. Accessed 12 December 2011.
Adams K, Corrigan JM, editors. Priority Areas for National Action: transforming Health Care Quality. Washington, DC: National Academies; 2003. https://doi.org/10.17226/10593.
Brady J, Ho K, Clancy CM, Commentary. State snapshots—a picture of unacceptable variation: are we destined to live with geography is destiny? Am J Med Qual. 2008;23:492–5. https://doi.org/10.1177/1062860608325192.
Shaver J. The state of telehealth before and after the COVID-19 pandemic. Prim Care. 2022;49:517–30. https://doi.org/10.1016/j.pop.2022.04.002.
Cournos F, McKinnon K, Wainberg M. Epidemiology and Prevalence of Psychiatric Disorders Associated with HIV/AIDS (Second Edition). In: Cohen MA, Gorman JA, editors. Comprehensive Textbook of AIDS Psychiatry: a paradigm for Integrated Care. New York: Oxford University Press; 2017. https://doi.org/10.1093/med/9780199392742.003.0003.
Acknowledgements
This work was supported by a center grant and an Ending the HIV Epidemic supplement to that grant from the National Institute of Mental Health (P30-MH43520), Principal Investigator: Robert H. Remien, PhD. The authors thank Marian LaForest, MPH, an informationist at Columbia University Irving Medical Center, August C. Long Health Sciences Library, 701 West 168th Street, New York, NY 10032 USA, for developing and conducting the literature search.
Funding
This work was supported by a center grant and Ending the HIV Epidemic supplement to that grant from NIMH (P30-MH43520), Principal Investigator: Robert H. Remien, PhD. McKinnon, Boccher-Lattimore, and Cournos had the idea for this review article; McKinnon, Lentz, Boccher-Lattimore, Cournos, Pather, Sukumaran, Remien, and Mellins drafted and/or critically revised the work.
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This narrative review of systematic reviews and meta-analyses published in the peer-reviewed literature between 2010 and 2020 did not involve the participation of human subjects; as such, no ethical approval was required.
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McKinnon, K., Lentz, C., Boccher-Lattimore, D. et al. Interventions for Integrating Behavioral Health into HIV Settings for US Adults: A Narrative Review of Systematic Reviews and Meta-analyses, 2010–2020. AIDS Behav (2024). https://doi.org/10.1007/s10461-024-04324-z
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DOI: https://doi.org/10.1007/s10461-024-04324-z