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Prescription Opioid Misuse, Pain Interference, Resilience, and Anxiety Among Chinese People Living with HIV: A Moderated Mediation Model

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Abstract

Prescription opioid misuse (POM) is a concern in people living with HIV (PLWH). Pain interference is a robust factor, and its influences would occur through anxiety and resilience. Limited POM studies attend to Chinese PLWH. This study examined POM and its underlying psychological mechanism using data of PLWH with pain (n = 116) from a cohort study in Guangxi. The PROCESS macro was employed to examine a hypothesized moderated mediation model among pain interference, resilience, anxiety, and POM. Results showed 10.3% PLWH engaged in past-three-month POM. After controlling for demographics, HIV-related clinical outcomes, and pain severity, anxiety mediated the association between pain interference and POM (β = 0.46, 95% CI = 0.01 to 10.49), and the mediation was moderated by resilience (moderated mediation index = − 0.02, 95% CI = − 0.784 to − 0.001). Chinese PLWH seem to misuse opioids to cope with pain-related anxiety. Resilience appears to offer protection.

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Data Availability

Data can be obtained by contacting Dr. Xiaoming Li at xiaoming@mailbox.sc.edu.

Code Availability

Codes can be obtained by contacting Dr. Cheuk Chi Tam at ctam@mailbox.sc.edu.

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Funding

Research reported in this manuscript was supported in part by the National Institute of Mental Health of the National Institutes of Health under Award Number NIH R01MH0112376. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, South Carolina SmartState Center for Healthcare Quality, University of South Carolina, Discovery I, Suite 413, 915 Greene Street, 29208, Columbia, SC, USA

    Cheuk Chi Tam & Xiaoming Li

  2. Department of Psychology, Virginia Commonwealth University, 23284, Richmond, VA, PO Box 842018, USA

    Eric G. Benotsch

  3. Guangxi Zhuang Autonomous Region Center for Diseases Control and Prevention, Nanning, China

    Yuejiao Zhou & Zhiyong Shen

Authors
  1. Cheuk Chi Tam
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  2. Eric G. Benotsch
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  3. Xiaoming Li
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Correspondence to Cheuk Chi Tam.

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The authors have no conflicts of interest to report.

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The study protocol was approved by the Institutional Review Boards of both University of South Carolina in the United States and Guangxi Center of Disease Prevention and Control in China.

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Informed consent was obtained from all participants prior to their participation in the study.

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Tam, C.C., Benotsch, E.G., Li, X. et al. Prescription Opioid Misuse, Pain Interference, Resilience, and Anxiety Among Chinese People Living with HIV: A Moderated Mediation Model. AIDS Behav 27, 3508–3514 (2023). https://doi.org/10.1007/s10461-023-04066-4

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  • DOI: https://doi.org/10.1007/s10461-023-04066-4

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