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Preferences for Current and Future PrEP Modalities Among PrEP-Experienced Gay and Bisexual Men in Australia

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Alternatives to daily dosing of HIV pre-exposure prophylaxis (PrEP) are continuing to emerge. From October 2019 to March 2020, we conducted an online survey of PrEP-experienced gay and bisexual men in Australia about interest in and preference for four different PrEP modalities: daily dosing, event-driven dosing, long-acting injectable (LAI)-PrEP and subdermal PrEP implants. Using data from 1477 participants, we measured interest and preference of different modalities using multivariate logistic regression. High proportions of participants were interested in LAI-PrEP (59.7%), daily PrEP (52.0%), PrEP implants (45.3%) and event-driven PrEP (42.8%). LAI-PrEP was the most frequently selected preference (30.5%), followed by PrEP implants (26.3%), daily PrEP (21.4%) and event-driven PrEP (21.2%). Higher interest and preference for non-daily PrEP modalities were associated with being concerned about side effects and perceived difficulties with daily adherence. As novel modalities emerge, attitudes to them should be considered in public health messaging to facilitate informed decision-making.

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The authors would like to thank all the participants of the study and the collaborating organisations ACON and the Centre for Social Research in Health (CSRH). The PrEP in NSW Transition Study was supported by Funds from the NSW Ministry of Health.

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Authors and Affiliations



SV, BB, AG, IZ-M, MH and GP contributed to the study conception, study design and survey instrument development. Data collection was managed by SV. Data preparation and analysis were performed by CC and DF. The first draft of the manuscript was written by CC and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Curtis Chan.

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The authors have no conflicts of interest to declare that are relevant to the content of this article.

Ethical Approval

The questionnaire and methodology for this study was approved by the Human Research Ethics Committee of the University of New South Wales (Ethics Approval Number HC180411).

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Informed consent was obtained from all individual participants included in the study.

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Chan, C., Vaccher, S., Fraser, D. et al. Preferences for Current and Future PrEP Modalities Among PrEP-Experienced Gay and Bisexual Men in Australia. AIDS Behav 26, 88–95 (2022).

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