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Predictors of Event-Driven Regimen Choice in Current PrEP Users and Sexual Behavior Characteristics of MSM Receiving Sexual Health Services in New York City

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While daily PrEP is undeniably effective, broad-based adoption remains low. Non-daily PrEP modalities, like event-driven PrEP (ED PrEP), offer an efficient way to deliver PrEP’s protection to priority populations. We carried out an at-home survey with patients receiving sexual health services in a LGBTQ-clinic in New York (n = 147). Participants answered questions on ED PrEP awareness and preferences, sexual behavior, and sexual preparatory practices. Only 50% of our sample were aware of ED PrEP, about 30% met eligibility for ED PrEP, and 35% chose ED PrEP as a good HIV prevention option for them. In a robust Poisson model (n = 128), endorsement of ED PrEP as a good prevention choice was significantly more common in participants who were uninsured, preferred taking PrEP only when needed, and those who had concerns about side-effects. Furthermore, participants reported many sexual behaviors patterns and preparatory practices compatible with use of ED PrEP.


Si bien la PrEP diaria es innegablemente efectiva, la adopción generalizada sigue siendo baja. Las modalidades de PrEP no diarias, como la PrEP impulsada por eventos (ED PrEP), ofrecen una manera eficiente de brindar protección de PrEP a las poblaciones prioritarias. Realizamos una encuesta a domicilio con pacientes que recibían servicios de salud sexual en una clínica LGBTQ en Nueva York (n = 147). Los participantes respondieron preguntas sobre su conocimiento y sus preferencias de la ED PrEP, su comportamiento sexual, y sus prácticas de preparación sexual. Solo el 50% de nuestra muestra conocía la ED PrEP, alrededor del 30% cumplía con los requisitos para la ED PrEP, y el 35% eligió ED PrEP como una buena opción de prevención del HIV para ellos. En un modelo robusto de Poisson (n = 128), la aprobación de la ED PrEP como una buena opción de prevención fue significativamente más común en los participantes que no tenían seguro, preferían tomar la PrEP solo cuando era necesario, y aquellos que tenían preocupaciones sobre los efectos secundarios. Además, los participantes informaron muchos patrones de comportamiento sexual y prácticas preparatorias compatibles con el uso de ED PrEP.

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Special thanks to all the staff working at the sexual health clinic at Callen-Lorde Community Health Center. A special thanks to Esther Blanchard, Lara Comstock, Asa Radix, and Carlos Gomar.


This research was supported by R01MH106380 (Golub, PI).

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Correspondence to Pedro B. Carneiro.

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Informed consent was obtained from all individual participants included in the study. All procedures for this study were reviewed by the CUNY Integrated Institutional Review Board.

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Carneiro, P.B., Rincon, C. & Golub, S. Predictors of Event-Driven Regimen Choice in Current PrEP Users and Sexual Behavior Characteristics of MSM Receiving Sexual Health Services in New York City. AIDS Behav 25, 2410–2418 (2021).

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