Abstract
For persons diagnosed with HIV and who are coinfected with hepatitis C virus (HCV), chronic liver disease is a leading cause of death and excessive consumption of alcohol can be a contributing factor. Little is known about the factors these individuals identify as key to achieving sustained sobriety. In this qualitative study, fourteen HIV/HCV coinfected persons who endorsed past problematic drinking were interviewed about their path to sustained sobriety. In open-ended interviews, participants often described their drinking in the context of polysubstance use and their decision to become sober as a singular response to a transcendent moment or a traumatic event. All articulated specific, concrete strategies for maintaining sobriety. The perceived effect of the HIV or HCV diagnosis on sobriety was inconsistent, and medical care as an influence on sobriety was rarely mentioned. Qualitative interviews may offer new insights on interventions and support strategies for heavy-drinking persons with HIV/HCV coinfection.
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References
Centers for Disease Control. HIV and Viral Hepatitis: Fast Facts 2017 [Internet]. https://www.cdc.gov/hiv/pdf/library/factsheets/hiv-viral-hepatitis.pdf
Salmon-Ceron D, Lewden C, Morlat P, Bévilacqua S, Jougla E, Bonnet F, et al. Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol. J Hepatol. 2005;42(6):799–805.
Alavi M, Janjua NZ, Chong M, Grebely J, Aspinall EJ, Innes H, et al. The contribution of alcohol use disorder to decompensated cirrhosis among people with hepatitis C: an international study. J Hepatol. 2018;68(3):393–401.
Bonacini M. Alcohol use among patients with HIV infection. Ann Hepatol. 2011;10(4):502–7.
Cook RL, Zhu F, Belnap BH, Weber K, Cook JA, Vlahov D, et al. Longitudinal trends in hazardous alcohol consumption among women with human immunodeficiency virus infection, 1995–2006. Am J Epidemiol. 2009;169(8):1025–32.
Conigliaro J, Justice AC, Gordon AJ, Bryant K. Role of alcohol in determining human immunodeficiency virus (HIV)-relevant outcomes: A conceptual model to guide the implementation of evidence-based interventions into practice. Med Care. 2006;44(8 Suppl 2):S1-6.
Kim HN, Crane HM, Rodriguez CV, Van Rompaey S, Mayer KH, Christopoulos K, et al. The role of current and historical alcohol use in hepatic fibrosis among HIV-infected individuals. AIDS Behav. 2017;21(7):1878–84.
Lucas GM. Substance abuse, adherence with antiretroviral therapy, and clinical outcomes among HIV-infected individuals. Life Sci. 2011;88(21):948–52.
Azar MM, Springer SA, Meyer JP, Altice FL. A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend. 2010;112(3):178–93.
Monroe AK, Lau B, Mugavero MJ, Mathews WC, Mayer KH, Napravnik S, et al. Heavy alcohol use is associated with worse retention in HIV care. J Acquir Immune Defic Syndr 1999. 2016;73(4):419–25.
O’Leary MC, Hutchinson SJ, Allen E, Palmateer N, Cameron S, Taylor A, et al. The association between alcohol use and hepatitis C status among injecting drug users in Glasgow. Drug Alcohol Depend. 2012;123(1):180–9.
Crane HM, Nance R, Merrill JO, Hutton H, Chander G, McCaul ME, et al. Not all non-drinkers with HIV are equal: demographic and clinical comparisons among current non-drinkers with and without a history of prior alcohol use disorders. AIDS Care. 2017;29(2):177–84.
Weiss L, Gass J, Egan JE, Ompad DC, Trezza C, Vlahov D. Understanding prolonged cessation from heroin use: findings from a community-based sample. J Psychoactive Drugs. 2014;46(2):123–32.
Mackinnon N, Bhatia U, Nadkarni A. The onset and progression of alcohol use disorders: a qualitative study from Goa, India. J Ethn Subst Abuse. 2017;18(1):89–102.
Venner KL, Hagler K, Cloud V, Greenfield B. Native Americans resolve alcohol use disorder: “Whatever it takes or all that it takes.” Cultur Divers Ethnic Minor Psychol. 2019;25(3):350–8.
Hayaki J, Anderson BJ, Herman DS, Moitra E, Pinkston MM, Kim HN, et al. Motivation to quit drinking in individuals coinfected with HIV and hepatitis C. AIDS Behav. 2020;24(6):1709–16.
Best DW, Ghufran S, Day E, Ray R, Loaring J. Breaking the habit: a retrospective analysis of desistance factors among formerly problematic heroin users. Drug Alcohol Rev. 2008;27(6):619–24.
Orford PJ, Kerr C, Copello A, Hodgson R, Alwyn T, Black R, et al. Why people enter treatment for alcohol problems: findings from UK Alcohol Treatment Trial pre-treatment interviews. J Subst Use. 2006;11(3):161–76.
Von Unger H, Collins PY. Transforming the meaning of HIV/AIDS in recovery from substance use: a aualitative study of HIV-positive women in New York. Health Care Women Int. 2005;26(4):308–24.
Moitra E, Anderson BJ, Herman DS, Hayaki J, Pinkston MM, Kim HN, et al. Examination of using alcohol to cope, depressive symptoms, and perceived social support in persons with HIV and hepatitis C. AIDS Care. 2020;25:1–8.
Drake RE, O’Neal EL, Wallach MA. A systematic review of psychosocial research on psychosocial interventions for people with co-occurring severe mental and substance use disorders. J Subst Abuse Treat. 2008;34(1):123–38.
Cleary M, Hunt GE, Matheson SL, Siegfried N, Walter G. Psychosocial interventions for people with both severe mental illness and substance misuse. Cochrane Database Syst Rev. 2008. https://doi.org/10.1002/14651858.CD001088.pub2/abstract.
Wang K, Burton CL, Pachankis JE. Depression and substance use: towards the development of an emotion regulation model of stigma coping. Subst Use Misuse. 2018;53(5):859–66.
Sullivan LE, Goulet JL, Justice AC, Fiellin DA. Alcohol consumption and depressive symptoms over time: a longitudinal study of patients with and without HIV infection. Drug Alcohol Depend. 2012;117(2–3):158–63.
Lee SB, Chung S, Lee H, Seo JS. The mutual relationship between men’s drinking and depression: a 4-year longitudinal analysis. Alcohol Alcohol. 2018;53(5):597–602.
Holahan CJ, Moos RH, Holahan CK, Cronkite RC, Randall PK. Drinking to cope and alcohol use and abuse in unipolar depression: a 10-year model. J Abnorm Psychol. 2003;112(1):159–65.
Fletcher JB, Reback CJ. Mental health disorders among homeless, substance-dependent men who have sex with men. Drug Alcohol Rev. 2017;36(4):555–9.
Green CA, Yarborough MT, Polen MR, Janoff SL, Yarborough BJH. Dual recovery among people with serious mental illnesses and substance problems: a qualitative analysis. J Dual Diagn. 2015;11(1):33–41.
Smelson DA, Kline A, Kuhn J, et al. A wraparound treatment engagement intervention for homeless veterans with co-occurring disorders. Psychol Serv. 2013;10(2):161–7.
Aceijas C, Rhodes T. Global estimates of prevalence of HCV infection among injecting drug users. Int J Drug Policy. 2007;18(5):352–8.
Kim HN, Howell A, Blevins CE, Pinkston MM, Herman DS, Stein MD. Perceptions of alcohol risk among HIV/hepatitis C coinfected patients. J Addict Med. 2019 https://journals.lww.com/journaladdictionmedicine/Abstract/publishahead/Perceptions_of_Alcohol_Risk_Among_HIV_Hepatitis_C.99317.aspx#pdf-link
Guest G, Bunce A, Johnson L. How many interviews are enough? An experiment with data saturation and variability. Field Methods. 2006;18(1):59–82.
Francis JJ, Johnston M, Robertson C, Glidewell L, Entwistle V, Eccles MP, et al. What is an adequate sample size? Operationalising data saturation for theory-based interview studies. Psychol Health. 2010;25(10):1229–45.
Wildemuth BM. Applications of Social Research Methods to Questions in Information and Library Science, 2nd Edition. ABC-CLIO; 2016. 445 p.
Zhang Y, Wildemuth BM. Unstructured Interviews. In: Applications of Social Research Methods to Questions in Information and Library Science.
Strauss A, Corbin JM. Grounded Theory in Practice. SAGE, London; 1997. 296 p.
Dedoose 8.0.32, web application for managing, analyzing, and presenting qualitative and mixed method research data. Los Angeles, CA: SocioCultural Research Consulants; 2018.
Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3(2):77–101.
Dennis M, Scott CK. Managing addiction as a chronic condition. Addict Sci Clin Pract. 2007;4(1):45–55.
Matthews S, Dwyer R, Snoek A. Stigma and self-stigma in addiction. J Bioethical Inq. 2017;14(2):275–86.
Luoma JB, Kohlenberg BS, Hayes SC, Bunting K, Rye AK. Reducing self-stigma in substance abuse through acceptance and commitment therapy: model, manual development, and pilot outcomes. Addict Res Theory. 2008;16(2):149–65.
Paquette CE, Pollini RA. Injection drug use, HIV/HCV, and related services in nonurban areas of the United States: a systematic review. Drug Alcohol Depend. 2018;1(188):239–50.
Csete J, Kamarulzaman A, Kazatchkine M, Altice F, Balicki M, Buxton J, et al. Public health and international drug policy. Lancet Lond Engl. 2016;387(10026):1427–80.
Altice FL, Kamarulzaman A, Soriano VV, Schechter M, Friedland GH. Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs. Lancet Lond Engl. 2010;376(9738):367–87.
Hedden SL, Martins SS, Malcolm RJ, Floyd L, Cavanaugh CE, Latimer WW. Patterns of illegal drug use among an adult alcohol dependent population: results from the National Survey on Drug Use and Health. Drug Alcohol Depend. 2010;106(2–3):119.
Timko C, Han X, Woodhead E, Shelley A, Cucciare MA. Polysubstance use by stimulant users: health outcomes over three years. J Stud Alcohol Drugs. 2018;79(5):799–807.
Walsh DC, Hingson RW, Merrigan DM, et al. The impact of a physician’s warning on recovery after alcoholism treatment. JAMA. 1992;267(5):663–7.
Friedmann PD, Zhang Z, Hendrickson J, Stein MD, Gerstein DR. Effect of primary medical care on addiction and medical severity in substance abuse treatment programs. J Gen Intern Med. 2003;18(1):1–8.
Stein MD, Herman DS, Kim HN, et al. A randomized trial comparing brief advice and motivational interviewing for persons with HIV-HCV co-infection who drink alcohol. AIDS Behav. In press.
Jakobsson A, Hensing G, Spak F. Developing a willingness to change: treatment-seeking processes for people with alcohol problems. Alcohol Alcohol. 2005;40(2):118–23.
Stokes M, Schultz P, Alpaslan A. Narrating the journey of sustained recovery from substance use disorder. Subst Abuse Treat Prev Policy. 2018;13(1):35.
Luciano A, Bryan EL, Carpenter-Song EA, Woods M, Armstrong K, Drake RE. Long-term sobriety strategies for men with co-occurring disorders. J Dual Diagn. 2014;10(4):212–9.
Greenfield SF, Brooks AJ, Gordon SM, Green CA, Kropp F, McHugh RK, et al. Substance abuse treatment entry, retention, and outcome in women: a review of the literature. Drug Alcohol Depend. 2007;86(1):1–21.
McHugh RK, Votaw VR, Sugarman DE, Greenfield SF. Sex and gender differences in substance use disorders. Clin Psychol Rev. 2018;1(66):12–23.
Frajzyngier V, Neaigus A, Gyarmathy VA, Miller M, Friedman SR. Gender differences in injection risk behaviors at the first injection episode. Drug Alcohol Depend. 2007;89(2–3):145–52.
Hser YI, Anglin MD, Booth MW. Sex differences in addict careers. 3. Addiction. Am J Drug Alcohol Abuse. 1987;13(3):231–51.
Hutton HE, Cardin N, Ereme K, Chander G, Xu X, McCaul ME. Psychiatric disorders and substance use among African American women in HIV care. AIDS Behav. 2020;24:10.
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Funding for this study was provided by NIAAA Grant R01 AA023726 awarded to Dr. Stein.
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AH and AL contributed equally to this work as lead authors.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (University of Washington Institutional Review Board) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Howell, A., Lambert, A., Pinkston, M.M. et al. Sustained Sobriety: A Qualitative Study of Persons with HIV and Chronic Hepatitis C Coinfection and a History of Problematic Drinking. AIDS Behav 25, 1083–1093 (2021). https://doi.org/10.1007/s10461-020-03067-x
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DOI: https://doi.org/10.1007/s10461-020-03067-x
Keywords
- HIV
- Chronic hepatitis C
- Alcohol
- Sobriety
- Qualitative interview