Haubrich RH, Little SJ, Currier JS, Forthal DN, Kemper CA, Beall GN, et al. The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. AIDS. 1999;13(9):1099–107.
Castillo-Mancilla JR, Brown TT, Erlandson KM, Palella FJ, Gardner EM, Macatangay BJC, et al. Suboptimal adherence to combination antiretroviral therapy is associated with higher levels of inflammation despite HIV suppression. Clin Infect Dis. 2016;63(12):1661–7.
Walson JL, Brown ER, Otieno PA, Mbori-Ngacha DA, Wariua G, Obimbo EM, et al. Morbidity among HIV-1-infected mothers in Kenya: prevalence and correlates of illness during 2-year postpartum follow-up. JAIDS J Acquir Immune Defic Syndr. 2007;46(2):208–15.
Uy J, Armon C, Buchacz K, Wood K, Brooks JT. Initiation of HAART at higher CD4 cell counts is associated with a lower frequency of antiretroviral drug resistance mutations at virologic failure. JAIDS J Acquir Immune Defic Syndr. 2009;51(4):450–3.
Vella S, Schwartländer B, Sow SP, Eholie SP, Murphy RL. The history of antiretroviral therapy and of its implementation in resource-limited areas of the world. AIDS. 2012;26(10):1231–41.
Nachega JB, Uthman OA, Anderson J, Peltzer K, Wampold S, Cotton MF, et al. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS. 2012;26(16):2039–52.
Onoya D, Sineke T, Brennan AT, Long L, Fox MP. Timing of pregnancy, postpartum risk of virologic failure and loss to follow-up among HIV-positive women. AIDS. 2017;31(11):1593–602.
UNAIDS. On the Fast-Track to an AIDS-Free Generation. 2016. https://www.unaids.org/sites/default/files/media_asset/GlobalPlan2016_en.pdf.
Hodgson I, Plummer ML, Konopka SN, Colvin CJ, Jonas E, Albertini J, et al. A systematic review of individual and contextual factors affecting ART initiation, adherence, and retention for HIV-infected pregnant and postpartum women. PLoS ONE. 2014;9(11):e111421.
Colvin CJ, Konopka S, Chalker JC, Jonas E, Albertini J, Amzel A, et al. A systematic review of health system barriers and enablers for antiretroviral therapy (ART) for HIV-infected pregnant and postpartum women. PLoS ONE. 2014;9(10):e108150.
Gill MM, Umutoni A, Hoffman HJ, Ndatimana D, Ndayisaba GF, Kibitenga S, et al. Understanding antiretroviral treatment adherence among HIV-positive women at four postpartum time intervals: qualitative results from the Kabeho study in Rwanda. AIDS Patient Care STDs. 2017;31(4):153–66.
Vitalis D. Factors affecting antiretroviral therapy adherence among HIV-positive pregnant and postpartum women: an adapted systematic review. Int J STD AIDS. 2013;24:427–32.
Vitalis D, Hill Z. Antiretroviral adherence perspectives of pregnant and postpartum women in Guyana: barriers and facilitators. J Int Assoc Provid AIDS Care JIAPAC. 2017;16(2):180–8.
Mellins CA, Chu C, Malee K, Allison S, Smith R, Harris L, et al. Adherence to antiretroviral treatment among pregnant and postpartum HIV-infected women. AIDS Care. 2008;20(8):958–68.
Iyun V, Brittain K, Phillips TK, le Roux S, McIntyre JA, Zerbe A, et al. Prevalence and determinants of unplanned pregnancy in HIV-positive and HIV-negative pregnant women in Cape Town, South Africa: a cross-sectional study. BMJ Open. 2018;8(4):e019979.
Carballo E, et al. Assessing relationships between health-related quality of life and adherence to antiretroviral therapy. Qual Life Res. 2004;13:587–99.
Mannheimer SB, Matts J, Telzak E, Chesney M, Child C, Wu AW, et al. Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence. AIDS Care. 2005;17(1):10–22.
Vagiri RV, Meyer JC, Gous AGS. Health-related quality of life and adherence to antiretroviral treatment over a 12-month period for patients attending two public sector clinics in South Africa. Afr J Phys Health Educ Recreat Dance. 2015;Suppl 2:228–40.
Whetten K, Shirey K, Pence BW, Yao J, Thielman N, Whetten R, et al. Trauma history and depression predict incomplete adherence to antiretroviral therapies in a low income country. PLoS ONE. 2013;8(10):e74771.
Usitalo A, Leister E, Tassiopoulos K, Allison S, Malee K, Paul ME, et al. Relationship between viral load and self-report measures of medication adherence among youth with perinatal HIV infection. AIDS Care. 2014;26(1):107–15.
Bottonari KA, Safren SA, McQuaid JR, Hsiao C-B, Roberts JE. A longitudinal investigation of the impact of life stress on HIV treatment adherence. J Behav Med. 2010;33(6):486–95.
Turan B, Smith W, Cohen MH, Wilson TE, Adimora AA, Merenstein D, et al. Mechanisms for the negative effects of internalized HIV-related stigma on antiretroviral therapy adherence in women: the mediating roles of social isolation and depression. J Acquir Immune Defic Syndr. 2016;72(2):198–205.
Nagata JM, Magarenge R, Young SL, Oguta J, Weiser SA, Cohen CR. Social determinants, lived experiences, and consequences of household food insecurity among persons living with HIV/AIDS on the shore of Lake Victoria, Kenya. AIDS Care. 2012;24(6):728–36.
Singer AW, Weiser SD, McCoy SI. Does food insecurity undermine adherence to antiretroviral therapy? A Systematic Review. AIDS Behav. 2015;19(8):1510–26.
McMahon JH, Wanke CA, Elliott JH, Skinner S, Tang AM. Repeated assessments of food security predict CD4 change in the setting of antiretroviral therapy. JAIDS J Acquir Immune Defic Syndr. 2011;58(1):60–3.
Hong SY, Fanelli TJ, Jonas A, Gweshe J, Tjituka F, Sheehan HMB, et al. Household food insecurity associated with antiretroviral therapy adherence among HIV-infected patients in Windhoek, Namibia. JAIDS J Acquir Immune Defic Syndr. 2014;67(4):e115–e12222.
Kalichman SC, Grebler T, Amaral CM, McKerney M, White D, Kalichman MO, et al. Food insecurity and antiretroviral adherence among HIV positive adults who drink alcohol. J Behav Med. 2014;37(5):1009–188.
Chop E, Duggaraju A, Malley A, Burke V, Caldas S, Yeh PT, et al. Food insecurity, sexual risk behavior, and adherence to antiretroviral therapy among women living with HIV: a systematic review. Health Care Women Int. 2017;38(9):927–44.
Young S, Wheeler AC, McCoy SI, Weiser SD. A review of the role of food insecurity in adherence to care and treatment among adult and pediatric populations living with HIV and AIDS. AIDS Behav. 2014;18(S5):505–15.
Aibibula W, Cox J, Hamelin A-M, Mamiya H, Klein MB, Brassard P. Food insecurity and low CD4 count among HIV-infected people: a systematic review and meta-analysis. AIDS Care. 2016;28(12):1577–85.
Leddy AM, Sheira LA, Tamraz B, Sykes C, Kashuba ADM, Wilson TE, et al. Food insecurity is associated with lower levels of antiretroviral drug concentrations in hair among a cohort of women living with HIV in the United States. Clin Infect Dis. 2019. https://doi.org/10.1093/cid/ciz1007.
Weiser SD, Tuller DM, Frongillo EA, Senkungu J, Mukiibi N, Bangsberg DR. Food insecurity as a barrier to sustained antiretroviral therapy adherence in Uganda. PLoS ONE. 2010;5(4):e10340.
Tsai AC, Bangsberg DR, Frongillo EA, Hunt PW, Muzoora C, Martin JN, et al. Food insecurity, depression and the modifying role of social support among people living with HIV/AIDS in rural Uganda. Soc Sci Med. 2012;74(12):2012–9.
Vyavaharkar M, Moneyham L, Tavakoli A, Phillips KD, Murdaugh C, Jackson K, et al. Social support, coping, and medication adherence among HIV-positive women with depression living in rural areas of the southeastern United States. AIDS Patient Care STDs. 2007;21(9):667–80.
Kelly JD, Hartman C, Graham J, Kallen MA, Giordano TP. Social support as a predictor of early diagnosis, linkage, retention, and adherence to HIV care: results from the steps study. J Assoc Nurses AIDS Care. 2014;25(5):405–13.
Kabore L, Muntner P, Chamot E, Zinski A, Burkholder G, Mugavero MJ. Self-report measures in the assessment of antiretroviral medication adherence: comparison with medication possession ratio and HIV viral load. J Int Assoc Provid AIDS Care JIAPAC. 2015;14(2):156–62.
Berg KM, Arnsten JH. Practical and conceptual challenges in measuring antiretroviral adherence. JAIDS. 2006;43(Supplement 1):S79–87.
Alcaide ML, Ramlagan S, Rodriguez VJ, Cook R, Peltzer K, Weiss SM, et al. Self-report and dry blood spot measurement of antiretroviral medications as markers of adherence in pregnant women in Rural South Africa. AIDS Behav. 2017;21(7):2135–40.
Baxi SM, Greenblatt RM, Bacchetti P, Jin C, French AL, Keller MJ, et al. Nevirapine concentration in hair samples is a strong predictor of virologic suppression in a prospective cohort of HIV-infected patients. PLoS ONE. 2015;10(6):e0129100.
Gandhi M, Ameli N, Bacchetti P, Anastos K, Gange SJ, Minkoff H, et al. Atazanavir concentration in hair is the strongest predictor of outcomes on antiretroviral therapy. Clin Infect Dis Off Publ Infect Dis Soc Am. 2011;52(10):1267–75.
Gandhi M, Ameli N, Bacchetti P, Gange SJ, Anastos K, Levine A, et al. Protease inhibitor levels in hair strongly predict virologic response to treatment. AIDS. 2009;23(4):471–8.
Koss CA, Natureeba P, Mwesigwa J, Cohan D, Nzarubara B, Bacchetti P, et al. Hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan Women. AIDS Lond Engl. 2015;29(7):825–30.
Pintye J, Bacchetti P, Teeraananchai S, Kerr S, Prasitsuebsai W, Singtoroj T, et al. Brief report: lopinavir hair concentrations are the strongest predictor of viremia in HIV-infected Asian children and adolescents on second-line antiretroviral therapy. JAIDS J Acquir Immune Defic Syndr. 2017;76(4):367–71.
Prasitsuebsai W, Kerr SJ, Truong KH, Ananworanich J, Do VC, Nguyen LV, et al. Using lopinavir concentrations in hair samples to assess treatment outcomes on second-line regimens among Asian children. AIDS Res Hum Retroviruses. 2015;31(10):1009–144.
Tabb ZJ, Mmbaga BT, Gandhi M, Louie A, Kuncze K, Okochi H, et al. Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania. AIDS. 2018;32(9):1115–23.
van Zyl GU, van Mens TE, McIlleron H, Zeier M, Nachega JB, Decloedt E, et al. Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting. JAIDS. 2011;56(4):333–9.
Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, et al. Comparison of measures of adherence to human immunodeficiency virus preexposure prophylaxis among adolescent and young men who have sex with men in the United States. Clin Infect Dis. 2018;66(2):213–9.
Hickey MD, Salmen CR, Tessler RA, Omollo D, Bacchetti P, Magerenge R, et al. Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya. J Acquir Immune Defic Syndr. 1999;66(3):311–5.
Wu G, Zaman MH. Low-cost tools for diagnosing and monitoring HIV infection in low-resource settings. Bull World Health Organ. 2012;90(12):914–20.
Murnane PM, Bacchetti P, Currier JS, Brummel S, Okochi H, Phung N, et al. Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. AIDS. 2019;33:1657–62.
Gandhi M, Devi S, Bacchetti P, Chandy S, Heylen E, Phung N, et al. Measuring adherence to antiretroviral therapy via hair concentrations in India. JAIDS J Acquir Immune Defic Syndr. 2019;81(2):202–6.
Natamba BK, Kilama H, Arbach A, Achan J, Griffiths JK, Young SL. Reliability and validity of an individually focused food insecurity access scale for assessing inadequate access to food among pregnant Ugandan women of mixed HIV status. Public Health Nutr. 2015;18(16):2895–905.
Ndege S, Washington S, Kaaria A, Prudhomme-OMeara W, Were E, Nyambura M, et al. HIV prevalence and antenatal care attendance among pregnant women in a large home-based HIV counseling and testing program in Western Kenya. PLoS ONE. 2016;11(1):e0144618.
Kenya Demographic and Health Survey 2014. Nairobi, Kenya: Kenya National Bureau of Statistics, Kenya MOH, National AIDS Control Council, Kenya Medical Research Institute KEMRI, National Council for Population and Development, ICF International; 2015.
Kenya AIDS Response Progress Report. Nairobi. Kenya: National AIDS Control Council, Kenya Ministry of Health; 2018. p. 2018.
DiFrancesco R, Tooley K, Rosenkranz SL, Siminski S, Taylor CR, Pande P, et al. Clinical pharmacology quality assurance for HIV and related infectious diseases research. Clin Pharmacol Ther. 2013;93(6):479–82.
Antelman G, Smith Fawzi MC, Kaaya S, Mbwambo J, Msamanga GI, Hunter DJ, et al. Predictors of HIV-1 serostatus disclosure: a prospective study among HIV-infected pregnant women in Dar es Salaam Tanzania. AIDS. 2001;15(14):1865–74.
Ware NC, Idoko J, Kaaya S, Biraro IA, Wyatt MA, Agbaji O, et al. Explaining adherence success in Sub-Saharan Africa: an ethnographic study. PLoS Med. 2009;6(1):e1000011.
Natamba BK, Achan J, Arbach A, Oyok TO, Ghosh S, Mehta S, et al. Reliability and validity of the center for epidemiologic studies-depression scale in screening for depression among HIV-infected and -uninfected pregnant women attending antenatal services in northern Uganda: a cross-sectional study. BMC Psychiatry [Internet]. 2014 Nov 22 [cited 2017 Nov 8];14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260190/
Earnshaw VA, Smith LR, Chaudoir SR, Amico KR, Copenhaver MM. HIV stigma mechanisms and well-being among PLWH: a test of the HIV stigma framework. AIDS Behav. 2013;17(5):1785–95.
Garcia-Moreno C, Organizacion Mundial de la Salud. WHO multi-country study on women’s health and domestic violence against women: initial results on prevalence, health outcomes and women’s responses. Ginebra. Organización Mundial de la Salud; 2005.
Fairchild AJ, MacKinnon DP. A general model for testing mediation and moderation effects. Prev Sci. 2009;10(2):87–99.
Weiser SD, Palar K, Frongillo EA, Tsai AC, Kumbakumba E, dePee S, et al. Longitudinal assessment of associations between food insecurity, antiretroviral adherence and HIV treatment outcomes in rural Uganda. AIDS. 2014;28(1):115–20.
Cassel J. The contribution of the social environment to host resistance. Am J Epidemiol. 1976;104(2):107–23.
Cobb S. Social Support as a moderator of life stress. Psychosom Med. 1976;38(5):300–14.
Cohen S, Wills T. Stress, social support, and the buffering hypothesis. Psychol Bull. 1985;98(2):310–57.
Kollannoor-Samuel G, Wagner J, Damio G, Segura-Pérez S, Chhabra J, Vega-López S, et al. Social support modifies the association between household food insecurity and depression among Latinos with uncontrolled type 2 diabetes. J Immigr Minor Health. 2011;13(6):982–9.
Kapulsky L, Tang AM, Forrester JE. Food insecurity, depression, and social support in HIV-infected Hispanic individuals. J Immigr Minor Health. 2015;17(2):408–13.
Lehavot K, Huh D, Walters KL, King KM, Andrasik MP, Simoni JM. Buffering effects of general and medication-specific social support on the association between substance use and HIV medication adherence. AIDS Patient Care STDs. 2011;25(3):181–9.
Cutrona C, Suhr J. Controllability of stressful events and satisfaction with spouse support behaviors. Commun Res. 1992;19:154–74.
Sin NL, DiMatteo MR. Depression treatment enhances adherence to antiretroviral therapy: a meta-analysis. Ann Behav Med. 2014;47(3):259–69.