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Temporal Trends and Sociodemographic Correlates of PrEP Uptake in Tennessee, 2017

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Client-level data from two Tennessee-based PrEP navigation demonstration projects reported to the Tennessee Department of Health from January to December 2017 were evaluated to determine the proportion of clients who accepted, were linked to, and were prescribed PrEP. Disparities by age, race, transmission risk, and geographic region as well as trends over time were examined via bivariate and multivariable modified Poisson regression models accounting for potential confounders. Among 1385 PrEP-eligible individuals, 50.5% accepted, 33.4% were linked, and 27.3% were prescribed PrEP. PrEP uptake varied by age, race, and HIV transmission risk, and most disparities persisted across Tennessee throughout evaluation period. Multivariable regression models revealed significant independent associations between age, race/ethnicity, transmission risk, and region and PrEP acceptance and linkage. While differences in PrEP acceptance by race narrowed over time, success among black MSM was limited, underscoring a significant need to improve upstream PrEP continuum outcomes for this important population.

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The authors would like to acknowledge PrEP program directors Christopher Mathews and Katherine Buchman at the Tennessee Department of Health and the following CDC Project PrIDE team members: Cynthia Prather, Mary Neumann, Shaliondel Benton, Jarvis Carter Jr., Arin Freeman, Stephen Flores, Carla Galindo, Adrienne Herron, Tamika Hoyte, Wayne Johnson, Thomas Painter, Yamir Salabarría-Peña, Pilgrim Spikes, Mikel L. Walters, and Aisha Wilkes. In addition, the authors would like to acknowledge CDC’s Division of HIV Prevention (DHAP), Earl Dwayne Banks, Tennessee’s project officer for PS 12-1201, and the 12 talented and passionate PrEP navigators who have helped make PrEP a reality for hundreds of their clients. PrEP navigation activities were supported by the Centers for Disease Control and Prevention Grant PS 15-1506 (Project PrIDE) and Grant PS 12-1201.


This work was supported in part by the National Institutes of Health (K01 AI131895, PFR and R01 MH113438, ACP) and the NIH-funded Tennessee Center for AIDS Research (P30 AI110527).

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Correspondence to Meredith L. Brantley.

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Brantley, M.L., Rebeiro, P.F., Pettit, A.C. et al. Temporal Trends and Sociodemographic Correlates of PrEP Uptake in Tennessee, 2017. AIDS Behav 23 (Suppl 3), 304–312 (2019).

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