HIV Prevention Method Preferences Within Sexual Partnerships Reported by HIV-Negative MSM and TW in Tijuana, Mexico


To assess the potential for decreased condom use as pre-exposure prophylaxis (PrEP) is scaled-up in Latin America, we examined HIV prevention method preferences (neither PrEP nor condoms, condoms only, PrEP only, or PrEP with condoms) within 1302 sexual partnerships reported by 397 HIV-negative men who have sex with men (MSM) and transgender women (TW) in Tijuana, Mexico. Using PrEP with condoms (56%) was preferred to using condoms only (24%), using PrEP only (17%), and using neither PrEP nor condoms (3%). Compared to using condoms only, using PrEP only was preferred within primary (adjusted odds ratio [AOR] = 4.13, 95% confidence interval [CI] 1.92, 8.90) and condomless sex practicing (AOR = 6.97, 95% CI 3.92, 12.40) partnerships, suggesting PrEP use may not displace condom use among MSM and TW in Tijuana and other similar settings.

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The authors thank the study participants and staff without whom this study would not have been possible.


This work was supported by grants from the National Institute on Drug Abuse: K01DA040543 (HAP), R01DA037811 (TLP), and T32DA023356 (RP).

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Correspondence to H. A. Pines.

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Pines, H.A., Patrick, R., Smith, D.M. et al. HIV Prevention Method Preferences Within Sexual Partnerships Reported by HIV-Negative MSM and TW in Tijuana, Mexico. AIDS Behav 24, 839–846 (2020).

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  • Pre-exposure prophylaxis
  • HIV prevention method preferences
  • Men who have sex with men
  • Transgender women
  • Mexico