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Effect of an Educational Video to Increase Calls and Screening into an Anal Cancer Clinical Trial Among HIV+ Hispanics in PR: Results from a Randomized Controlled Behavioral Trial

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Abstract

Anal cancer incidence is higher in persons living with HIV/AIDS (PLWHA) than in the general population. Participation of PLWHA in anal cancer clinical trials (CTs) is essential; Hispanic PLWHA are underrepresented in CTs. We conducted a behavioral CT among 305 PLWHA in Puerto Rico to measure the efficacy of an educational video in increasing calls and screening into an anal cancer CT. Participants received printed educational materials on anal cancer and CTs; the intervention group also received an educational video. Outcome assessment based on follow-up interviews showed that printed materials increased awareness about CTs and high-resolution anoscopy (HRA), and willingness to participate in an anal cancer CT in both groups. However, the addition of the video increased the likelihood of participants to call the CT for orientation (RRadjusted = 1.66, 95% CI 1.00–2.76; p = 0.05) and pre-screening evaluation (RRadjusted = 1.70, 95% CI 0.95–3.03; p = 0.07). This intervention could help increase participation of Hispanics into anal cancer-related CTs.

Resumen

El cáncer anal es más común en personas con VIH/SIDA que en la población general. La participación de estas personas en ensayos clínicos (ECs) es esencial; los hispanos están sub-representados en los ECs. Realizamos un EC en 305 personas con VIH/SIDA en Puerto Rico, para medir la eficacia de un video educativo en aumentar las llamadas y el cernimiento a un EC de cáncer anal. Los participantes recibieron material impreso sobre cáncer anal y ECs; el grupo de intervención también observό el video educativo. Los resultados mostraron que los materiales impresos aumentaron la concienciación sobre ECs y la anoscopía, y la disposición de participar en un EC de cáncer anal. Sin embargo, el video educativo aumentό la posibilidad de que los participantes llamaran para orientación (RRajustado = 1.66, 95% CI 1.00–2.76; p = 0.05) y evaluación (RRajustado = 1.70, 95% CI 0.95–3.03; p = 0.07) para un ECs de cáncer anal. Esta intervención puede ayudar a aumentar la participación de Hispanos en ECs de cáncer anal.

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Acknowledgements

We want to thank Dr. Joel Palefsky from the University of California, San Francisco, for his suggestions to this manuscript. We also want acknowledge the support of the ANCHOR trial, and of Dr. Maribel Tirado, Cristina Muñoz and Diana Medina, members of ANCHOR's Puerto Rico site, in the execution of this study.

Funding

This study was funded by the UPRCC/MDACC Partnership for Excellence in Cancer Research (Award Number U54 CA096297/CA096300); and partially supported by the University of California Davis Comprehensive Cancer Center (Award Number U54 CA153499/CA093373) and the ANCHOR study (Award Number U01 CA121947), through funding of the National Cancer Institute, and by the Puerto Rico Clinical and Translational Research Consortium (Award Number U54MD007587), through funding of the National Institute of Minority Health and Health Disparities, of the National Institutes of Health.

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Authors and Affiliations

  1. Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico

    Ana P. Ortiz, Mark Machin & Vivian Colón-López

  2. Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

    Ana P. Ortiz & Darilyn Rivera-Collazo

  3. University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

    Marievelisse Soto-Salgado, Hilmaris Centeno-Girona & Daisy González

  4. Cancer Control/Cancer Health Disparities, Division of Hematology and Oncology, University of California, Davis Comprehensive Cancer Center, Sacramento, CA, USA

    Moon S. Chen Jr.

  5. Department of Health Services Administration, Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

    Vivian Colón-López

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  1. Ana P. Ortiz
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  2. Mark Machin
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  3. Marievelisse Soto-Salgado
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Correspondence to Ana P. Ortiz.

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All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Ortiz, A.P., Machin, M., Soto-Salgado, M. et al. Effect of an Educational Video to Increase Calls and Screening into an Anal Cancer Clinical Trial Among HIV+ Hispanics in PR: Results from a Randomized Controlled Behavioral Trial. AIDS Behav 23, 1135–1146 (2019). https://doi.org/10.1007/s10461-018-2330-z

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