Abstract
Late presentation to human immunodeficiency virus (HIV) care is an important concern for clinical outcomes and HIV prevention. Significant proportions of HIV-diagnosed persons are not timely linked to care following HIV diagnosis. We implemented and evaluated an intervention to link to care persons never in HIV care (NIC). Disease intervention specialists (DIS) traced persons presumed to be NIC since HIV diagnosis, offered them assistance with linkage to care, and elicited reasons for NIC. We examined the overall outcomes of the intervention and reasons for NIC. From January 2013 to December 2016, 121 persons were traced; 19% were linked to HIV care. Significantly (all P < 0.001) higher proportions of persons linked versus not linked to care were diagnosed < 1 year prior to being contacted by DIS (48% vs. 13%) or had a HIV-related laboratory test performed within 0–7 days of their diagnosis (87% vs. 33%). Among the 105 who provided reasons for NIC, most commonly reported were not believing one’s HIV diagnosis (30%) and lacking medical insurance (18%). Approximately 10% had been to a hospital emergency room and 20% to a primary care physician in the past year. Health department efforts to link persons NIC for HIV care were effective with a minority of eligible persons. Persons diagnosed within 1 year or who underwent HIV-related testing within 0–7 days of diagnosis were more likely to link to care. Newly HIV-diagnosed persons should be promptly referred to undergo all diagnostic testing and assessments on the same day or within 1 week of diagnosis.

Similar content being viewed by others
References
Guara G, Zona S, Menozzi M, et al. Late presentation increases risk and costs of non-infectious comorbidities in people with HIV: an Italian cost impact study. AIDS Res Ther. 2017;14:8. https://doi.org/10.1186/s12981-016-0129-4.
Honge BL, Jespersen S, Aunsborg J, et al. High prevalence and excess mortality of late presenters among HIV-1, HIV-2 and HIC-1/2 dually infected patients in Guinea-Bissau—a cohort study from West Africa. Pan Afr Med J. 2016;25:40. https://doi.org/10.11604/pamj.2016.25.40.8329.
Stinson K, Ford N, Cox V, et al. Patients lost to care are more likely to be viremic than patients still in care. Clin Infect Dis. 2014;58:1344–5.
Krawczyk C, Funkhouser E, Kilby J, Kaslow R, Bey A, Vermund S. Factors associated with delayed initiation of HIV medical care among infected persons attending a southern HIV/AIDS clinic. South Med J. 2006;99:472–81.
Centers for Disease Control and Prevention. Vital signs: HIV prevention through care and treatment—United States. MMWR. 2011;60:1618–23.
Gunthard HF, Aberg JA, Eron JJ, Hoy JF, et al. Antiretroviral treatment of adult HIV infection 2014 recommendations of the International Antiviral Society-USA panel. JAMA. 2014;312:410–25.
Cohen MS, Chen YQ, McCauley M, et al. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med. 2016;375:830–9.
Roger A, Bruun T, Cambiano V, et al. HIV transmission risk through condomless sex if HIV+ partner on suppressive ART: PARTNER study [Abstract 153LB]. Top Antivir Med. 2014;22(e-1):24–5.
Siedner MJ, Ng CK, Bassett IV, Katz IT, Bangsberg DR, Tsai AC. Trends in CD4 count at presentation to care and treatment initiation in sub-Saharan Africa, 2002–2013: a meta-analysis. Clin Infect Dis. 2015;60:1120–7.
Lundgren JD, Babiker AG, Gordin F, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015;373:795–807.
Centers for Disease Control and Prevention. National HIV Prevention Progress Report. 2015. http://www.cdc.gov/hiv/pdf/policies/progressreports/cdc-hiv-nationalprogressreport.pdf Accessed 12 Dec 2017.
HIV Epidemiology and Field Services Program. HIV Surveillance Annual Report, 2014. New York: New York City Department of Health and Mental Hygiene; 2015.
Torian LV, Wiewel EW, Liu K, Sackoff JE, Frieden TR. Risk factors for delayed initiation of medical care after diagnosis of human immunodeficiency virus. Arch Intern Med. 2008;168:1181–7.
Govindasamy D, Ford N, Kranzer K. Risk factors and facilitators for linkage to antiretroviral therapy care: a systematic review. AIDS. 2012;26:2059–67.
Gesesew HA, Tesfay Gebremedhin A, Demissie TD, Kerie MW, Sudhakar M, Mwanri L. Significant association between perceived HIV related stigma and late presentation for HIV/AIDS care in low and middle-income countries: a systematic review and meta-analysis. PLoS ONE. 2017;30(12):e0173928.
Udeagu CC, Webster TR, Bocour A, Michel P, Shepard CW. Lost or just not following up: public health effort to re-engage HIV-infected persons lost to follow-up into HIV medical care. AIDS. 2013;27:2271–9.
Buchacz K, Chen MJ, Parisi MK, Yoshida-Cervantes M, Antunez E, et al. Using HIV surveillance registry data to re-link persons to care: the RSVP project in San Francisco. PLoS ONE. 2015;10:e0118923. https://doi.org/10.1371/journal.pone.0118923.
Sabharwal CJ, Braunstein SL, Robbins RS, Shepard CW. Optimizing the use of surveillance data for monitoring the care status of persons recently diagnosed with HIV in NYC. J Acquir Immune Defic Syndr. 2014;65(5):571–8. https://doi.org/10.1097/qai.0000000000000077.
Molitor F, Waltermeyer J, Mendoza M, Kuenneth C, et al. Locating and linking to medical care HIV-positive persons without a history of care: findings from the California Bridge Project. AIDS Care. 2006;18:456–9.
Saleem HT, Mushi D, Hassan S, Bruce RD, et al. “Can’t you initiate me here?”: challenges to timely initiation on antiretroviral therapy among methadone clients in Dar es Salaam, Tanzania. Int J Drug Policy. 2016;30:59–65.
Boyer S, Iwuji C, Gosset A, Protopopescu C, et al. Factors associated with antiretroviral treatment initiation among HIV-positive individuals linked to care within a universal test and treat programme: early findings of the ANRS 12249 TasP trial in rural South Africa. AIDS Care. 2016;28(Suppl 3):39–51.
Layer EH, Kennedy CE, Beckham SW, Mbwambo JK, et al. Multi-level factors affecting entry into and engagement in the HIV continuum of care in Iringa, Tanzania. PLoS ONE. 2014;9:e104961. https://doi.org/10.1371/journal.pone.0104961.
Reddy EA, Agala CB, Maro VP, Ostermann J, et al. Test site predicts HIV care linkage and antiretroviral therapy initiation: a prospective 3.5 year cohort study of HIV-positive testers in northern Tanzania. BMC Infect Dis. 2014;16:497. https://doi.org/10.1186/s12879-016-1804-8.
Health Department Announces Historic Expansion of HIV and STI Services at Sexual Health Clinics. Press Release, February 10, 2017. Available at: https://www1.nyc.gov/site/doh/about/press/pr2017/pr003-17.page.
Kredo T, Adeniyi FB, Bateganya M, Pienaar ED. Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy. Cochrane Database Syst Rev. 2014. https://doi.org/10.1002/14651858.CD007331.pub3.
Schwitters AM. Preliminary results after implementation of a universal treatment program (test and start) for persons living with HIV infection—Lesotho, October 2015–February 2017. MMWR. 2017;30:813.
Nwanyanwu R, Alcaide M, Rodriguez A, Soni M, et al. Implementation of HIV test and treat rapid response antiretroviral initiation program in a Southern city with high HIV incidence. Open Forum Infect Dis. 2017;4(Suppl 1):S441.
Halperin J, Holm P, Butler I, Conner K, Van Sickels N. Linkage and antiretroviral therapy within 72 hours at a Ryan White-funded FQHC in the deep South. Open Forum Infect Dis. 2017;4(Suppl 1):S440–1.
Hoffman S, Exner TM, Lince-Deroche N, Leu C-S, Phillip JL, et al. Immediate blood draw for CD4+ cell count is associated with linkage to care in Durban, South Africa: findings from Pathways to Engagement in HIV Care. PLoS ONE. 2016;11:e0162085. https://doi.org/10.1371/journal.pone.0162085.
Koeing SP, Dorvi N, Hedt-Gauthier BL, et al. Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons with HIV: a randomized unblended trial. PLoS Med. 2017;14:e1002357.
Surthar AB, Ford N, Bachanas PJ, Wong VJ, et al. Towards universal voluntary HIV testing and counseling: a systematic review and meta-analysis of community-based approaches. PLoS Med. 2013;10:e1001496.
MacPherson P, Lalloo DG, Webb EL, Maheswaran H, Choko AT, et al. Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomize clinical trial. JAMA. 2014;23(312):372–9.
Acknowledgements
The authors are grateful to the New York City HIV case workers for their dedication and hard work in locating and assisting HIV-diagnosed persons with linkage to care and partner services.
Funding
Funding for this program was provided by Ryan White HIV Care Program Part A, Grant #93.914.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflict of interest.
Ethical Approval
No institutional review board approval was necessary because this is a secondary analysis of data collected as part of the New York City Department of Health and Mental Hygiene routine case and partner services program.
Informed Consent
For this type of study, no formal consent is necessary.
Rights and permissions
About this article
Cite this article
Udeagu, CC.N., Huang, J. & Misra, K. Duration Since Never in HIV Care and Immediate Blood-Draw After HIV Diagnosis are Associated with Willingness to Link to Care Following Health Department Outreach, New York City. AIDS Behav 23, 386–394 (2019). https://doi.org/10.1007/s10461-018-2246-7
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1007/s10461-018-2246-7


