This study investigated the acceptability of daily use of free oral pre-exposure prophylaxis (PrEP) and associated factors among transgender women sex workers in Shenyang, China, following a briefing on PrEP. A total of 183 HIV negative or sero-status unknown participants completed the cross-sectional survey. The prevalence of acceptability of daily use of free oral PrEP was 61.2%. Adjusting for education level and monthly income, variables on negative attitudes toward PrEP (i.e., having concerns about the side-effects of PrEP) [Adjusted odds ratios (AOR): 0.26], perceived subjective norms (i.e., perceiving support from male partners to take PrEP) (AOR: 2.08), and perceived behavioral control (e.g., perceiving complete control over using PrEP) (AOR: 2.10–16.72) were significantly associated with acceptability of daily use of free oral PrEP. In addition, experiencing violence during sex work, perceived risk of contracting HIV from clients and probable anxiety were also significant. Future PrEP promotion campaigns should consider these factors.
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Adjusted odds ratios
Condomless receptive anal intercourse
Exploratory factor analysis
Female sex workers
Human immunodeficiency virus
Men who have sex with men
Male sex workers
Non-regular sex partner
Univariate odds ratios
Multivariate odds ratios
Regular sex partner
Sexually transmitted diseases
Tenofovir disoproxil fumarate
Theory of planned behavior
World Health Organization
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Conflict of interest
The authors declare that they have no conflict of interest.
Research Involving Human Participants
All procedures performed in studies involving human participants were in accordance with the ethical standards of the Survey and Behavioural Research Ethics Committee, the Chinese University of Hong Kong and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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Wang, Z., Lau, J.T.F., Yang, X. et al. Acceptability of Daily Use of Free Oral Pre-exposure Prophylaxis (PrEP) Among Transgender Women Sex Workers in Shenyang, China. AIDS Behav 21, 3287–3298 (2017). https://doi.org/10.1007/s10461-017-1869-4
- Pre-exposure prophylaxis
- Transgender women sex workers
- Theory of planned behavior