Prescription Opioid Use is Associated with Virologic Failure in People Living with HIV
Prescription opioid misuse is a rising epidemic in the U.S., and people living with HIV are at increased risk. We assessed the association between prescription opioid use and virologic failure in HIV+ patients in the South Texas HIV Cohort. We found prescription opioid use was significantly associated with virologic failure, after adjustment for age, race, gender, insurance status, years living with HIV, reported HIV risk factor, chronic hepatitis C virus infection, current substance abuse, and care engagement. These findings suggest that opioid analgesic use may have negative consequences beyond misuse in people living with HIV.
KeywordsPrescription opioid HIV Virologic outcome Narcotic
We gratefully acknowledge the faculty and staff at the FFACTS HIV outpatient clinic of University Health System. We also gratefully acknowledge the faculty and staff at the University of Texas Health Science Center at San Antonio. We would like to thank the Clinical and Translational Science Award program for their Pilot Funding Award CTSA 1 UL1 RR025767, and the National Institutes of Health K23 Career Development Award 7K23AI081538.
The study was funded by the CTSA Pilot funding award CTSA1 UL1 RR025767 and NIH K23 Career Development Award 7K23AI081538.
Compliance with Ethical Standards
Conflict of interest
The authors of this manuscript declare no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The University of Texas Health Science Center San Antonio Institutional Review Board determined that individual patient consent could be waived for this study, as this is a retrospective analysis of existing electronic medical records data.”
Research Involving Human Participants and/or Animals
Human subjects activities under this study was approved by the University of Texas Health Science Center San Antonio Institutional Review Board.
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