Skip to main content

Advertisement

SpringerLink
Log in

Combining Text Messaging and Telephone Counseling to Increase Varenicline Adherence and Smoking Abstinence Among Cigarette Smokers Living with HIV: A Randomized Controlled Study

  • Original Paper
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

Abstract

Smoking represents an important health risk for people living with HIV (PLHIV). Low adherence to smoking cessation pharmacotherapy may limit treatment effectiveness. In this study, 158 participants recruited from three HIV care centers in New York City were randomized to receive 12-weeks of varenicline (Chantix) either alone as standard care (SC) or in combination with text message (TM) support or TM plus cell phone-delivered adherence-focused motivational and behavioral therapy (ABT). Generalized linear mixed-effect models found a significant decline in varenicline adherence from week 1–12 across treatment groups. At 12-weeks, the probability of smoking abstinence was significantly higher in SC+TM+ABT than in SC. The study demonstrates the feasibility of delivering adherence-focused interventions to PLHIV who smoke. Findings suggest intensive behavioral support is an important component of an effective smoking cessation intervention for this population, and a focus on improving adherence self-efficacy may lead to more consistent adherence and higher smoking abstinence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Burkhalter JE, Springer CM, Chhabra R, et al. Tobacco use and readiness to quit smoking in low-income HIV-infected persons. Nic Tob Res. 2005;7(4):511–22.

    Article  Google Scholar 

  2. Cooperman NA. Current research on cigarette smoking among people with HIV. Curr Addict Rep. 2016;3(1):19–26.

    Article  Google Scholar 

  3. Mdodo R, Frazier EL, Dube SR, Mattson CL, Sutton MY, Brooks JT, Skarbinski J. Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys. Ann Intern Med. 2015;162(5):335–44.

    Article  PubMed  Google Scholar 

  4. Sackoff JE, Hanna DB, Pfeiffer MR, et al. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med. 2006;145(6):397–406.

    Article  PubMed  Google Scholar 

  5. Helleberg M, May MT, Ingle SM, et al. Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America. AIDS. 2015;29(2):221–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hile SJ, Feldman MB, Alexy ER, Irvine MK. Recent tobacco smoking is associated with poor HIV medical outcomes among HIV-infected individuals in New York. AIDS Behav. 2016;20(8):1722–9.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Reynolds NR. Cigarette smoking and HIV: more evidence for action. AIDS Educ Prev. 2009;21(suppl 3):106.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Niaura R, Chander G, Hutton H, Stanton C. Interventions to address chronic disease and HIV: strategies to promote smoking cessation among HIV-infected individuals. Curr HIV/AIDS Rep. 2012;9(4):375–84.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Cioe PA. Smoking cessation interventions in HIV-infected adults in North America: a literature review. J Addict Behav Ther Rehabil. 2013;2(3):1000112.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Shuter J, Morales DA, Considine-Dunn SE, et al. Feasibility and preliminary efficacy of a web-based smoking cessation intervention for HIV-infected smokers: a randomized controlled trial. J Acquir Immune Defic Syndr. 2014;67(1):59–66.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Vidrine DJ, Marks RM, Arduino RC, et al. Efficacy of cell phone–delivered smoking cessation counseling for persons living with HIV/AIDS: 3-month outcomes. Nicotine Tob Res. 2012;14(1):106–10.

    Article  PubMed  Google Scholar 

  12. Gritz ER, Danysh HE, Fletcher FE, et al. Long-term outcomes of a cell phone-delivered intervention for smokers living with HIV/AIDS. Clin Infect Dis. 2013;57(4):608–15.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Moadel AB, Bernstein SL, Mermelstein RJ, et al. A randomized controlled trial of a tailored group smoking cessation intervention for HIV-infected smokers. J Acquir Immune Defic Syndr. 2012;61(2):208–15.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Lloyd-Richardson EE, Stanton CA, Papandonatos GD, et al. Motivation and patch treatment for HIV+ smokers: a randomized controlled trial. Addiction. 2009;104(11):1891–900.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Stanton CA, Papandonatos GD, Shuter J, Bicki A, Lloyd-Richardson EE, de Dios MA, Morrow KM, Makgoeng SB, Tashima KT, Niaura RS. Outcomes of a tailored intervention for cigarette smoking cessation among latinos living with HIV/AIDS. Nicotine Tob Res. 2015;17(8):975–82.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ingersoll KS, Cropsey KL, Heckman CJ. A test of motivational plus nicotine replacement interventions for HIV positive smokers. AIDS Behav. 2009;13(3):545–54.

    Article  PubMed  Google Scholar 

  17. Humfleet GL, Hall SM, Delucchi KL, et al. A randomized clinical trial of smoking cessation treatments provided in HIV clinical care settings. Nicotine Tob Res. 2013;15(8):1436–45.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Fiore MC, Jaen CR, Baker TB, et al., editors. Treating tobacco use and dependence: 2008 update. Clinical practice guideline. Rockville: U.S. DIANE Publishing; 2008.

    Google Scholar 

  19. Catz SL, Jack LM, McClure JB, et al. Adherence to varenicline in the COMPASS smoking cessation intervention trial. Nicotine Tob Res. 2011;5(5):361–8.

    Article  Google Scholar 

  20. Liberman JN, Lichtenfeld MJ, Galaznik A, et al. Adherence to varenicline and associated smoking cessation in a community-based patient setting. J Manag Care Pharm. 2013;19(2):125–31.

    PubMed  Google Scholar 

  21. Stanton CA, Lloyd-Richardson EE, Papandonatos GD, et al. Mediators of the relationship between nicotine replacement therapy and smoking abstinence among people living with HIV/AIDS. AIDS Educ Prev. 2009;21(suppl 3):65–80.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Hays JT, Leischow SJ, Lawrence D, et al. Adherence to treatment for tobacco dependence: association with smoking abstinence and predictors of adherence. Nicotine Tob Res. 2010;12(6):574–81.

    Article  PubMed  Google Scholar 

  23. Raupach T, Brown J, Herbec A, et al. A systematic review of studies assessing the association between adherence to smoking cessation medication and treatment success. Addiction. 2014;109(1):35–43.

    Article  PubMed  Google Scholar 

  24. Alterman AI, Gariti P, Cook TG, et al. Nicodermal patch adherence and its correlates. Drug Alcohol Depend. 1999;53(2):159–65.

    Article  CAS  PubMed  Google Scholar 

  25. Fucito LM, Toll BA, Salovey P, et al. Beliefs and attitudes about bupropion: Implications for medication adherence and smoking cessation treatment. Psychol Addict Behav. 2009;23(2):373–9.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Mooney ME, Sayre SL, Hokanson PS, et al. Adding MEMS feedback to behavioral smoking cessation therapy increases compliance with bupropion: a replication and extension study. Addict Behav. 2007;32(4):875–80.

    Article  PubMed  Google Scholar 

  27. Finitsis DJ, Pellowski JA, Johnson BT. Text message intervention designs to promote adherence to antiretroviral therapy (ART): a meta-analysis of randomized controlled trials. PLoS One. 2014;9(2):e88166.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Bock B, Heron K, Jennings E, et al. A text message delivered smoking cessation intervention: the initial trial of TXT-2-Quit: randomized controlled trial. JMIR MHealth UHealth. 2013;1(2):e17.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Bock BC, Heron KE, Jennings EG, et al. User preferences for a text message-based smoking cessation intervention. Health Educ Behav. 2013;40(2):152–9.

    Article  PubMed  Google Scholar 

  30. Whittaker R, McRobbie H, Bullen C, et al. Mobile phone-based interventions for smoking cessation. Cochrane Database Syst Rev. 2012; (11).

  31. Spohr SA, Nandy R, Gandhiraj D, et al. Efficacy of SMS text message interventions for smoking cessation: a meta-analysis. J Subst Abuse Treat. 2015;56:1–10.

    Article  PubMed  Google Scholar 

  32. Skinner HA. The drug abuse screening test. Addict Behav. 1982;7(4):363–71.

    Article  CAS  PubMed  Google Scholar 

  33. Bush K, Kihlavan DR, McConell MB, et al. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Arch Int Med. 1998;15(16):1789–95.

    Article  Google Scholar 

  34. Heatherton TF, Kozlowski LT, Frecker RC, et al. Measuring the heaviness of smoking: using self-reported time to the first cigarette of the day and number of cigarettes smoked per day. Br J Addict. 1989;84(7):791–800.

    Article  CAS  PubMed  Google Scholar 

  35. Bradley KA, DeBenedetti AF, Volk RJ, et al. AUDIT-C as a brief screen for alcohol misuse in primary care. Alcohol Clin Exp Res. 2007;31(7):1208–17.

    Article  PubMed  Google Scholar 

  36. Berman AH, Bergman H, Palmstierna T, et al. Evaluation of the drug use disorders identification test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample. Eur Addict Res. 2005;11(1):22–31.

    Article  PubMed  Google Scholar 

  37. The lifewindows project team [Internet]. storrs (CT): the lifewindows information motivation behavioral skills ART adherence questionnaire (LW-IMBAAQ). Center for health, intervention, and prevention, university of connecticut; 2006 [cited 2015 Jul 28]. Available from: http://www.chip.uconn.edu/chipweb/documents/Research/F_LWIMBARTQuestionnaire.pdf.

  38. Fernandez S, Chaplin W, Schoenthaler AM, et al. Revision and validation of the medication adherence self-efficacy scale (MASES) in hypertensive African Americans. J Behav Med. 2008;31(6):453–62.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Johnson MO, Neilands TB, Dilworth SE, et al. The role of self-efficacy in HIV treatment adherence: validation of the HIV Treatment Adherence Self-Efficacy Scale (HIVASES). J Behav Med. 2007;30(5):359–70.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Nollen NL, Mayo MS, Ahluwalia JS, et al. Factors associated with discontinuation of bupropion and counseling among African American light smokers in a randomized clinical trial. Ann Behav Med. 2013;46(3):336–48.

    Article  PubMed  Google Scholar 

  41. Buchanan TA, Carla BJ, Cox LS, et al. Adherence to varenicline among African American smokers: an exploratory analysis comparing plasma concentration, pill count, and self-report. Nicotine Tob Res. 2012;14(9):1083–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Nollen NL, Cox LS, Nazir N, et al. A pilot clinical trial of varenicline for smoking cessation in black smokers. Nicotine Tob Res. 2011;13(9):868–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Fisher JD, Amico KR, Fisher WA, et al. The information-motivation-behavioral skills model of antiretroviral adherence and its applications. Curr HIV/AIDS Rep. 2008;5(4):193–203.

    Article  PubMed  Google Scholar 

  44. Bandura A. Regulation of cognitive processes through perceived self-efficacy. Dev Psychol. 1989;25(5):729–35.

    Article  Google Scholar 

  45. Fishbein M. A reasoned action approach to health promotion. Med Decis Making. 2008;28(6):834–44.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Fisher JD, Fisher WA, Amico KR, et al. An information-motivation-behavioral skills model of adherence to antiretroviral therapy. Health Psychol. 2006;25(4):462–73.

    Article  PubMed  Google Scholar 

  47. Starace F, Massa A, Amico KR, et al. Adherence to antiretroviral therapy: an empirical test of the information-motivation-behavioral skills model. Health Psychol. 2006;25:153–62.

    Article  PubMed  Google Scholar 

  48. Marlatt GA, Donovan DM, editors. Relapse prevention: maintenance strategies in the treatment of addictive behaviors. New York: Guilford Press; 2005.

    Google Scholar 

  49. Osterberg L, Blaschke T. Adherence to medication. New Engl J Med. 2005;353(5):487–97.

    Article  CAS  PubMed  Google Scholar 

  50. Free C, Phillips G, Galli L, et al. The effectiveness of mobile-health technology-based health behaviour change or disease management interventions for health care consumers: a systematic review. PLoS Med. 2013;10(1):e1001362.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Free C, Whittaker R, Knight R, et al. Txt2stop: a pilot randomised controlled trial of mobile phone-based smoking cessation support. Tob Control. 2009;18(2):88–91.

    Article  CAS  PubMed  Google Scholar 

  52. National Cancer Institute [Internet]. Bethesda (MD): SmokefreeTXT; 2011- [cited 2015 Jul 27]. Available from: http://smokefree.gov/SmokefreeTXT/.

  53. Lewis MA, Uhrig JD, Bann CM, et al. Tailored text messaging intervention for HIV adherence: a proof-of-concept study. Health Psychol. 2013;32(3):248–53.

    Article  PubMed  Google Scholar 

  54. Krebs P, Tseng TY, Pham H, et al. Formative evaluation of a text messaging intervention to promote varenicline adherence among tobacco-dependent persons with HIV. J Health Commun. 2015;9:1–5.

    Google Scholar 

  55. Colby SM, Monti PM, Barnett NP, et al. Brief motivational interviewing in a hospital setting for adolescent smoking: a preliminary study. J Consult Clin Psychol. 1998;66(3):574–8.

    Article  CAS  PubMed  Google Scholar 

  56. Hall SM, Muñoz RF, Reus VI. Cognitive-behavioral intervention increases abstinence rates for depressive-history smokers. J Consult Clin Psychol. 1994;62(1):141–6.

    Article  CAS  PubMed  Google Scholar 

  57. Miller WR, Wilbourne PL. Mesa Grande: a methodological analysis of clinical trials of treatments for alcohol use disorders. Addiction. 2002;97(3):265–77.

    Article  PubMed  Google Scholar 

  58. Hollands GJ, McDermott MS, Lindson-Hawley N, et al. Interventions to increase adherence to medications for tobacco dependence. Cochrane Database Syst Rev. 2015; (2).

  59. Bellg AJ, Borrelli B, Resnick B, et al. Enhancing treatment fidelity in health behavior change studies: best practices and recommendations from the NIH behavior change consortium. Health Psychol. 2004;23(5):443–51.

    Article  PubMed  Google Scholar 

  60. StataCorp, StataCorp. Stata statistical software: release 14. College Station: StataCorp LP; 2015.

    Google Scholar 

  61. Nakagawa S, Schielzeth H. A general and simple method for obtaining R2 from generalized linear mixed-effects models. Methods Ecol Evol. 2013;4(2):133–42.

    Article  Google Scholar 

  62. Lane C, Huws-Thomas M, Hood K, et al. Measuring adaptations of motivational interviewing: the development and validation of the behavior change counseling index (BECCI). Patient Educ Couns. 2005;56(2):166–73.

    Article  PubMed  Google Scholar 

  63. Hardy H, Kumar V, Doros G, et al. Randomized controlled trial of a personalized cellular phone reminder system to enhance adherence to antiretroviral therapy. AIDS Patient Care STDs. 2011;25(3):153–61.

    PubMed  PubMed Central  Google Scholar 

  64. Baranoski AS, Meuser E, Hardy H, et al. Patient and provider perspectives on cellular phone-based technology to improve HIV treatment adherence. AIDS Care. 2014;26(1):26–32.

    Article  PubMed  Google Scholar 

  65. Reynolds NR, Testa MA, Marc LG, et al. Factors influencing medication adherence beliefs and self-efficacy in persons naive to antiretroviral therapy: a multicenter, cross-sectional study. AIDS Behav. 2004;8(2):141–50.

    Article  PubMed  Google Scholar 

  66. Vidrine DJ, Arduino RC, Lazev AB, et al. A randomized trial of a proactive cellular telephone intervention for smokers living with HIV/AIDS. Aids. 2006;20(2):253–60.

    Article  PubMed  Google Scholar 

Download references

Funding

This research was sponsored by the National Institutes of Drug Abuse of the National Institutes of Health (R34 DA031636001A1, http:\\www.ClinicalTrials.gov ID# NCT01898195). The study medication was provided by Pfizer Inc, Mission, KS. This research was supported by the Center for Drug Use and HIV Research (CDUHR-P30 DA011041). Dr. Sherman is supported in part by a Grant from NIDA (#1K24DA038345).

Author information

Authors and Affiliations

  1. Department of Population Health, New York University School of Medicine, 227 East 30th Street, Room 708, New York, NY, 10016, USA

    Tuo-Yen Tseng, Paul Krebs, Antoinette Schoenthaler, Selena Wong, Scott Sherman, Mirelis Gonzalez & Donna Shelley

  2. Behavioral Health Research, St. Luke’s Roosevelt Hospital, New York, NY, USA

    Antonio Urbina

  3. New York University Rory Meyers College of Nursing and Center for Drug Use and HIV Research, New York, NY, USA

    Charles M. Cleland

Authors
  1. Tuo-Yen Tseng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Krebs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antoinette Schoenthaler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Selena Wong
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Scott Sherman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mirelis Gonzalez
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Antonio Urbina
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Charles M. Cleland
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Donna Shelley
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Donna Shelley.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tseng, TY., Krebs, P., Schoenthaler, A. et al. Combining Text Messaging and Telephone Counseling to Increase Varenicline Adherence and Smoking Abstinence Among Cigarette Smokers Living with HIV: A Randomized Controlled Study. AIDS Behav 21, 1964–1974 (2017). https://doi.org/10.1007/s10461-016-1538-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-016-1538-z

Keywords

Search

Navigation