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Gender Differences and Psychosocial Factors Associated with Quality of Life Among ART Initiators in Oromia, Ethiopia

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Abstract

Health-related quality of life (HRQoL) is an important outcome to assess among persons living with HIV/AIDS, but few studies have been conducted in sub-Saharan Africa. We examined HRQoL among 1180 ART-initiating adults from six clinics in Ethiopia in 2012–2013, and compared the correlates of two subscale scores between women and men. Women scored significantly higher than men on both overall function (8.4 points higher) and life satisfaction (6.3 points higher). In multivariable models, psychological distress, low CD4+ count, unemployment, and food insecurity were associated with lower quality of life scores among women and men. Men whose last sexual encounter occurred 3 months to 1 year from the interview date had lower overall function and life satisfaction scores. Men between the ages of 30–39 had lower overall function scores. Protestant women and women in the low-middle social support category had lower life satisfaction scores. Assessment of HRQoL over time will help inform HIV care and treatment practices to ensure favorable patient outcomes.

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References

  1. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med. 1993;118(8):622–9.

    Article  CAS  PubMed  Google Scholar 

  2. Safren SA, Hendriksen ES, Smeaton L, et al. Quality of life among individuals with HIV starting antiretroviral therapy in diverse resource-limited areas of the world. AIDS Behav. 2012;16(2):266–77.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Liu C, Johnson L, Ostrow D, Silvestre A, Visscher B, Jacobson LP. Predictors for lower quality of life in the HAART era among HIV-infected men. J Acquir Immune Defic Syndr. 2006;42(4):470–7.

    Article  PubMed  Google Scholar 

  4. Mandorfer M, Payer BA, Scheiner B, et al. Health-related quality of life and severity of fatigue in HIV/HCV co-infected patients before, during, and after antiviral therapy with pegylated interferon plus ribavirin. Liver Int. 2014;34(1):69–77.

    Article  CAS  PubMed  Google Scholar 

  5. Merlins JS, Tucker RO, Saag MS, Selwyn PA. The role of palliative care in the current HIV treatment era in developed countries. Top Antivir Med. 2013;21(1):20–6.

    PubMed  Google Scholar 

  6. World Health Organization. WHO Constitution. Geneva: WHO; 1948.

    Google Scholar 

  7. Romero M, Vivas-Consuelo D, Alvis-Guzman N. Is Health Related Quality of Life (HRQoL) a valid indicator for health systems evaluation? SpringerPlus. 2013;2:664.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013;382(9903):1525–33.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Vigneshwaran E, Padmanabhareddy Y, Devanna N, Alvarez-Uria G. gender differences in health related quality of life of people living with HIV/AIDS in the era of highly active antiretroviral therapy. N Am J Med Sci. 2013;5(2):102–7.

    Article  PubMed  PubMed Central  Google Scholar 

  10. MacArthur RD, DuPont HL. Etiology and pharmacologic management of noninfectious diarrhea in HIV-infected individuals in the highly active antiretroviral therapy era. Clin Infect Dis. 2012;55(6):860–7.

    Article  CAS  PubMed  Google Scholar 

  11. Jia H, Uphold CR, Wu S, Chen GJ, Duncan PW. Predictors of changes in health-related quality of life among men with HIV infection in the HAART era. AIDS Patient Care STDS. 2005;19(6):395–405.

    Article  PubMed  Google Scholar 

  12. Tomita A, Garrett N, Werner L, et al. Health-related quality of life dynamics of HIV-positive South African Women up to ART initiation: evidence from the CAPRISA 002 acute infection cohort study. AIDS Behav. 2014;18(6):1114–23.

    PubMed  PubMed Central  Google Scholar 

  13. de Boer-van der Kolk IM, Sprangers MA, Prins JM, Smit C, de Wolf F, Nieuwkerk PT. Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: a study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort. Clin Infect Dis. 2010;50(2):255–63.

    Article  PubMed  Google Scholar 

  14. Mannheimer SB, Matts J, Telzak E, et al. Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence. AIDS Care. 2005;17(1):10–22.

    Article  CAS  PubMed  Google Scholar 

  15. Rueda S, Raboud J, Plankey M, et al. Labor force participation and health-related quality of life in HIV-positive men who have sex with men: the Multicenter AIDS Cohort Study. AIDS Behav. 2012;16(8):2350–60.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Greeff M, Chepuka LM, Chilemba W, et al. Using an innovative mixed method methodology to investigate the appropriateness of a quantitative instrument in an African context: Antiretroviral treatment and quality of life. AIDS Care. 2013. doi:10.1080/09540121.2013.859651.

    PubMed  Google Scholar 

  17. Igumbor J, Stewart A, Holzemer W. Comparison of the health-related quality of life, CD4 count and viral load of AIDS patients and people with HIV who have been on treatment for 12 months in rural South Africa. SAHARA J. 2013;10(1):25–31.

    PubMed  PubMed Central  Google Scholar 

  18. Odek WO. Social networks and mental health among people living with human immunodeficiency virus (HIV) in Johannesburg, South Africa. AIDS Care. 2014;26(8):1042–9.

    Article  PubMed  Google Scholar 

  19. Geary C, Parker W, Rogers S, et al. Gender differences in HIV disclosure, stigma, and perceptions of health. AIDS Care. 2014;26(11):1419–25.

    Article  PubMed  Google Scholar 

  20. Richardson ET, Collins SE, Kung T, et al. Gender inequality and HIV transmission: a global analysis. J Int AIDS Soc. 2014;17:19035.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hare AQ, Ordonez CE, Johnson BA, et al. Gender-specific risk factors for virologic failure in KwaZulu-Natal: automobile ownership and financial insecurity. AIDS Behav. 2014;18(11):2219–29.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Ethiopia FDRo. Country progress report on the HIV Response, 2014. Addis Ababa, 2014.

  23. Wood-Dauphinee S. Assessing quality of life in clinical research: from where have we come and where are we going? J Clin Epidemiol. 1999;52(4):355–63.

    Article  CAS  PubMed  Google Scholar 

  24. Drewes J, Gusy B, Ruden U. More than 20 years of research into the quality of life of people with HIV and AIDS—a descriptive review of study characteristics and methodological approaches of published empirical studies. J Int Assoc Provid AIDS Care. 2013;12(1):18–22.

    Article  PubMed  Google Scholar 

  25. Holmes WC, Shea JA. Performance of a new, HIV/AIDS-targeted quality of life (HAT-QoL) instrument in asymptomatic seropositive individuals. Qual Life Res. 1997;6(6):561–71.

    Article  CAS  PubMed  Google Scholar 

  26. Holmes WC, Bilker WB, Wang H, Chapman J, Gross R. HIV/AIDS-specific quality of life and adherence to antiretroviral therapy over time. J Acquir Immune Defic Syndr. 2007;46(3):323–7.

    Article  PubMed  Google Scholar 

  27. Taylor TN, Dolezal C, Tross S, Holmes WC. Reliability and validity of two HIV/AIDS-specific quality of life instruments adapted for use in HIV-positive Zimbabweans. AIDS Care. 2009;21(5):598–607.

    Article  PubMed  Google Scholar 

  28. Phaladze NA, Human S, Dlamini SB, et al. Quality of life and the concept of “living well” with HIV/AIDS in sub-Saharan Africa. J Nurs Scholarsh. 2005;37(2):120–6.

    Article  PubMed  Google Scholar 

  29. Holmes WC, Shea JA. A new HIV/AIDS-targeted quality of life (HAT-QoL) instrument: development, reliability, and validity. Med Care. 1998;36(2):138–54.

    Article  CAS  PubMed  Google Scholar 

  30. Kessler RC, Price RH, Wortman CB. Social factors in psychopathology: stress, social support, and coping processes. Annu Rev Psychol. 1985;36:531–72.

    Article  CAS  PubMed  Google Scholar 

  31. Drummond MF. The economic impact of AIDS. AIDS Care. 1989;1(2):216–8.

    Article  CAS  PubMed  Google Scholar 

  32. Kessler RC, Andrews G, Colpe LJ, et al. Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med. 2002;32(6):959–76.

    Article  CAS  PubMed  Google Scholar 

  33. El-Sadr WM, Holmes CB, Mugyenyi P, et al. Scale-up of HIV treatment through PEPFAR: a historic public health achievement. J Acquir Immune Defic Syndr. 2012;60(Suppl 3):S96–104.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Lahuerta M, Ue F, Hoffman S, et al. The problem of late ART initiation in Sub-Saharan Africa: a transient aspect of scale-up or a long-term phenomenon? J Health Care Poor Underserved. 2013;24(1):359–83.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Lahuerta M, Wu Y, Hoffman S, et al. Advanced HIV disease at entry into HIV care and initiation of antiretroviral therapy during 2006–2011: findings from four sub-saharan African countries. Clin Infect Dis. 2014;58(3):432–41.

    Article  CAS  PubMed  Google Scholar 

  36. Tomori C, Kennedy CE, Brahmbhatt H, et al. Barriers and facilitators of retention in HIV care and treatment services in Iringa, Tanzania: the importance of socioeconomic and sociocultural factors. AIDS Care. 2013. doi:10.1080/09540121.2013.861574.

    PubMed  Google Scholar 

  37. Risher K, Adams D, Sithole B, et al. Sexual stigma and discrimination as barriers to seeking appropriate healthcare among men who have sex with men in Swaziland. J Int AIDS Soc. 2013;16(3 Suppl 2):18715.

    PubMed  PubMed Central  Google Scholar 

  38. Ayiga N, Nambooze H, Nalugo S, Kaye D, Katamba A. The impact of HIV/AIDS stigma on HIV counseling and testing in a high HIV prevalence population in Uganda. Afr Health Sci. 2013;13(2):278–86.

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Kagee A. Psychological distress among persons living with HIV, hypertension, and diabetes. AIDS Care. 2010;22(12):1517–21.

    Article  PubMed  Google Scholar 

  40. Selman L, Simms V, Penfold S, et al. ‘My dreams are shuttered down and it hurts lots’—a qualitative study of palliative care needs and their management by HIV outpatient services in Kenya and Uganda. BMC Palliat Care. 2013;12(1):35.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Fleishman JA, Sherbourne CD, Cleary PD, Wu AW, Crystal S, Hays RD. Patterns of coping among persons with HIV infection: configurations, correlates, and change. Am J Commun Psychol. 2003;32(1–2):187–204.

    Article  Google Scholar 

  42. Garcia J, Hromi-Fiedler A, Mazur RE, et al. Persistent household food insecurity, HIV, and maternal stress in peri-urban Ghana. BMC Public Health. 2013;13:215.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Studies ESoP. Gender inequality and women’s empowerment, Addis Ababa: United Nations Population Fund (UNFPA), 2008.

  44. Casale M, Wild L, Cluver L, Kuo C. Social support as a protective factor for depression among women caring for children in HIV-endemic South Africa. J Behav Med. 2015;38(1):17–27.

    Article  PubMed  Google Scholar 

  45. Breet E, Kagee A, Seedat S. HIV-related stigma and symptoms of post-traumatic stress disorder and depression in HIV-infected individuals: does social support play a mediating or moderating role? AIDS Care. 2014;26(8):947–51.

    Article  PubMed  Google Scholar 

  46. Palermo T, Rawat R, Weiser SD, Kadiyala S. Food access and diet quality are associated with quality of life outcomes among HIV-infected individuals in Uganda. PLoS One. 2013;8(4):e62353.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Sori AT. Poverty, sexual experience and HIV vulnerability risks: evidence from Addis Ababa, Ethiopia. J Biosoc Sci. 2012;44(6):677–701.

    Article  PubMed  Google Scholar 

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Acknowledgments

We would like to thank all patients at the health facilities included in this study. We want to acknowledge the efforts of the ICAP staff in-country and health facility staff for their commitment to confronting the HIV epidemic. We would also like to thank Dr. David G. Ostrow for his consultative contributions to this study. This work was supported by a research grant from the National Institute of Mental Health (Grant No. R01MH089831). All the clinics included in this analysis received support from ICAP at Columbia University through funding from the President’s Emergency Plan for AIDS Relief.

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Correspondence to Quynh T. Vo.

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Vo, Q.T., Hoffman, S., Nash, D. et al. Gender Differences and Psychosocial Factors Associated with Quality of Life Among ART Initiators in Oromia, Ethiopia. AIDS Behav 20, 1682–1691 (2016). https://doi.org/10.1007/s10461-016-1396-8

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