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Improvements in Depression and Changes in Fatigue: Results from the SLAM DUNC Depression Treatment Trial

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Abstract

Fatigue and depression are common co-morbid conditions among people with HIV infection. We analyzed a population of HIV-infected adults with depression, who were enrolled in a depression treatment trial, to examine the extent to which improvements in depression over time were associated with improvements in HIV-related fatigue. Data for this analysis come from a randomized controlled trial to evaluate the effectiveness of improved depression treatment on antiretroviral adherence. Fatigue was measured using the HIV-Related Fatigue Scale, and depressive symptoms were measured with the Hamilton Depression Rating Scale. Participants (n = 234) were on average nearly 44 years of age and predominantly male, black or African American, and unemployed. Individuals who experienced stronger depression response (i.e., greater improvement in depression score) had larger decreases in fatigue. However, even among those who demonstrated a full depression response, nearly three-quarters continued to have either moderate or severe fatigue at 6 and 12 months.

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Author contributions

Study concept and design: Barroso, Gaynes, Quinlivan, Heine, Thielman, Pence. Statistical analysis: Bengtson, Pence. Drafting of the manuscript: Barroso, Bengtson, Pence. Critical revision of the manuscript for important intellectual content: All authors. The senior author (BWP) had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Authors and Affiliations

  1. College of Nursing, Medical University of South Carolina, Charleston, SC, USA

    Julie Barroso

  2. Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, USA

    Angela M. Bengtson & Brian W. Pence

  3. Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, USA

    Bradley N. Gaynes

  4. School of Nursing, University of Alabama-Birmingham, Birmingham, USA

    Teena McGuinness

  5. Division of Infectious Diseases, University of North Carolina-Chapel Hill, Chapel Hill, USA

    Evelyn B. Quinlivan & Amy Heine

  6. Warren-Vance Community Health Center, Henderson, NC, USA

    Michelle Ogle

  7. Division of Infectious Diseases, Duke University, Durham, USA

    Nathan M. Thielman

Authors
  1. Julie Barroso
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  2. Angela M. Bengtson
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  3. Bradley N. Gaynes
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  4. Teena McGuinness
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  5. Evelyn B. Quinlivan
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  6. Michelle Ogle
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  7. Amy Heine
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  8. Nathan M. Thielman
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  9. Brian W. Pence
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Corresponding author

Correspondence to Julie Barroso.

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The authors report no conflicts of interest.

Funding/Support

This work was supported by grant R01-MH086362 from the National Institute of Mental Health and the National Institute for Nursing Research, National Institutes of Health, Bethesda, MD, USA. Support for the design and conduct of the study was also provided by the NIH-funded Centers for AIDS Research at the University of North Carolina at Chapel Hill, Duke University, and the University of Alabama at Birmingham (P30-AI50410, P30-AI064518, and P30-AI027767). AB was also supported by T32-AI007001 of the NIH.

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The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIMH or the NIH.

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Barroso, J., Bengtson, A.M., Gaynes, B.N. et al. Improvements in Depression and Changes in Fatigue: Results from the SLAM DUNC Depression Treatment Trial. AIDS Behav 20, 235–242 (2016). https://doi.org/10.1007/s10461-015-1242-4

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  • DOI: https://doi.org/10.1007/s10461-015-1242-4

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