AIDS and Behavior

, Volume 18, Issue 12, pp 2409–2422 | Cite as

ACT2 Peer-Driven Intervention Increases Enrollment into HIV/AIDS Medical Studies Among African Americans/Blacks and Hispanics: A Cluster Randomized Controlled Trial

  • Marya Gwadz
  • Charles M. Cleland
  • Mindy Belkin
  • Amanda Ritchie
  • Noelle Leonard
  • Marion Riedel
  • Angela Banfield
  • Pablo Colon
  • Vanessa Elharrar
  • Jonathan Kagan
  • Donna Mildvan
  • ACT2 Collaborative Research Team
Original Paper


African American/Black and Hispanic persons living with HIV/AIDS (“AABH-PLHA”) are under-represented in HIV/AIDS medical studies (HAMS). This paper evaluates the efficacy of a social/behavioral intervention to increase rates of screening for and enrollment into HAMS in these populations. Participants (N = 540) were enrolled into a cluster randomized controlled trial of an intervention designed to overcome multi-level barriers to HAMS. Primary endpoints were rates of screening for and enrollment into therapeutic/treatment-oriented and observational studies. Intervention arm participants were 30 times more likely to be screened than controls (49.3 % vs. 3.7 %; p < .001). Half (55.5 %) of those screened were eligible for HAMS, primarily observational studies. Nine out of ten found eligible enrolled (91.7 %), almost all into observational studies (95.2 %), compared to no enrollments among controls. Achieving appropriate representation of AABH-PLHA in HAMS necessitates modification of study inclusion criteria to increase the proportion found eligible for therapeutic HAMS, in addition to social/behavioral interventions.


Clinical trials HIV/AIDS African American Black Hispanic Minority Motivational Interviewing Health care disparities 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Marya Gwadz
    • 1
  • Charles M. Cleland
    • 1
  • Mindy Belkin
    • 1
  • Amanda Ritchie
    • 1
  • Noelle Leonard
    • 1
  • Marion Riedel
    • 2
  • Angela Banfield
    • 1
  • Pablo Colon
    • 1
  • Vanessa Elharrar
    • 3
  • Jonathan Kagan
    • 3
  • Donna Mildvan
    • 4
  • ACT2 Collaborative Research Team
  1. 1.Center for Drug Use and HIV ResearchNew York University College of NursingNew YorkUSA
  2. 2.School of Social WorkColumbia UniversityNew YorkUSA
  3. 3.National Institute of Allergy & Infectious Diseases National Institutes of HealthBethesdaUSA
  4. 4.Division of Infectious DiseasesMt. Sinai Beth Israel Medical CenterNew YorkUSA

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