Skip to main content
SpringerLink
Log in

Pilot Controlled Trial of the Adherence Readiness Program: An Intervention to Assess and Sustain HIV Antiretroviral Adherence Readiness

  • Brief Report
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

Abstract

To pilot the adherence readiness program, 60 patients planning to start HIV antiretrovirals were assigned to usual care (n = 31) or the intervention (n = 29), of whom 54 started antiretrovirals and were followed for up to 24 weeks. At week 24, the intervention had a large effect (50.0 % vs. 16.7 %, d = 0.75) on optimal dose-timing (85+ % doses taken on time) and small effect (54.2 % vs. 43.3 %, d = 0.22) on optimal dose-taking (85+ % doses taken) electronically monitored adherence, and medium effect on undetectable viral load (62 % 0.5 % vs. 43.4 %, d = 0.41), compared to usual care. These intervention benefits on adherence and viral suppression warrant further investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bangsberg DR, Acosta EP, Gupta R, et al. Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness. AIDS. 2006;20(2):223–31.

    Article  PubMed  CAS  Google Scholar 

  2. Bouton MEM. A learning theory perspective on lapse, relapse, and the maintenance of behavior change. Health Psychol. 2000;19(1):57–63.

    Article  PubMed  CAS  Google Scholar 

  3. Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.

    Article  PubMed  CAS  Google Scholar 

  4. Thompson MA, Aberg JA, Hoy JF, et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA. 2012;308(4):387–402.

    Article  PubMed  CAS  Google Scholar 

  5. Bangsberg DR, Hecht FM, Clague H, et al. Provider assessment of adherence to HIV antiretroviral therapy. J Acquir Immune Defic Syndr. 2001;26(5):435–42.

    PubMed  CAS  Google Scholar 

  6. Grimes RM, Grimes DE. Readiness, trust, and adherence: a clinical perspective. J Int Assoc Physicians AIDS Care. 2012 Aug 17; ahead of print.

  7. Simoni JM, Pearson CR, Pantalone DW, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: a meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr. 2006;43(1):S23–35.

    Article  PubMed  Google Scholar 

  8. Amico KR, Harman JJ, Johnson BT. Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr. 2006;41(3):285–97.

    Article  PubMed  Google Scholar 

  9. Fisher JD, Fisher WA, Misovich SJ, Kimble DL, Malloy TE. Changing AIDS risk behavior: effects of an intervention emphasizing AIDS risk reduction information, motivation, and behavioral skills in a college student population. Health Psychol. 1996;15(2):114–23.

    Article  PubMed  CAS  Google Scholar 

  10. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.

    Article  PubMed  CAS  Google Scholar 

  11. Bangsberg DR, Perry S, Charlebois ED, et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS. 2001;15(9):1181–3.

    Article  PubMed  CAS  Google Scholar 

  12. Gill C, Sabin L, Hamer D, et al.(2010) Importance of dose timing to achieving undetectable viral loads. AIDS Behav. 8 Jan 2010;14(4):785–793.

    Google Scholar 

Download references

Acknowledgments

The research was supported by Grant R34MH085534 from the National Institute of Mental Health. The content of this paper does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health.

Author information

Authors and Affiliations

  1. RAND Corporation, 1776 Main St., Santa Monica, CA, 90407, USA

    Glenn J. Wagner

  2. Living Hope Clinical Foundation, Long Beach, CA, USA

    Paul Lovely & Stefan Schneider

Authors
  1. Glenn J. Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul Lovely
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stefan Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Glenn J. Wagner.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 126 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wagner, G.J., Lovely, P. & Schneider, S. Pilot Controlled Trial of the Adherence Readiness Program: An Intervention to Assess and Sustain HIV Antiretroviral Adherence Readiness. AIDS Behav 17, 3059–3065 (2013). https://doi.org/10.1007/s10461-013-0550-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-013-0550-9

Keywords

Search

Navigation