AIDS and Behavior

, Volume 16, Issue 5, pp 1276–1285 | Cite as

Efficacy of an Intervention for Families Living with HIV in Thailand: A Randomized Controlled Trial

  • Li LiEmail author
  • Li-Jung Liang
  • Sung-Jae Lee
  • Sopon Iamsirithaworn
  • Dai Wan
  • Mary Jane Rotheram-Borus
Original Paper


This study evaluates the efficacy of an intervention for persons living with HIV (PLH) and their family members in Thailand. A randomized controlled trial of 813 PLH and family members was carried out at four district hospitals in Thailand. Participants completed Computer Assisted Personal Interview assessments at baseline, 6, 12, 18, and 24 months. The primary outcome was quality of life (QoL); other measures included depressive symptoms and family functioning. Relative to the standard care condition, the intervention group reported significantly improved QoL at 6 months (P = 0.0014). When the intervention efficacy was stratified by baseline depressive symptoms (low vs. high), intervention efficacy was observed only among those with low depressive symptoms. Study findings suggest that the intervention was more efficacious for participants with less depressive symptoms and better family functioning. Extensive interventions may be optimal for those who have the capacity to learn the tools and skills.


HIV/AIDS Quality of life Depressive symptoms Family functioning Thailand 


Este estudio evalúa la eficacia de una intervención para las personas que viven con el VIH (PLH) y sus familiares en Tailandia. Un ensayo controlado y aleatorio de 813 miembros del PLH y sus familiares se llevó a cabo en cuatro hospitales de distrito en Tailandia. Los participantes completaron las evaluaciones de la Entrevista Personal y Asistida por Computadora (CAPI) al inicio del estudio y también después de 6, 12, 18 y 24 meses. El resultado primario fue la calidad de vida (QoL); otras medidas incluyeron síntomas depresivos y el funcionamiento familiar. Relacionada a la condición de la atención estándar, el grupo de intervención reportó que la calidad de vida había mejorado significativamente a los 6 meses (P = 0,0014). Cuando la eficacia de la intervención se estratificó por los síntomas depresivos de base (bajos v. altos), la eficacia de la intervención se observó sólo entre las personas con síntomas depresivos bajos. Los resultados del estudio sugieren que la intervención fue más eficaz para los participantes con menos síntomas depresivos y el mejor funcionamiento familiar. Las intervenciones extensas pueden ser óptimas para los que tienen la capacidad de aprender las herramientas y las habilidades.



This paper was completed with the support of the National Institute of Nursing Research at the National Institute of Health (R01-NR009922) and the National Institute of Mental Health (NIMH K01MH085503).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Li Li
    • 1
    Email author
  • Li-Jung Liang
    • 2
  • Sung-Jae Lee
    • 1
  • Sopon Iamsirithaworn
    • 3
  • Dai Wan
    • 1
  • Mary Jane Rotheram-Borus
    • 1
  1. 1.Semel Institute for Neuroscience and Human Behavior, Center for Community HealthUniversity of California at Los AngelesLos AngelesUSA
  2. 2.Department of Medicine Statistics CoreUniversity of California at Los AngelesLos AngelesUSA
  3. 3.Bureau of EpidemiologyThai Ministry of Public HealthBangkokThailand

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