AIDS and Behavior

, Volume 15, Issue 7, pp 1397–1409 | Cite as

Once Daily Dosing Improves Adherence to Antiretroviral Therapy

  • Janet Raboud
  • Maggie Li
  • Sharon Walmsley
  • Curtis Cooper
  • Sandra Blitz
  • Ahmed M. Bayoumi
  • Sean Rourke
  • Sergio Rueda
  • Anita Rachlis
  • Nicole Mittmann
  • Marek Smieja
  • Evan Collins
  • Mona R. Loutfy
Original Paper


We studied the association of once-daily dosing with self-reported adherence among participants of the Ontario Cohort Study who were currently taking ART and who had completed a 90-min interviewer-administered questionnaire. Suboptimal adherence was defined as missing ≥1 dose of ART in the 4 days prior to the interview. Participants (n = 779) were 85% male, 69% men having sex with men, 67% white, median age 48 years (IQR 42–54), median years of ART 9 (IQR 5–13) and median CD4 count 463 cells/mm3 (IQR 320–638). Fifteen percent of participants reported suboptimal adherence in the 4 days prior to the interview. In a multivariable logistic regression model, participants on once daily regimens were half as likely to miss a dose during the 4 days prior to the interview. Other independent correlates of suboptimal adherence were younger age, lower positive social interaction and increased frequency of consuming > 6 alcoholic drinks on one occasion.


Adherence HIV Antiretroviral therapy Once-daily dosing 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Janet Raboud
    • 1
    • 2
  • Maggie Li
    • 1
  • Sharon Walmsley
    • 1
    • 3
  • Curtis Cooper
    • 4
  • Sandra Blitz
    • 1
  • Ahmed M. Bayoumi
    • 3
    • 5
  • Sean Rourke
    • 3
    • 5
    • 6
    • 7
  • Sergio Rueda
    • 5
    • 6
  • Anita Rachlis
    • 3
    • 8
  • Nicole Mittmann
    • 9
  • Marek Smieja
    • 10
  • Evan Collins
    • 1
    • 7
  • Mona R. Loutfy
    • 3
    • 11
    • 12
  1. 1.Division of Infectious DiseaseUniversity Health NetworkTorontoCanada
  2. 2.Dalla Lana School of Public HealthUniversity of TorontoTorontoCanada
  3. 3.Departments of Medicine and Health PolicyManagement and Evaluation, University of TorontoTorontoCanada
  4. 4.The University of Ottawa, The Ottawa Hospital Division of Infectious DiseasesOttawaCanada
  5. 5.Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute and Division of General Internal MedicineSt. Michael’s HospitalTorontoCanada
  6. 6.Ontario HIV Treatment NetworkTorontoCanada
  7. 7.Department of PsychiatryUniversity of TorontoTorontoCanada
  8. 8.Division of Infectious DiseasesSunnybrook Health Sciences CentreTorontoCanada
  9. 9.Health Outcomes and Pharmaco Economics (HOPE) Research CentreSunnybrook Health Sciences CentreTorontoCanada
  10. 10.Department of Pathology and Molecular MedicineMcMaster UniversityHamiltonCanada
  11. 11.Maple Leaf Medical ClinicTorontoCanada
  12. 12.Women’s College Research InstituteWomen’s College HospitalTorontoCanada

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