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Gender and Other Psychosocial Factors as Predictors of Adherence to Highly Active Antiretroviral Therapy (HAART) in Adults with Comorbid HIV/AIDS, Psychiatric and Substance-related Disorder

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Abstract

This study assessed adherence to HAART among 67 HIV-infected adults, and the degree to which gender and psychological factors—including depression, drug and alcohol use, quality of life, and medication side effects—influenced adherence. Although overall adherence was greater than rates reported in similar studies, no significant difference in adherence was observed between men and women in the present sample. Medication side effects were a significant predictor of non-adherence in the sample at large and among women in particular, while alcohol dependence was a significant predictor of non-adherence only in women. Possible explanations are explored.

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Acknowledgements

This work was supported by the HIV/AIDS Treatment Adherence, Health Outcomes and Cost Study, a collaboration of six Federal entities within the U.S. Department of Health and Human Services (DHHS): The Center for Mental Health Services (CMHS), which had the lead administrative responsibility, and the Center for Substance Abuse Treatment (CSAT), both components of the Substance Abuse and Mental Health Services Administration (SAMHSA); the HIV/AIDS Bureau of the Health Resources and Services Administration (HRSA); the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), all parts of the National Institutes of Health (NIH). The content of this publication does not necessarily reflect the views or policies of these or any other agencies of the DHHS.

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Correspondence to Allison J. Applebaum.

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Applebaum, A.J., Richardson, M.A., Brady, S.M. et al. Gender and Other Psychosocial Factors as Predictors of Adherence to Highly Active Antiretroviral Therapy (HAART) in Adults with Comorbid HIV/AIDS, Psychiatric and Substance-related Disorder. AIDS Behav 13, 60–65 (2009). https://doi.org/10.1007/s10461-008-9441-x

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