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Nectins and Nectin-like molecules drive vascular development and barrier function

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A Correction to this article was published on 29 April 2023

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Abstract

Angiogenesis, barriergenesis, and immune cell migration are all key physiological events that are dependent on the functional characteristics of the vascular endothelium. The protein family of Nectins and Nectin-like molecules (Necls) is a group of cell adhesion molecules that are widely expressed by different endothelial cell types. The family includes four Nectins (Nectin-1 to -4) and five Necls (Necl-1 to -5) that either interact with each other by forming homo- and heterotypical interactions or bind to ligands expressed within the immune system. Nectin and Necl proteins are mainly described to play a role in cancer immunology and in the development of the nervous system. However, Nectins and Necls are underestimated players in the formation of blood vessels, their barrier properties, and in guiding transendothelial migration of leukocytes. This review summarizes their role in supporting the endothelial barrier through their function in angiogenesis, cell–cell junction formation, and immune cell migration. In addition, this review provides a detailed overview of the expression patterns of Nectins and Necls in the vascular endothelium.

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Acknowledgements

This work was financially supported by grants from the Research Foundation of Flanders (FWO Vlaanderen), Bijzonder Onderzoeksfonds (BOF) UHasselt, and Belgian Charcot Foundation.

Funding

Fonds Wetenschappelijk Onderzoek, Bijzonder Onderzoeksfonds UHasselt, Universiteit Hasselt, Vrije Universiteit Amsterdam, KU Leuven, and Belgian Charcot Foundation

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Authors and Affiliations

  1. Department of Immunology and Infection, UHasselt, Biomedical Research Institute (BIOMED), Diepenbeek, Belgium

    Doryssa Hermans & Bieke Broux

  2. Molecular Cell Biology and Immunology, MS Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands

    Carla Rodriguez-Mogeda & Helga E. de Vries

  3. Department of Cardio & Organ Systems, UHasselt, Biomedical Research Institute (BIOMED), Diepenbeek, Belgium

    Hannelore Kemps & Annelies Bronckaers

  4. KU Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Leuven, Belgium

    Hannelore Kemps

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  5. Helga E. de Vries
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Contributions

Conceptualization: DH; Writing of the original draft: DH, CRM, and HK; Literature search: DH, CRM, and HK; Visualization: DH; Writing, reviewing, and editing of the manuscript: BB, AB, and HEdV. All authors have read and agreed to the published version of the manuscript.

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Hermans, D., Rodriguez-Mogeda, C., Kemps, H. et al. Nectins and Nectin-like molecules drive vascular development and barrier function. Angiogenesis 26, 349–362 (2023). https://doi.org/10.1007/s10456-023-09871-y

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