Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, Jonigk D, Chocron R, Pier GB, Gendron N, Pons S, Diehl JL, Margadant C, Guerin C, Huijbers EJM, Philippe A, Chapuis N, Nowak-Sliwinska P, Karagiannidis C, Sanchez O, Kumpers P, Skurnik D, Randi AM, Griffioen AW (2021) COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis. https://doi.org/10.1007/s10456-021-09805-6
Article
PubMed
PubMed Central
Google Scholar
Goldsmith CS, Miller SE, Martines RB, Bullock HA, Zaki SR (2020) Electron microscopy of SARS-CoV-2: a challenging task. The Lancet 395(10238):e99. https://doi.org/10.1016/S0140-6736(20)31188-0
CAS
Article
Google Scholar
McCracken IR, Saginc G, He L, Huseynov A, Daniels A, Fletcher S, Peghaire C, Kalna V, Andaloussi-Mäe M, Muhl L, Craig NM, Griffiths SJ, Haas JG, Tait-Burkard C, Lendahl U, Birdsey GM, Betsholtz C, Noseda M, Baker AH, Randi AM (2021) Lack of evidence of ACE2 expression and replicative infection by SARSCoV-2 in human endothelial cells. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.120.052824
Article
PubMed
PubMed Central
Google Scholar
Bradley BT, Maioli H, Johnston R, Chaudhry I, Fink SL, Xu H, Najafian B, Deutsch G, Lacy JM, Williams T, Yarid N, Marshall DA (2020) Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. Lancet 396(10247):320–332. https://doi.org/10.1016/S0140-6736(20)31305-2
CAS
Article
PubMed
PubMed Central
Google Scholar
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet 395(10223):497–506
CAS
Article
Google Scholar
Smadja DM, Guerin CL, Chocron R, Yatim N, Boussier J, Gendron N, Khider L, Hadjadj J, Goudot G, Debuc B, Juvin P, Hauw-Berlemont C, Augy J-L, Peron N, Messas E, Planquette B, Sanchez O, Charbit B, Gaussem P, Duffy D, Terrier B, Mirault T, Diehl J-L (2020) Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Angiogenesis 23(4):611–620. https://doi.org/10.1007/s10456-020-09730-0
CAS
Article
PubMed
Google Scholar
Bermejo-Martin JF, Gonzalez-Rivera M, Almansa R, Micheloud D, Tedim AP, Dominguez-Gil M, Resino S, Martin-Fernandez M, Ryan Murua P, Perez-Garcia F, Tamayo L, Lopez-Izquierdo R, Bustamante E, Aldecoa C, Gomez JM, Rico-Feijoo J, Orduna A, Mendez R, Fernandez Natal I, Megias G, Gonzalez-Estecha M, Carriedo D, Doncel C, Jorge N, Ortega A, de la Fuente A, Del Campo F, Fernandez-Ratero JA, Trapiello W, Gonzalez-Jimenez P, Ruiz G, Kelvin AA, Ostadgavahi AT, Oneizat R, Ruiz LM, Miguens I, Gargallo E, Munoz I, Pelegrin S, Martin S, Garcia Olivares P, Cedeno JA, Ruiz Albi T, Puertas C, Berezo JA, Renedo G, Herran R, Bustamante-Munguira J, Enriquez P, Cicuendez R, Blanco J, Abadia J, Gomez Barquero J, Mamolar N, Blanca-Lopez N, Valdivia LJ, Fernandez Caso B, Mantecon MA, Motos A, Fernandez-Barat L, Ferrer R, Barbe F, Torres A, Menendez R, Eiros JM, Kelvin DJ (2020) Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Crit Care 24(1):691. https://doi.org/10.1186/s13054-020-03398-0
Article
PubMed
PubMed Central
Google Scholar
Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ (2020) Circulating markers of angiogenesis and endotheliopathy in COVID-19. Pulm Circ 10(4):2045894020966547
Article
Google Scholar
Rovas A, Osiaevi I, Buscher K, Sackarnd J, Tepasse PR, Fobker M, Kuhn J, Braune S, Gobel U, Tholking G, Groschel A, Pavenstadt H, Vink H, Kumpers P (2020) Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. https://doi.org/10.1007/s10456-020-09753-7
Article
PubMed
PubMed Central
Google Scholar
Smadja DM, Philippe A, Bory O, Gendron N, Beauvais A, Gruest M, Peron N, Khider L, Guerin CL, Goudot G, Levavasseur F, Duchemin J, Pene F, Cheurfa C, Szwebel TA, Sourdeau E, Planquette B, Hauw-Berlemont C, Hermann B, Gaussem P, Samama CM, Mirault T, Terrier B, Sanchez O, Rance B, Fontenay M, Diehl JL, Chocron R (2021) Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality. J Thromb Haemost. https://doi.org/10.1111/jth.15339
Article
PubMed
PubMed Central
Google Scholar
Rauch A, Dupont A, Goutay J, Caplan M, Staessens S, Moussa M, Jeanpierre E, Corseaux D, Lefevre G, Lassalle F, Faure K, Lambert M, Duhamel A, Labreuche J, Garrigue D, De Meyer SF, Staels B, Van Belle E, Vincent F, Kipnis E, Lenting PJ, Poissy J, Susen S, Lille CRN, Members of the LSC (2020) Endotheliopathy is induced by plasma from critically ill patients and associated with organ failure in severe COVID-19. Circulation 142(19):1881–1884. https://doi.org/10.1161/CIRCULATIONAHA.120.050907
CAS
Article
PubMed
PubMed Central
Google Scholar
Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reiss IKM, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin DS, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL (2018) Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine. Intensive Care Med 44(3):281–299. https://doi.org/10.1007/s00134-018-5070-7
Article
PubMed
Google Scholar
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801–810. https://doi.org/10.1001/jama.2016.0287
CAS
Article
PubMed
PubMed Central
Google Scholar
Drost CC, Rovas A, Kusche-Vihrog K, Van Slyke P, Kim H, Hoang VC, Maynes JT, Wennmann DO, Pavenstadt H, Linke W, Lukasz A, Hesse B, Kumpers P (2019) Tie2 activation promotes protection and reconstitution of the endothelial glycocalyx in human sepsis. Thromb Haemost 119(11):1827–1838. https://doi.org/10.1055/s-0039-1695768
Article
PubMed
Google Scholar
Rovas A, Seidel LM, Vink H, Pohlkotter T, Pavenstadt H, Ertmer C, Hessler M, Kumpers P (2019) Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care 23(1):260. https://doi.org/10.1186/s13054-019-2542-2
Article
PubMed
PubMed Central
Google Scholar
Rovas A, Lukasz AH, Vink H, Urban M, Sackarnd J, Pavenstadt H, Kumpers P (2018) Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit: the GlycoNurse study. Scand J Trauma Resusc Emerg Med 26(1):16. https://doi.org/10.1186/s13049-018-0483-4
Article
PubMed
PubMed Central
Google Scholar
Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstadt H, Vink H, Kumpers P (2021) Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. Crit Care 25(1):112. https://doi.org/10.1186/s13054-021-03520-w
Article
PubMed
PubMed Central
Google Scholar
Diez-Silva M, Dao M, Han J, Lim CT, Suresh S (2010) Shape and biomechanical characteristics of human red blood cells in health and disease. MRS Bull 35(5):382–388. https://doi.org/10.1557/mrs2010.571
CAS
Article
PubMed
PubMed Central
Google Scholar
Assarsson E, Lundberg M, Holmquist G, Bjorkesten J, Thorsen SB, Ekman D, Eriksson A, Rennel Dickens E, Ohlsson S, Edfeldt G, Andersson AC, Lindstedt P, Stenvang J, Gullberg M, Fredriksson S (2014) Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLoS ONE 9(4):e95192. https://doi.org/10.1371/journal.pone.0095192
CAS
Article
PubMed
PubMed Central
Google Scholar
Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Gerszten RE, Heimberg GS, Hoover PJ, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M, Smillie CS, Waghray A, Wood TE, Zajac AS, Jennings LL, Grundberg I, Bhattacharyya RP, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Goldberg MB (2021) Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. Cell Rep Med 2(5):100287. https://doi.org/10.1016/j.xcrm.2021.100287
Article
PubMed
PubMed Central
Google Scholar
Metsalu T, Vilo J (2015) ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Nucleic Acids Res 43(W1):W566-570. https://doi.org/10.1093/nar/gkv468
CAS
Article
PubMed
PubMed Central
Google Scholar
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10(1):1523. https://doi.org/10.1038/s41467-019-09234-6
CAS
Article
PubMed
PubMed Central
Google Scholar
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498–2504. https://doi.org/10.1101/gr.1239303
CAS
Article
PubMed
PubMed Central
Google Scholar
Del Valle DM, Kim-Schulze S, Huang HH, Beckmann ND, Nirenberg S, Wang B, Lavin Y, Swartz TH, Madduri D, Stock A, Marron TU, Xie H, Patel M, Tuballes K, Van Oekelen O, Rahman A, Kovatch P, Aberg JA, Schadt E, Jagannath S, Mazumdar M, Charney AW, Firpo-Betancourt A, Mendu DR, Jhang J, Reich D, Sigel K, Cordon-Cardo C, Feldmann M, Parekh S, Merad M, Gnjatic S (2020) An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat Med 26(10):1636–1643. https://doi.org/10.1038/s41591-020-1051-9
CAS
Article
PubMed
PubMed Central
Google Scholar
Wilson JG, Simpson LJ, Ferreira AM, Rustagi A, Roque J, Asuni A, Ranganath T, Grant PM, Subramanian A, Rosenberg-Hasson Y, Maecker HT, Holmes SP, Levitt JE, Blish CA, Rogers AJ (2020) Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis. JCI Insight. https://doi.org/10.1172/jci.insight.140289
Article
PubMed
PubMed Central
Google Scholar
Dong X, Wang C, Liu X, Gao W, Bai X, Li Z (2020) Lessons learned comparing immune system alterations of bacterial sepsis and SARS-CoV-2 sepsis. Front Immunol 11:598404. https://doi.org/10.3389/fimmu.2020.598404
CAS
Article
PubMed
PubMed Central
Google Scholar
Kox M, Frenzel T, Schouten J, van de Veerdonk FL, Koenen H, Pickkers P, Group obotRCIC-s (2020) COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients. Crit Care 24(1):263. https://doi.org/10.1186/s13054-020-02896-5
Article
PubMed
PubMed Central
Google Scholar
de Roquetaillade C, Mansouri S, Brumpt C, Neuwirth M, Voicu S, Le Dorze M, Fontaine C, Barthelemy R, Gayat E, Megarbane B, Mebazaa A, Chousterman BG (2021) Comparison of circulating immune cells profiles and kinetics between coronavirus disease 2019 and bacterial sepsis. Crit Care Med. https://doi.org/10.1097/CCM.0000000000005088
Article
PubMed
Google Scholar
Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS (2020) Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med 8(12):1233–1244. https://doi.org/10.1016/S2213-2600(20)30404-5
CAS
Article
PubMed
PubMed Central
Google Scholar
Yu J, Wang Y, Lin S, Jiang L, Sang L, Zheng X, Zhong M (2021) Severe COVID-19 has a distinct phenotype from bacterial sepsis: a retrospective cohort study in deceased patients. Ann Transl Med 9(13):1054. https://doi.org/10.21037/atm-21-1291
CAS
Article
PubMed
PubMed Central
Google Scholar
Perschinka F, Mayerhofer T, Lehner GF, Hasslacher J, Klein SJ, Joannidis M (2022) Immunologic response in bacterial sepsis is different from that in COVID-19 sepsis. Infection. https://doi.org/10.1007/s15010-022-01803-0
Article
PubMed
PubMed Central
Google Scholar
Health NIo (2022) Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. https://covid19treatmentguidelines.nih.gov/ Accessed 7 May 2022
Shinjo K, Tsuda S, Hayami T, Asahi T, Kawaharada H (1989) Increase in permeability of human endothelial cell monolayer by recombinant human lymphotoxin. Biochem Biophys Res Commun 162(3):1431–1437. https://doi.org/10.1016/0006-291x(89)90834-6
CAS
Article
PubMed
Google Scholar
Wassmer SC, Combes V, Candal FJ, Juhan-Vague I, Grau GE (2006) Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infect Immun 74(1):645–653. https://doi.org/10.1128/IAI.74.1.645-653.2006
CAS
Article
PubMed
PubMed Central
Google Scholar
Meng SS, Guo FM, Zhang XW, Chang W, Peng F, Qiu HB, Yang Y (2019) mTOR/STAT-3 pathway mediates mesenchymal stem cell-secreted hepatocyte growth factor protective effects against lipopolysaccharide-induced vascular endothelial barrier dysfunction and apoptosis. J Cell Biochem 120(3):3637–3650. https://doi.org/10.1002/jcb.27642
CAS
Article
PubMed
Google Scholar
Liu F, Schaphorst KL, Verin AD, Jacobs K, Birukova A, Day RM, Bogatcheva N, Bottaro DP, Garcia JG (2002) Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta. FASEB J 16(9):950–962. https://doi.org/10.1096/fj.01-0870com
CAS
Article
PubMed
Google Scholar
Langford BJ, So M, Raybardhan S, Leung V, Westwood D, MacFadden DR, Soucy JR, Daneman N (2020) Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect 26(12):1622–1629. https://doi.org/10.1016/j.cmi.2020.07.016
CAS
Article
PubMed
PubMed Central
Google Scholar
Adler H, Ball R, Fisher M, Mortimer K, Vardhan MS (2020) Low rate of bacterial co-infection in patients with COVID-19. Lancet Microbe 1(2):e62. https://doi.org/10.1016/S2666-5247(20)30036-7
CAS
Article
PubMed
PubMed Central
Google Scholar