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Opposite response of lung adenocarcinoma and its choroidal metastases upon ramucirumab plus docetaxel therapy after immunotherapy: a case report

Abstract

We report a unique case of advanced non-small cell lung cancer that exhibited the opposite response to its unilateral choroidal metastases upon ramucirumab plus docetaxel treatment. A combination of cisplatin, pemetrexed, and pembrolizumab was administered as first-line treatment, resulting in shrinkage of all the lesions. However, although the patient was continued on a course of pembrolizumab, all the lesions had recurred approximately two months later. Ramucirumab plus docetaxel, administered as sequential treatment, resulted in maintained shrinkage of the choroidal lesions, yet all the other lesions progressed. Ramucirumab may be a suitable therapy for choroidal metastases, especially if administered immediately after immunotherapy.

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References

  1. Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE (1997) Survey of 520 eyes with uveal metastases. Ophthalmology 104(8):1265–1276. https://doi.org/10.1016/s0161-6420(97)30148-1

    CAS  Article  PubMed  Google Scholar 

  2. Mathis T, Jardel P, Loria O et al (2019) New concepts in the diagnosis and management of choroidal metastases. Prog Retin Eye Res 68:144–176. https://doi.org/10.1016/j.preteyeres.2018.09.003

    Article  PubMed  Google Scholar 

  3. Huinen ZR, Huijbers EJM, van Beijnum JR, Nowak-Sliwinska P, Griffioen AW (2021) Anti-angiogenic agents—overcoming tumour endothelial cell anergy and improving immunotherapy outcomes. Nat Rev Clin Oncol 18(8):527–540. https://doi.org/10.1038/s41571-021-00496-y

    Article  PubMed  Google Scholar 

  4. Amselem L, Cervera E, Díaz-Llopis M et al (2007) Intravitreal bevacizumab (Avastin) for choroidal metastasis secondary to breast carcinoma: short-term follow-up. Eye 21(4):566–567. https://doi.org/10.1038/sj.eye.6702647

    CAS  Article  PubMed  Google Scholar 

  5. Tozuka T, Kitazono S, Sakamoto H et al (2020) Addition of ramucirumab enhances docetaxel efficacy in patients who had received anti-PD-1/PD-L1 treatment. Lung Cancer 144:71–75. https://doi.org/10.1016/j.lungcan.2020.04.021

    Article  PubMed  Google Scholar 

  6. Brueckl WM, Reck M, Rittmeyer A et al (2020) Efficacy of docetaxel plus ramucirumab as palliative third-line therapy following second-line immune-checkpoint-inhibitor treatment in patients with non-small-cell lung cancer stage IV. Clin Med Insights Oncol 14:1179554920951358. https://doi.org/10.1177/1179554920951358

    Article  PubMed  PubMed Central  Google Scholar 

  7. Li X, Liang Y, Wang J, Hu Z, Yuan ZL, Xie P (2021) Pembrolizumab for choroidal metastases from non-small cell lung cancer: a case report and literature review. Hum Vaccin Immunother. https://doi.org/10.1080/21645515.2021.1885282

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Takayuki Shiroyama.

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Matsumoto, K., Shiroyama, T., Hashida, N. et al. Opposite response of lung adenocarcinoma and its choroidal metastases upon ramucirumab plus docetaxel therapy after immunotherapy: a case report. Angiogenesis 25, 147–149 (2022). https://doi.org/10.1007/s10456-021-09820-7

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  • DOI: https://doi.org/10.1007/s10456-021-09820-7

Keywords

  • Lung adenocarcinoma
  • Choroidal metastasis
  • Ramucirumab
  • Docetaxel
  • Case report