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Embryonic circulating endothelial progenitor cells

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Abstract

The development of vascular system in vertebrates has been traditionally explained by early vasculogenic assembly of angioblasts followed by angiogenic outgrowth of pre-existing vessels. The discovery of adult endothelial progenitor cells (Asahara et al. in Science 275(5302):964–967, 1997) challenged this view, since postnatal vascular growth could be accomplished by recruitment of circulating cells with the ability to differentiate into endothelial cells. However, the existence of embryonic circulating endothelial progenitor cells and their actual contribution to vascular development is far less known. We review in this paper the literature concerning the features, origin and physiological functions of embryonic and foetal circulating endothelial progenitors. Our review includes the early (E7.5) progenitors isolated from yolk sac, the hematovascular progenitors identified in the foetal liver, the yolk sac-derived erythro-myeloid progenitors, circulating hematopoietic cells from the G2-GATA4 lineage and the endothelial colony-forming cells isolated from the placenta and umbilical cord blood. We highlight the need of further characterization of these populations and the relationships between them.

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Funding

This work was supported by the Spanish Ministry of Science, Innovation and Universities under Grants BFU2017-83907-P, Instituto de Salud Carlos III-TERCEL network under Grant RD16/0011/0030; Consejería de Salud and Consejería de Economía y Conocimiento, Junta de Andalucía, under Grants PC0066‐2017/0034 and UMA18-FEDERJA-146, respectively.

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  1. Sandra Díaz del Moral and Silvia Barrena have contributed equally to this work.

Authors and Affiliations

  1. Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain

    Sandra Díaz del Moral, Silvia Barrena, Ramón Muñoz-Chápuli & Rita Carmona

  2. Andalusian Center for Nanomedicine and Biotechnology (BIONAND) and Institute of Biomedical Research of Málaga (IBIMA), Málaga, Spain

    Sandra Díaz del Moral, Silvia Barrena, Ramón Muñoz-Chápuli & Rita Carmona

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  1. Sandra Díaz del Moral
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Correspondence to Rita Carmona.

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Díaz del Moral, S., Barrena, S., Muñoz-Chápuli, R. et al. Embryonic circulating endothelial progenitor cells. Angiogenesis 23, 531–541 (2020). https://doi.org/10.1007/s10456-020-09732-y

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  • DOI: https://doi.org/10.1007/s10456-020-09732-y

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