, Volume 22, Issue 1, pp 15–36 | Cite as

Angiogenesis in pancreatic cancer: current research status and clinical implications

  • Shuo Li
  • Hua-Xiang Xu
  • Chun-Tao Wu
  • Wen-Quan Wang
  • Wei Jin
  • He-Li Gao
  • Hao Li
  • Shi-Rong Zhang
  • Jin-Zhi Xu
  • Zi-Hao Qi
  • Quan-Xing Ni
  • Xian-Jun YuEmail author
  • Liang LiuEmail author
Review Paper


Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year survival rate of < 5%. Angiogenesis, namely, the formation of new blood vessels from pre-existing vessels, is an important event in tumor growth and hematogenous metastasis. It is a dynamic and complex process involving multiple mechanisms and is regulated by various molecules. Inhibition of angiogenesis has been an established therapeutic strategy for many solid tumors. However, clinical outcomes are far from satisfying for pancreatic cancer patients receiving anti-angiogenic therapies. In this review, we summarize the current status of angiogenesis in pancreatic cancer research and explore the reasons for the poor efficacy of anti-angiogenic therapies, aiming to identify some potential therapeutic targets that may enhance the effectiveness of anti-angiogenic treatments.


Pancreatic cancer Angiogenesis Microvessel density Stromal components Anti-angiogenic therapy 



This work was supported by grants from the National Science Foundation for Distinguished Young Scholars of China (81625016), the National Natural Science Foundation of China (81472670, 81402397, and 81402398), the National Natural Science Foundation of Shanghai (14ZR1407600), and the “Yang-Fan” Plan for Young Scientists of Shanghai (14YF1401100).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Shuo Li
    • 1
    • 2
    • 3
    • 4
  • Hua-Xiang Xu
    • 1
    • 2
    • 3
    • 4
  • Chun-Tao Wu
    • 1
    • 2
    • 3
    • 4
  • Wen-Quan Wang
    • 1
    • 2
    • 3
    • 4
  • Wei Jin
    • 1
    • 2
    • 3
    • 4
  • He-Li Gao
    • 1
    • 2
    • 3
    • 4
  • Hao Li
    • 1
    • 2
    • 3
    • 4
  • Shi-Rong Zhang
    • 1
    • 2
    • 3
    • 4
  • Jin-Zhi Xu
    • 1
    • 2
    • 3
    • 4
  • Zi-Hao Qi
    • 1
    • 2
    • 3
    • 4
  • Quan-Xing Ni
    • 1
    • 2
    • 3
    • 4
  • Xian-Jun Yu
    • 1
    • 2
    • 3
    • 4
    Email author
  • Liang Liu
    • 1
    • 2
    • 3
    • 4
    Email author
  1. 1.Department of Pancreatic & Hepatobiliary SurgeryFudan University Shanghai Cancer CenterShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Shanghai Pancreatic Cancer InstituteShanghaiChina
  4. 4.Pancreatic Cancer InstituteFudan UniversityShanghaiChina

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