, Volume 21, Issue 1, pp 1–14 | Cite as

Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions

  • Sanaullah Sajib
  • Fatema Tuz Zahra
  • Michail S. Lionakis
  • Nadezhda A. GermanEmail author
  • Constantinos M. MikelisEmail author
Review Paper


Commensal microbiota inhabit all the mucosal surfaces of the human body. It plays significant roles during homeostatic conditions, and perturbations in numbers and/or products are associated with several pathological disorders. Angiogenesis, the process of new vessel formation, promotes embryonic development and critically modulates several biological processes during adulthood. Indeed, deregulated angiogenesis can induce or augment several pathological conditions. Accumulating evidence has implicated the angiogenic process in various microbiota-associated human diseases. Herein, we critically review diseases that are regulated by microbiota and are affected by angiogenesis, aiming to provide a broad understanding of how angiogenesis is involved and how microbiota regulate angiogenesis in microbiota-associated human conditions.


Microbiota Angiogenesis Gastritis Ulcer Cancer IBD 



MSL’s contribution was supported by the Division of Intramural Research, NIAID, NIH.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Sanaullah Sajib
    • 1
  • Fatema Tuz Zahra
    • 1
  • Michail S. Lionakis
    • 2
  • Nadezhda A. German
    • 3
    Email author
  • Constantinos M. Mikelis
    • 1
    Email author
  1. 1.Department of Biomedical Sciences, School of PharmacyTexas Tech University Health Sciences CenterAmarilloUSA
  2. 2.Laboratory of Clinical Immunology and Microbiology, Fungal Pathogenesis UnitNIAID, NIHBethesdaUSA
  3. 3.Department of Pharmaceutical Sciences, School of PharmacyTexas Tech University Health Sciences CenterAmarilloUSA

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