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Inflammation-induced lymphangiogenesis and lymphatic dysfunction

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Abstract

The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphatic contractile dysfunction occur in both vascular and nodal parts of the lymphatic system during inflammation, as well as other disease processes. This review provides a critical update on the role of the lymphatic system in disease process such as chronic inflammation and cancer and examines the changes in lymphatic functions the diseases cause and the influence these changes have on the progression of the diseases.

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Authors and Affiliations

  1. Inflammation Research Network, Snyder Institute for Chronic Diseases, Calgary, AB, T2N 4N1, Canada

    Shan Liao & Pierre-Yves von der Weid

  2. Department of Microbiology, Immunology and Infectious diseases, University of Calgary, Calgary, AB, T2N 4N1, Canada

    Shan Liao

  3. Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB, T2N 4N1, Canada

    Pierre-Yves von der Weid

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  1. Shan Liao
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  2. Pierre-Yves von der Weid
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Correspondence to Pierre-Yves von der Weid.

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Liao, S., von der Weid, PY. Inflammation-induced lymphangiogenesis and lymphatic dysfunction. Angiogenesis 17, 325–334 (2014). https://doi.org/10.1007/s10456-014-9416-7

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  • DOI: https://doi.org/10.1007/s10456-014-9416-7

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