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Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2

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Abstract

Prostate specific membrane antigen (PSMA) is a pro-angiogenic cell-surface protease that we previously demonstrated regulates blood vessel formation in a laminin and integrin β1-dependent manner. Here, we examine the principal mechanism of PSMA activation of integrin β1. We show that digesting laminin sequentially with recombinant matrix metalloprotease-2 (MMP-2) and PSMA generates small peptides that enhance endothelial cell adhesion and migration in vitro. We also provide evidence that these laminin peptides activate adhesion via integrin α6β1 and focal adhesion kinase. Using an in vivo Matrigel implant assay, we show that these MMP/PSMA-derived laminin peptides also increase angiogenesis in vivo. Together, our results reveal a novel mechanism of PSMA activation of angiogenesis by processing laminin downstream of MMP-2.

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Acknowledgments

The authors wish to acknowledge Amanda Williams for her technical support, Drs. Kent Gallaher Jon Lowrance, and Kent Clinger for their advice and support, Dylan Addis, Brian Burress, and Ryan Hudson for their preliminary research leading to this work, Joe Angevine for his technical assistance, and the Langford Yates Fellowship for partial financial support of this study. This work was supported, in part, by the Prostate Cancer Foundation and the Department of Defense Grant PC073976.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Biology, College of Arts and Sciences, Lipscomb University, Nashville, TN, 37204, USA

    Rebecca E. Conway, Kyle Joiner, Alex Patterson, David Bourgeois, Robert Rampp, Benjamin C. Hannah, Samantha McReynolds, John M. Elder & Hannah Gilfilen

  2. Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, 06030, USA

    Rebecca E. Conway & Linda H. Shapiro

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  1. Rebecca E. Conway
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  2. Kyle Joiner
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Corresponding author

Correspondence to Rebecca E. Conway.

Additional information

Kyle Joiner, Alex Patterson and David Bourgeois contributed equally to this work.

Robert Rampp, Benjamin C. Hannah and Samantha McReynolds contributed equally to this work.

John M. Elder and Hannah Gilfilen contributed equally to this work.

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Conway, R.E., Joiner, K., Patterson, A. et al. Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2. Angiogenesis 16, 847–860 (2013). https://doi.org/10.1007/s10456-013-9360-y

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  • DOI: https://doi.org/10.1007/s10456-013-9360-y

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