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The chick embryo chorioallantoic membrane as a model to study tumor metastasis

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Abstract

Tumor metastasis represents a major problem in the treatment of patients with different cancers. Specific phenotype and behavior of metastatic cells derive from specific molecular mechanisms involved in consecutive steps of the metastatic process. Several in vitro and in vivo experimental models have been utilized, but they cannot completely reproduce and characterize each step of the metastatic process. This review article is focused on the chick embryo chorioallantoic membrane as an in vivo model to study the metastatic process.

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Acknowledgments

Supported in part by MIUR (FIRB 2001), Rome, and Fondazione Cassa di Risparmio di Puglia, Bari, Italy.

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Authors and Affiliations

  1. Department of Histology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania

    Anca Maria Cimpean & Marius Raica

  2. Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico, 70124, Bari, Italy

    Domenico Ribatti

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  1. Anca Maria Cimpean
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  2. Domenico Ribatti
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Correspondence to Domenico Ribatti.

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Cimpean, A.M., Ribatti, D. & Raica, M. The chick embryo chorioallantoic membrane as a model to study tumor metastasis. Angiogenesis 11, 311–319 (2008). https://doi.org/10.1007/s10456-008-9117-1

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